Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 3744108..3744595 Replicon chromosome
Accession NZ_CP049196
Organism Escherichia coli strain E118

Toxin (Protein)


Gene name ccdB Uniprot ID -
Locus tag G5T40_RS17920 Protein ID WP_001520461.1
Coordinates 3744108..3744359 (-) Length 84 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID A0A2T1MJK4
Locus tag G5T40_RS17925 Protein ID WP_001520458.1
Coordinates 3744362..3744595 (-) Length 78 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G5T40_RS17895 3739720..3741006 + 1287 WP_000800457.1 peptidylprolyl isomerase SurA -
G5T40_RS17900 3741006..3741995 + 990 WP_001520462.1 4-hydroxythreonine-4-phosphate dehydrogenase PdxA -
G5T40_RS17905 3741992..3742813 + 822 WP_001065381.1 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA -
G5T40_RS17910 3742816..3743193 + 378 WP_000610901.1 Co2+/Mg2+ efflux protein ApaG -
G5T40_RS17915 3743200..3744048 + 849 WP_000257196.1 bis(5'-nucleosyl)-tetraphosphatase (symmetrical) ApaH -
G5T40_RS17920 3744108..3744359 - 252 WP_001520461.1 CcdB family protein Toxin
G5T40_RS17925 3744362..3744595 - 234 WP_001520458.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
G5T40_RS17930 3744681..3745160 - 480 WP_000624375.1 type 3 dihydrofolate reductase -
G5T40_RS17935 3745352..3747214 - 1863 WP_000377113.1 glutathione-regulated potassium-efflux system protein KefC -
G5T40_RS17940 3747207..3747737 - 531 WP_021522993.1 glutathione-regulated potassium-efflux system oxidoreductase KefF -
G5T40_RS17945 3747845..3749176 - 1332 WP_001520455.1 MFS transporter -
G5T40_RS17950 3749235..3749522 - 288 WP_000203747.1 ferredoxin-like protein FixX -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(2-82)

Antitoxin

(8-77)


Sequences


Toxin        


Download         Length: 84 a.a.        Molecular weight: 9482.12 Da        Isoelectric Point: 10.4134

>T150917 WP_001520461.1 NZ_CP049196:c3744359-3744108 [Escherichia coli]
MQFTVYRSRGRNAAFPFVIDVTSDIIGEINRRIVIPLTPIERFSRIRPPERLNPILLLVDGKEYVLMTHETATVPVNALG
TKF

Download         Length: 252 bp

>T150917 NZ_CP065146:c2019757-2019233 [Proteus mirabilis]
ATGACAATACCAAATTGGCACGAAGAAGCGATCAGTAAAAAACATAATAGAAATGGATTTAATTGTGGCGATGCAGTACT
AAACCAATTTCTGTATCGCCATGCAAGACAAAATCATGAGAATGGTAGTGCGAAAACATATTTAGCTATCAATAATAGTA
ATAATATTATATTAGGTTATTACAGCTTATGTCCTGCTTCTATTGAGTTCGAAAGAACGCCCGAATTGATCAAACATGGC
TTAGCGCGTCATGATATCCCTGTTTTTAAACTTGCACGACTAGCTACGGATCTATCCGTTCAAGGAAAAGGTTTGGGTGG
GCAATTATTGCTTGCAGCAGGAAGGCGTTGTCTTTCCGTTGCTAGTGAATTGGGAGGCGTTGCTTTACTTATAGATGCTA
AAAATGAACGAGTCGCTAATTGGTATATTAGCTACGGGGCAATACCATTATTAGATACCCCTCTTTCTTTATTAATTTCC
TTTAAAACCATTTATACTGCACTTTCAATGGCAAATAAAATATAA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8560.61 Da        Isoelectric Point: 5.8062

>AT150917 WP_001520458.1 NZ_CP049196:c3744595-3744362 [Escherichia coli]
MTAKRTTQSVTVTVDRELVNRARDAGLNMSATLMVALNAELKKHAATRWREENAEAIAALNQLADETGCFSDEYRSF

Download         Length: 234 bp

>AT150917 NZ_CP065146:c2020032-2019754 [Proteus mirabilis]
ATGGCTCAAGCACTAGTAGAAAACAGTGAACGAGTGTCAATTCGTATCACTACAGAAGATAAATCACTGCTGGTTCGTGC
TGCTAGTTTGGAAAATACAAACTTAACAGAGTTTGTACTTCGTAATATTGTACCTGTAGCTCGGCAAGTTATTGAAAATA
ATGAGCGTTTAAAATTATCAGAAAAAGACACATTACGTGTTATGGAACTTTTAGATAATCCACCAAAGCCTAATGCTAAA
CTACTTGCAGCGGCTTTTGCTCTACCGGACAATGCATGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure
AlphaFold DB A0A2T1MJK4

References