150976

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3566723..3567558 Replicon chromosome
Accession NZ_CP049198
Organism Escherichia coli strain E686

Toxin (Protein)


Gene name yeeV Uniprot ID A0A7U9IW37
Locus tag G6000_RS17060 Protein ID WP_023356554.1
Coordinates 3567181..3567558 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A4Q0BE16
Locus tag G6000_RS17055 Protein ID WP_032180374.1
Coordinates 3566723..3567091 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6000_RS17020 3562387..3563067 + 681 WP_001282921.1 WYL domain-containing protein -
G6000_RS17025 3563215..3563892 + 678 WP_001097302.1 hypothetical protein -
G6000_RS17030 3563898..3564131 + 234 WP_001278293.1 DUF905 family protein -
G6000_RS17035 3564221..3565039 + 819 WP_001175165.1 DUF945 domain-containing protein -
G6000_RS17040 3565305..3565784 + 480 WP_000706978.1 antirestriction protein -
G6000_RS17045 3565800..3566276 + 477 WP_001186774.1 RadC family protein -
G6000_RS17050 3566339..3566560 + 222 WP_023356553.1 DUF987 domain-containing protein -
G6000_RS17055 3566723..3567091 + 369 WP_032180374.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
G6000_RS17060 3567181..3567558 + 378 WP_023356554.1 TA system toxin CbtA family protein Toxin
G6000_RS17065 3567555..3567704 + 150 Protein_3337 hypothetical protein -
G6000_RS17070 3567783..3567977 + 195 WP_024181941.1 DUF957 domain-containing protein -
G6000_RS17075 3568062..3568904 + 843 WP_022645115.1 DUF4942 domain-containing protein -
G6000_RS17080 3569653..3571191 + 1539 WP_001187196.1 lysine decarboxylation/transport transcriptional activator CadC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3533221..3579003 45782


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14052.01 Da        Isoelectric Point: 7.8045

>T150976 WP_023356554.1 NZ_CP049198:3567181-3567558 [Escherichia coli]
MKTLPDTHVREVSCCPSPVTIWQTLLTRLLDQHYSLTLNDTPFADERVIEQHIEAGIALCDAVNFLVEKYALVRTDQPGF
SAGTSSQLINSIDILRARRATGLMTRSNYRTVNNITRGKHPEAKQ

Download         Length: 378 bp

>T150976 NZ_CP065162:2013674-2013776 [Klebsiella variicola]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13633.36 Da        Isoelectric Point: 6.2058

>AT150976 WP_032180374.1 NZ_CP049198:3566723-3567091 [Escherichia coli]
VSDTLSGTTHPDDNDDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFRDADAYPLDQAFPLLMKQLELMLTSG
ELNHRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT150976 NZ_CP065162:c2013782-2013638 [Klebsiella variicola]
ACCGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGT
TGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9IW37

Antitoxin

Source ID Structure
AlphaFold DB A0A4Q0BE16

References