Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-RelB |
| Location | 1659119..1659645 | Replicon | chromosome |
| Accession | NZ_CP049197 | ||
| Organism | Escherichia coli strain E597 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | S1EXL1 |
| Locus tag | G6Z98_RS07925 | Protein ID | WP_000323025.1 |
| Coordinates | 1659358..1659645 (+) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | S1F6D3 |
| Locus tag | G6Z98_RS07920 | Protein ID | WP_000534858.1 |
| Coordinates | 1659119..1659358 (+) | Length | 80 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| G6Z98_RS07895 | 1654381..1654995 | + | 615 | WP_001265627.1 | hypothetical protein | - |
| G6Z98_RS07900 | 1654992..1656020 | + | 1029 | WP_001345551.1 | DUF4868 domain-containing protein | - |
| G6Z98_RS07905 | 1656504..1657817 | + | 1314 | WP_000589005.1 | ISNCY family transposase | - |
| G6Z98_RS07910 | 1658254..1658586 | - | 333 | WP_001301033.1 | protein FlxA | - |
| G6Z98_RS07915 | 1658789..1659094 | - | 306 | WP_001326990.1 | hypothetical protein | - |
| G6Z98_RS07920 | 1659119..1659358 | + | 240 | WP_000534858.1 | type II toxin-antitoxin system antitoxin RelB | Antitoxin |
| G6Z98_RS07925 | 1659358..1659645 | + | 288 | WP_000323025.1 | type II toxin-antitoxin system mRNA interferase RelE | Toxin |
| G6Z98_RS07930 | 1659717..1659872 | + | 156 | WP_000813254.1 | type I toxin-antitoxin system toxin HokD | - |
| G6Z98_RS07935 | 1660089..1660340 | + | 252 | WP_000980994.1 | hypothetical protein | - |
| G6Z98_RS07940 | 1660407..1660685 | + | 279 | WP_012304870.1 | hypothetical protein | - |
| G6Z98_RS07945 | 1660687..1661736 | + | 1050 | WP_001265199.1 | DUF968 domain-containing protein | - |
| G6Z98_RS07950 | 1661750..1662502 | + | 753 | WP_001047135.1 | antitermination protein | - |
| G6Z98_RS07955 | 1662780..1662869 | - | 90 | WP_120795389.1 | hypothetical protein | - |
| G6Z98_RS07960 | 1662924..1663136 | - | 213 | WP_000087756.1 | cold shock-like protein CspF | - |
| G6Z98_RS07965 | 1663437..1663652 | + | 216 | WP_000066484.1 | cold shock-like protein CspB | - |
| G6Z98_RS07970 | 1664406..1664621 | + | 216 | WP_000839590.1 | phage lysis protein EssD | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 1639569..1695252 | 55683 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11225.22 Da Isoelectric Point: 10.1967
>T150936 WP_000323025.1 NZ_CP049197:1659358-1659645 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
Download Length: 288 bp
>T150936 NZ_CP065152:67373-67693 [Escherichia coli O150:H6]
ATGCACATTTTATCTGTACCGACCACGGTGCCAGTTTCGTCACGCCTGTCGCCCGTACAGGTCTGGCAGCAACTGTTAAC
GTATCTGCTGGAGCAGCATTACGGCCTCACACTCAACGACACGCCATTCCACGACGACGCGGCTATCAAAGAACATATCG
AGGCGGGAATAACACTTGCTGATGCGGTGAATTTCCTGGTCGAAAAATACGAACTGGTTCGTATCGACCGAAAGGGGTTT
TCATGGCAGGATCAAACGCCATTCCTCAGCGCTACCGATATTCTCAGAGCAAGGCGAGCTACGGGGATTATGAGCACTTA
A
ATGCACATTTTATCTGTACCGACCACGGTGCCAGTTTCGTCACGCCTGTCGCCCGTACAGGTCTGGCAGCAACTGTTAAC
GTATCTGCTGGAGCAGCATTACGGCCTCACACTCAACGACACGCCATTCCACGACGACGCGGCTATCAAAGAACATATCG
AGGCGGGAATAACACTTGCTGATGCGGTGAATTTCCTGGTCGAAAAATACGAACTGGTTCGTATCGACCGAAAGGGGTTT
TCATGGCAGGATCAAACGCCATTCCTCAGCGCTACCGATATTCTCAGAGCAAGGCGAGCTACGGGGATTATGAGCACTTA
A
Antitoxin
Download Length: 80 a.a. Molecular weight: 9071.48 Da Isoelectric Point: 4.5230
>AT150936 WP_000534858.1 NZ_CP049197:1659119-1659358 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
Download Length: 240 bp
>AT150936 NZ_CP065152:67021-67341 [Escherichia coli O150:H6]
ATGAAAAATTCATGGGGACTGAGGCGCGACATGACGCCGTGCTTCGGTGCAAGGCTTGTGCAGGAAGGCCGTCGCCTGCA
TTTTCTGGCGGACCGTGCAGATATTAGCGGTGCGTTTAATGAGGAGGAGGCGCTACGTCTGGATCAAGCATTTCCGCTAG
TGATGAAACAGCTTGAATTGATGCTGACAACCGGTGAACTAAATCCACGCCATCAGCATTGCGTCACGTTGCATCATAAC
GGACTCACCTGCGAGGCGGATACTCTCGGCTCTCATGGCTACGTTTACATCGTTATTTATCCTCAGACATCGAGCCAGTA
A
ATGAAAAATTCATGGGGACTGAGGCGCGACATGACGCCGTGCTTCGGTGCAAGGCTTGTGCAGGAAGGCCGTCGCCTGCA
TTTTCTGGCGGACCGTGCAGATATTAGCGGTGCGTTTAATGAGGAGGAGGCGCTACGTCTGGATCAAGCATTTCCGCTAG
TGATGAAACAGCTTGAATTGATGCTGACAACCGGTGAACTAAATCCACGCCATCAGCATTGCGTCACGTTGCATCATAAC
GGACTCACCTGCGAGGCGGATACTCTCGGCTCTCATGGCTACGTTTACATCGTTATTTATCCTCAGACATCGAGCCAGTA
A
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|