Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 779579..780377 | Replicon | chromosome |
| Accession | NZ_CP049201 | ||
| Organism | Escherichia coli strain PapRG-04-4 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | - |
| Locus tag | G6Z99_RS03765 | Protein ID | WP_057698567.1 |
| Coordinates | 779579..779956 (-) | Length | 126 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | - |
| Locus tag | G6Z99_RS03770 | Protein ID | WP_057698646.1 |
| Coordinates | 780003..780377 (-) | Length | 125 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| G6Z99_RS03735 | 775660..776196 | + | 537 | WP_000942790.1 | GspM family type II secretion system protein YghD | - |
| G6Z99_RS03740 | 776551..777498 | - | 948 | WP_057697651.1 | nucleotidyl transferase AbiEii/AbiGii toxin family protein | - |
| G6Z99_RS03745 | 777491..777886 | - | 396 | WP_000208385.1 | type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein | - |
| G6Z99_RS03750 | 777955..778800 | - | 846 | WP_158179441.1 | DUF4942 domain-containing protein | - |
| G6Z99_RS03755 | 778885..779082 | - | 198 | WP_000839249.1 | DUF957 domain-containing protein | - |
| G6Z99_RS03760 | 779094..779582 | - | 489 | WP_164475439.1 | hypothetical protein | - |
| G6Z99_RS03765 | 779579..779956 | - | 378 | WP_057698567.1 | TA system toxin CbtA family protein | Toxin |
| G6Z99_RS03770 | 780003..780377 | - | 375 | WP_057698646.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| G6Z99_RS03775 | 780453..780674 | - | 222 | WP_000692300.1 | DUF987 domain-containing protein | - |
| G6Z99_RS03780 | 780743..781219 | - | 477 | WP_001424026.1 | RadC family protein | - |
| G6Z99_RS03785 | 781235..781720 | - | 486 | WP_001563926.1 | antirestriction protein | - |
| G6Z99_RS03790 | 781812..782630 | - | 819 | WP_057697860.1 | DUF945 domain-containing protein | - |
| G6Z99_RS03795 | 782721..782975 | - | 255 | WP_057697859.1 | DUF905 family protein | - |
| G6Z99_RS03800 | 783017..783553 | - | 537 | WP_047628209.1 | DUF4234 domain-containing protein | - |
| G6Z99_RS03805 | 783616..784917 | - | 1302 | WP_164475440.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integrative and Conjugative Element | - | rfaE / gspC / gspD / gspE / gspF / gspG / gspH / gspI / gspJ / gspK / gspL / gspM / papC / papD / vipA/tssB / vipB/tssC / hcp/tssD / clpV/tssH | 671286..908004 | 236718 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 14106.07 Da Isoelectric Point: 8.2904
>T150984 WP_057698567.1 NZ_CP049201:c779956-779579 [Escherichia coli]
MKTLPDTHVREASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITQGKHPGAKQ
MKTLPDTHVREASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITQGKHPGAKQ
Download Length: 378 bp
>T150984 NZ_CP065167:337878-338246 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTATTAAGCGTACGGCACTGTTT
ATCACCCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCAGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCAGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGTTTGCGCGGATGA
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTATTAAGCGTACGGCACTGTTT
ATCACCCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCAGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCAGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGTTTGCGCGGATGA
Antitoxin
Download Length: 125 a.a. Molecular weight: 13750.44 Da Isoelectric Point: 5.4402
>AT150984 WP_057698646.1 NZ_CP049201:c780377-780003 [Escherichia coli]
VSDTLHVTNYPNDNNDRPWWGLPCTVTPCFGARLVQEGNQLHYLADRAGIRGQFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYARGLTCEADTLGSCGYVYMAVYSTLAPATTS
VSDTLHVTNYPNDNNDRPWWGLPCTVTPCFGARLVQEGNQLHYLADRAGIRGQFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYARGLTCEADTLGSCGYVYMAVYSTLAPATTS
Download Length: 375 bp
>AT150984 NZ_CP065167:337660-337881 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGGCGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGGCGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|