Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 2000091..2000923 | Replicon | chromosome |
| Accession | NZ_CP049201 | ||
| Organism | Escherichia coli strain PapRG-04-4 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | A7ZVJ9 |
| Locus tag | G6Z99_RS09470 | Protein ID | WP_000854765.1 |
| Coordinates | 2000091..2000465 (-) | Length | 125 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | - |
| Locus tag | G6Z99_RS09475 | Protein ID | WP_164475635.1 |
| Coordinates | 2000555..2000923 (-) | Length | 123 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| G6Z99_RS09430 | 1995550..1995879 | + | 330 | WP_000450409.1 | DUF496 family protein | - |
| G6Z99_RS09435 | 1995980..1996162 | - | 183 | WP_001667686.1 | ethanolamine utilization - propanediol utilization family protein | - |
| G6Z99_RS09445 | 1996436..1997218 | - | 783 | WP_001317493.1 | IS21-like element IS100kyp family helper ATPase IstB | - |
| G6Z99_RS09450 | 1997215..1998237 | - | 1023 | WP_000255946.1 | IS21-like element IS100 family transposase | - |
| G6Z99_RS27075 | 1998575..1998964 | - | 390 | WP_206438893.1 | transposase | - |
| G6Z99_RS09460 | 1999762..1999875 | - | 114 | WP_001161660.1 | DUF957 domain-containing protein | - |
| G6Z99_RS09465 | 1999888..2000094 | - | 207 | WP_000976829.1 | hypothetical protein | - |
| G6Z99_RS09470 | 2000091..2000465 | - | 375 | WP_000854765.1 | TA system toxin CbtA family protein | Toxin |
| G6Z99_RS09475 | 2000555..2000923 | - | 369 | WP_164475635.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| G6Z99_RS09480 | 2001086..2001307 | - | 222 | WP_000692345.1 | DUF987 domain-containing protein | - |
| G6Z99_RS09485 | 2001370..2001846 | - | 477 | WP_001186774.1 | RadC family protein | - |
| G6Z99_RS09490 | 2001862..2002335 | - | 474 | WP_000855059.1 | antirestriction protein | - |
| G6Z99_RS09495 | 2002939..2004474 | + | 1536 | WP_000447022.1 | IS21-like element ISSso4 family transposase | - |
| G6Z99_RS09500 | 2004491..2005246 | + | 756 | WP_001282649.1 | IS21-like element ISSso4 family helper ATPase IstB | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | IScluster/Tn | - | - | 1996436..2005246 | 8810 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 125 a.a. Molecular weight: 13970.98 Da Isoelectric Point: 7.2909
>T150987 WP_000854765.1 NZ_CP049201:c2000465-2000091 [Escherichia coli]
MKTLPDTHVREVSCCPSPVTIWQTLLTRLLDQHYSLTLNDTPFVDERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGASSQLINSIDILRARRATGLMTRHNYRTVNNITLGKYPEAK
MKTLPDTHVREVSCCPSPVTIWQTLLTRLLDQHYSLTLNDTPFVDERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGASSQLINSIDILRARRATGLMTRHNYRTVNNITLGKYPEAK
Download Length: 375 bp
>T150987 NZ_CP065167:737225-737707 [Klebsiella pneumoniae]
ATGGAAATAAATGTCACTGCGCCTGCTTTACTGACAGAGGAGCATGTTCTTCATTCGTTCGATTGCGGGAATGCGGTACT
TGATGACTGGCTTCGCCGGCGTGCGTTGAAGAATCAGCATCTTAATGCTTCCCGGACATTCGTCATCTGTCCTGAAGGTA
CTGCGTGTGTAGTGGGTTATTATTCCCTTGCGACGGGCTCAGTTAGTCATGTCGACTTGAGTCGTAGTCTGCGACAGAAT
ATGCCCGATCCCGTACCGGTTGTTTTGCTGGGCCGCCTTGCAGTCGATGTATCCACTCAGGGCAATAACTTCGGGAAATG
GTTGCTGAATGATGCTGTGATGCGCGTATCGAATCTGGCGGATCAGGTCGGCATCAAGGCTATCATGGTGCATGCAATTG
ATGAGCGGGCTAAAGCGTTCTATGAATACTTTGGTTTTGTGCAGTCACCGGTTGCGGCTAACACGCTTTTCTACAAAATA
TAA
ATGGAAATAAATGTCACTGCGCCTGCTTTACTGACAGAGGAGCATGTTCTTCATTCGTTCGATTGCGGGAATGCGGTACT
TGATGACTGGCTTCGCCGGCGTGCGTTGAAGAATCAGCATCTTAATGCTTCCCGGACATTCGTCATCTGTCCTGAAGGTA
CTGCGTGTGTAGTGGGTTATTATTCCCTTGCGACGGGCTCAGTTAGTCATGTCGACTTGAGTCGTAGTCTGCGACAGAAT
ATGCCCGATCCCGTACCGGTTGTTTTGCTGGGCCGCCTTGCAGTCGATGTATCCACTCAGGGCAATAACTTCGGGAAATG
GTTGCTGAATGATGCTGTGATGCGCGTATCGAATCTGGCGGATCAGGTCGGCATCAAGGCTATCATGGTGCATGCAATTG
ATGAGCGGGCTAAAGCGTTCTATGAATACTTTGGTTTTGTGCAGTCACCGGTTGCGGCTAACACGCTTTTCTACAAAATA
TAA
Antitoxin
Download Length: 123 a.a. Molecular weight: 13591.41 Da Isoelectric Point: 6.9462
>AT150987 WP_164475635.1 NZ_CP049201:c2000923-2000555 [Escherichia coli]
VSDTLSGTTHPDDNNDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFRDADAYPLDQAFPLLMKQLKLMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK
VSDTLSGTTHPDDNNDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFRDADAYPLDQAFPLLMKQLKLMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK
Download Length: 369 bp
>AT150987 NZ_CP065167:736950-737234 [Klebsiella pneumoniae]
ATGCAAACTCCAGTCCGTAAATCCGTCCGTGACAAGCAAATCAATATCCGCGCCACGGATGAAGAACGTGCGGTGATTGA
TTACGCTGCGAGTCTGGTTAATAAAAACCGTACTGATTTCATCATTGAAAGGGCTGTGCATGAGGCCCAGAACATCATTC
TGGACCAGCGTGTGTTCGTTCTTGATGATGCCCGTTACCAGGCGTTCATCAGGCAGCTTGAAGCCCCTGTGCAGAATGTT
GAAGGTCGTCAGCGACTGATGGATGTAAAACCTGAATGGAAATAA
ATGCAAACTCCAGTCCGTAAATCCGTCCGTGACAAGCAAATCAATATCCGCGCCACGGATGAAGAACGTGCGGTGATTGA
TTACGCTGCGAGTCTGGTTAATAAAAACCGTACTGATTTCATCATTGAAAGGGCTGTGCATGAGGCCCAGAACATCATTC
TGGACCAGCGTGTGTTCGTTCTTGATGATGCCCGTTACCAGGCGTTCATCAGGCAGCTTGAAGCCCCTGTGCAGAATGTT
GAAGGTCGTCAGCGACTGATGGATGTAAAACCTGAATGGAAATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|