Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 2984594..2985212 Replicon chromosome
Accession NZ_CP049197
Organism Escherichia coli strain E597

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag G6Z98_RS14170 Protein ID WP_001291435.1
Coordinates 2984994..2985212 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag G6Z98_RS14165 Protein ID WP_000344800.1
Coordinates 2984594..2984968 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6Z98_RS14155 2979683..2980876 + 1194 WP_001295833.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
G6Z98_RS14160 2980899..2984048 + 3150 WP_001132480.1 multidrug efflux RND transporter permease subunit -
G6Z98_RS14165 2984594..2984968 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
G6Z98_RS14170 2984994..2985212 + 219 WP_001291435.1 hemolysin expression modulator Hha Toxin
G6Z98_RS14175 2985384..2985935 + 552 WP_001522034.1 maltose O-acetyltransferase -
G6Z98_RS14180 2986051..2986521 + 471 WP_001490888.1 YlaC family protein -
G6Z98_RS14185 2986685..2988235 + 1551 WP_001577872.1 cyclic-guanylate-specific phosphodiesterase PdeB -
G6Z98_RS14190 2988277..2988630 - 354 WP_000878140.1 DUF1428 domain-containing protein -
G6Z98_RS14200 2989009..2989320 + 312 WP_000409911.1 MGMT family protein -
G6Z98_RS14205 2989351..2989923 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T150942 WP_001291435.1 NZ_CP049197:2984994-2985212 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T150942 NZ_CP065152:c1162798-1162691 [Escherichia coli O150:H6]
ATGACGCTCGCAGAACTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAATAAGCAGAAGTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT150942 WP_000344800.1 NZ_CP049197:2984594-2984968 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT150942 NZ_CP065152:1162846-1162912 [Escherichia coli O150:H6]
GGTCTAGGTTCAAGATTAGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References