Detailed information of TA system TA150920

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): chpSB/PRK09812-ChpS
• Location: 4019972..4020567
• Replicon: chromosome
• Accession: NZ_CP049196
• Organism: Escherichia coli strain E118

Toxin (Protein)

• Gene name: chpB
• Uniprot ID: V0SXT4
• Locus tag: G5T40_RS19265
• Protein ID: WP_000239581.1
• Coordinates: 4019972..4020322 (-)
• Length: 117 a.a.

Antitoxin (Protein)

• Gene name: chpS
• Uniprot ID: L4JJX7
• Locus tag: G5T40_RS19270
• Protein ID: WP_001223213.1
• Coordinates: 4020316..4020567 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
G5T40_RS19245	4015426..4016448	-	1023	WP_001361374.1	ABC transporter permease	-
G5T40_RS19250	4016462..4017964	-	1503	WP_001522399.1	sugar ABC transporter ATP-binding protein	-
G5T40_RS19255	4018097..4019053	-	957	WP_001522398.1	galactofuranose ABC transporter substrate-binding protein YtfQ	-
G5T40_RS19260	4019363..4019893	+	531	WP_000055075.1	inorganic diphosphatase	-
G5T40_RS19265	4019972..4020322	-	351	WP_000239581.1	endoribonuclease toxin ChpB	Toxin
G5T40_RS19270	4020316..4020567	-	252	WP_001223213.1	type II toxin-antitoxin system antitoxin ChpS	Antitoxin
G5T40_RS19275	4020779..4021120	-	342	WP_001219160.1	gamma-glutamylcyclotransferase	-
G5T40_RS19280	4021123..4024902	-	3780	WP_001522396.1	autotransporter assembly complex protein TamB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (8-114)

Antitoxin

• SpoVT-AbrB domain (6-49)

Sequences

Toxin

Protein

• Length: 117 a.a.
• Molecular weight: 12453.41 Da
• Isoelectric Point: 6.2206

>T150920 WP_000239581.1 NZ_CP049196:c4020322-4019972 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAAGEVVEEALLRLQAVVE

Nucleotide

• Length: 351 bp

>T150920 NZ_CP065147:c14981-14598 [Proteus mirabilis]
ATGATATGGGTTAGCGCACAGGAAGTTATCGCTTTCCATGATCGTATATTACAACGTTTCCCAGGTGTGGCCGGTATGTC
CGATCCTGGCAGAGCGGAAGCTCTTATTTACCGGGTGCAAAACCGTAAACATTATGAAGGCATTACAGATGTGTTTGAAC
TGGCAGCAACTTATTGGGTCGCTATCGCTCGAGGGCACATATTTAATGACGGTAATAAACGTACCGCATTTTTTGTGACC
ATGACATTTCTCTATCGTAATGGCATCAGGATCCGCGATACTGGCAATATGCTGGAAAACTTAACAGTAGAAGCAGCTAC
AGGTGAGAAAACCGTCGACCAGTTAGCAAAACATCTACAAAACTTGGTAGAGAAAACTAACTAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9331.64 Da
• Isoelectric Point: 4.6509

>AT150920 WP_001223213.1 NZ_CP049196:c4020567-4020316 [Escherichia coli]
MRITIKRWGNSSGMVIPNVVMKELNLRPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNATELSEQDVWGKSTPAGD
EIW

Nucleotide

• Length: 252 bp

>AT150920 NZ_CP065147:c15199-14978 [Proteus mirabilis]
ATGCGTACATATACCTCGACACAAGCCCGAGCCAATATTTCAGAAGTATTAGATATTGCGACCCACGGTGAACCTGTTGA
AATCACCCGCAGAGACGGTTGTTCAGCGGTTGTTATCAGTAAAACTGAATTTGAGTCATACCAGAATGCTAAGCTAGATG
CAGAGTTTGATATGATGATGCAACGTCATGGACATACCGTAGAGGCGCTGACAAATCGATGA

Structures

Toxin

• AlphaFold DB: V0SXT4

Antitoxin

• AlphaFold DB: L4JJX7