Detailed information of TA system TA150939

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 2279081..2279925
• Replicon: chromosome
• Accession: NZ_CP049197
• Organism: Escherichia coli strain E597

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: B1LJY4
• Locus tag: G6Z98_RS11045
• Protein ID: WP_000854686.1
• Coordinates: 2279081..2279464 (-)
• Length: 128 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: A0A8E0J1S3
• Locus tag: G6Z98_RS11050
• Protein ID: WP_001285602.1
• Coordinates: 2279545..2279925 (-)
• Length: 127 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
G6Z98_RS11005	2274084..2274575	-	492	WP_001308552.1	DUF1097 domain-containing protein	-
G6Z98_RS11010	2274677..2275231	-	555	WP_001001921.1	molecular chaperone YcdY	-
G6Z98_RS11015	2275255..2275992	-	738	WP_000283664.1	zinc-binding phosphatase	-
G6Z98_RS11020	2276047..2276985	-	939	WP_001522839.1	glyoxylate/hydroxypyruvate reductase GhrA	-
G6Z98_RS11030	2277456..2278297	-	842	Protein_2161	DUF4942 domain-containing protein	-
G6Z98_RS11035	2278382..2278579	-	198	WP_000839253.1	DUF957 domain-containing protein	-
G6Z98_RS11040	2278596..2279084	-	489	WP_032180032.1	hypothetical protein	-
G6Z98_RS11045	2279081..2279464	-	384	WP_000854686.1	TA system toxin CbtA family protein	Toxin
G6Z98_RS11050	2279545..2279925	-	381	WP_001285602.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
G6Z98_RS11055	2279936..2280619	-	684	WP_000086768.1	hypothetical protein	-
G6Z98_RS11060	2280638..2280859	-	222	WP_000692298.1	DUF987 domain-containing protein	-
G6Z98_RS11065	2280922..2281398	-	477	WP_001186726.1	RadC family protein	-
G6Z98_RS11070	2281414..2281899	-	486	WP_000214307.1	antirestriction protein	-
G6Z98_RS11075	2281991..2282812	-	822	WP_001761104.1	DUF945 domain-containing protein	-
G6Z98_RS11080	2282913..2283121	-	209	Protein_2171	DUF905 family protein	-
G6Z98_RS11085	2283222..2283677	-	456	WP_000581506.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-113)

Antitoxin

• Antitoxin CbeA (18-117)

Sequences

Toxin

Protein

• Length: 128 a.a.
• Molecular weight: 14272.28 Da
• Isoelectric Point: 6.8614

>T150939 WP_000854686.1 NZ_CP049197:c2279464-2279081 [Escherichia coli]
MKTLPDTHVRAASRCPSPVEIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYVLVRTDQPGF
SAGAPSSQLINSIDILRARRATGLMTRDNYRMVNNITLGKHPEEAKQ

Nucleotide

• Length: 384 bp

>T150939 NZ_CP065152:c342094-341687 [Escherichia coli O150:H6]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGCATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCGCCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGACAGCGGAAAACGGCA
ACATTTATGGCTGGCAGCTGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATATTGTTACAACAAGAGACGC
AAAGATAA

Antitoxin

Protein

• Length: 127 a.a.
• Molecular weight: 13938.69 Da
• Isoelectric Point: 5.0823

>AT150939 WP_001285602.1 NZ_CP049197:c2279925-2279545 [Escherichia coli]
VSDTLPGTTLPDDNKDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSNADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCDADTLGSCGYVYLAVYPATETESNPPE

Nucleotide

• Length: 381 bp

>AT150939 NZ_CP065152:c342341-342075 [Escherichia coli O150:H6]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATTCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA