Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | ccdAB/CcdA(antitoxin) |
Location | 3744108..3744595 | Replicon | chromosome |
Accession | NZ_CP049196 | ||
Organism | Escherichia coli strain E118 |
Toxin (Protein)
Gene name | ccdB | Uniprot ID | - |
Locus tag | G5T40_RS17920 | Protein ID | WP_001520461.1 |
Coordinates | 3744108..3744359 (-) | Length | 84 a.a. |
Antitoxin (Protein)
Gene name | ccdA | Uniprot ID | A0A2T1MJK4 |
Locus tag | G5T40_RS17925 | Protein ID | WP_001520458.1 |
Coordinates | 3744362..3744595 (-) | Length | 78 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
G5T40_RS17895 | 3739720..3741006 | + | 1287 | WP_000800457.1 | peptidylprolyl isomerase SurA | - |
G5T40_RS17900 | 3741006..3741995 | + | 990 | WP_001520462.1 | 4-hydroxythreonine-4-phosphate dehydrogenase PdxA | - |
G5T40_RS17905 | 3741992..3742813 | + | 822 | WP_001065381.1 | 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA | - |
G5T40_RS17910 | 3742816..3743193 | + | 378 | WP_000610901.1 | Co2+/Mg2+ efflux protein ApaG | - |
G5T40_RS17915 | 3743200..3744048 | + | 849 | WP_000257196.1 | bis(5'-nucleosyl)-tetraphosphatase (symmetrical) ApaH | - |
G5T40_RS17920 | 3744108..3744359 | - | 252 | WP_001520461.1 | CcdB family protein | Toxin |
G5T40_RS17925 | 3744362..3744595 | - | 234 | WP_001520458.1 | type II toxin-antitoxin system CcdA family antitoxin | Antitoxin |
G5T40_RS17930 | 3744681..3745160 | - | 480 | WP_000624375.1 | type 3 dihydrofolate reductase | - |
G5T40_RS17935 | 3745352..3747214 | - | 1863 | WP_000377113.1 | glutathione-regulated potassium-efflux system protein KefC | - |
G5T40_RS17940 | 3747207..3747737 | - | 531 | WP_021522993.1 | glutathione-regulated potassium-efflux system oxidoreductase KefF | - |
G5T40_RS17945 | 3747845..3749176 | - | 1332 | WP_001520455.1 | MFS transporter | - |
G5T40_RS17950 | 3749235..3749522 | - | 288 | WP_000203747.1 | ferredoxin-like protein FixX | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 84 a.a. Molecular weight: 9482.12 Da Isoelectric Point: 10.4134
>T150917 WP_001520461.1 NZ_CP049196:c3744359-3744108 [Escherichia coli]
MQFTVYRSRGRNAAFPFVIDVTSDIIGEINRRIVIPLTPIERFSRIRPPERLNPILLLVDGKEYVLMTHETATVPVNALG
TKF
MQFTVYRSRGRNAAFPFVIDVTSDIIGEINRRIVIPLTPIERFSRIRPPERLNPILLLVDGKEYVLMTHETATVPVNALG
TKF
Download Length: 252 bp
>T150917 NZ_CP065146:c2019757-2019233 [Proteus mirabilis]
ATGACAATACCAAATTGGCACGAAGAAGCGATCAGTAAAAAACATAATAGAAATGGATTTAATTGTGGCGATGCAGTACT
AAACCAATTTCTGTATCGCCATGCAAGACAAAATCATGAGAATGGTAGTGCGAAAACATATTTAGCTATCAATAATAGTA
ATAATATTATATTAGGTTATTACAGCTTATGTCCTGCTTCTATTGAGTTCGAAAGAACGCCCGAATTGATCAAACATGGC
TTAGCGCGTCATGATATCCCTGTTTTTAAACTTGCACGACTAGCTACGGATCTATCCGTTCAAGGAAAAGGTTTGGGTGG
GCAATTATTGCTTGCAGCAGGAAGGCGTTGTCTTTCCGTTGCTAGTGAATTGGGAGGCGTTGCTTTACTTATAGATGCTA
AAAATGAACGAGTCGCTAATTGGTATATTAGCTACGGGGCAATACCATTATTAGATACCCCTCTTTCTTTATTAATTTCC
TTTAAAACCATTTATACTGCACTTTCAATGGCAAATAAAATATAA
ATGACAATACCAAATTGGCACGAAGAAGCGATCAGTAAAAAACATAATAGAAATGGATTTAATTGTGGCGATGCAGTACT
AAACCAATTTCTGTATCGCCATGCAAGACAAAATCATGAGAATGGTAGTGCGAAAACATATTTAGCTATCAATAATAGTA
ATAATATTATATTAGGTTATTACAGCTTATGTCCTGCTTCTATTGAGTTCGAAAGAACGCCCGAATTGATCAAACATGGC
TTAGCGCGTCATGATATCCCTGTTTTTAAACTTGCACGACTAGCTACGGATCTATCCGTTCAAGGAAAAGGTTTGGGTGG
GCAATTATTGCTTGCAGCAGGAAGGCGTTGTCTTTCCGTTGCTAGTGAATTGGGAGGCGTTGCTTTACTTATAGATGCTA
AAAATGAACGAGTCGCTAATTGGTATATTAGCTACGGGGCAATACCATTATTAGATACCCCTCTTTCTTTATTAATTTCC
TTTAAAACCATTTATACTGCACTTTCAATGGCAAATAAAATATAA
Antitoxin
Download Length: 78 a.a. Molecular weight: 8560.61 Da Isoelectric Point: 5.8062
>AT150917 WP_001520458.1 NZ_CP049196:c3744595-3744362 [Escherichia coli]
MTAKRTTQSVTVTVDRELVNRARDAGLNMSATLMVALNAELKKHAATRWREENAEAIAALNQLADETGCFSDEYRSF
MTAKRTTQSVTVTVDRELVNRARDAGLNMSATLMVALNAELKKHAATRWREENAEAIAALNQLADETGCFSDEYRSF
Download Length: 234 bp
>AT150917 NZ_CP065146:c2020032-2019754 [Proteus mirabilis]
ATGGCTCAAGCACTAGTAGAAAACAGTGAACGAGTGTCAATTCGTATCACTACAGAAGATAAATCACTGCTGGTTCGTGC
TGCTAGTTTGGAAAATACAAACTTAACAGAGTTTGTACTTCGTAATATTGTACCTGTAGCTCGGCAAGTTATTGAAAATA
ATGAGCGTTTAAAATTATCAGAAAAAGACACATTACGTGTTATGGAACTTTTAGATAATCCACCAAAGCCTAATGCTAAA
CTACTTGCAGCGGCTTTTGCTCTACCGGACAATGCATGA
ATGGCTCAAGCACTAGTAGAAAACAGTGAACGAGTGTCAATTCGTATCACTACAGAAGATAAATCACTGCTGGTTCGTGC
TGCTAGTTTGGAAAATACAAACTTAACAGAGTTTGTACTTCGTAATATTGTACCTGTAGCTCGGCAAGTTATTGAAAATA
ATGAGCGTTTAAAATTATCAGAAAAAGACACATTACGTGTTATGGAACTTTTAGATAATCCACCAAAGCCTAATGCTAAA
CTACTTGCAGCGGCTTTTGCTCTACCGGACAATGCATGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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