Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4048062..4048682 Replicon chromosome
Accession NZ_CP049192
Organism Enterobacter hormaechei strain Y2152

Toxin (Protein)


Gene name Hha Uniprot ID A0A837FFM2
Locus tag G5577_RS18985 Protein ID WP_015571250.1
Coordinates 4048062..4048280 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID F5RUW7
Locus tag G5577_RS18990 Protein ID WP_006809850.1
Coordinates 4048308..4048682 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G5577_RS18955 4044074..4044334 + 261 WP_015571255.1 type B 50S ribosomal protein L31 -
G5577_RS18960 4044337..4044477 + 141 WP_003859006.1 type B 50S ribosomal protein L36 -
G5577_RS18965 4044474..4045184 - 711 WP_047654115.1 GNAT family N-acetyltransferase -
G5577_RS18970 4045286..4046746 + 1461 WP_047654114.1 PLP-dependent aminotransferase family protein -
G5577_RS18975 4046718..4047185 - 468 WP_022650495.1 hypothetical protein -
G5577_RS18980 4047302..4047853 - 552 WP_164474285.1 maltose O-acetyltransferase -
G5577_RS18985 4048062..4048280 - 219 WP_015571250.1 hemolysin expression modulator Hha Toxin
G5577_RS18990 4048308..4048682 - 375 WP_006809850.1 Hha toxicity modulator TomB Antitoxin
G5577_RS18995 4049192..4052338 - 3147 WP_022650497.1 multidrug efflux RND transporter permease subunit -
G5577_RS19000 4052361..4053554 - 1194 WP_058652691.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8583.95 Da        Isoelectric Point: 8.9008

>T150890 WP_015571250.1 NZ_CP049192:c4048280-4048062 [Enterobacter hormaechei]
MSDKPLTKVDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFVR

Download         Length: 219 bp

>T150890 NZ_CP065136:3522620-3523006 [Escherichia coli]
ATGGGTGTGTATAAGGCAAGACGATTCAGCCAAAGCACGAAAAAACTTGGTATTCACGATAAAGTTCTCATGGCTGCCGC
TGAAGAAGTGATGCAGGGCATATGGGAGGCTGATTTAGGTAGCGGTGTCATCAAAAAACGTTTACCCCTCCAACAAGGAA
AGAGTGGTGGAGCCAGAACAATTATCTTTTTTAAATCAGCAAATCATGTGTTTTTTTATGATGGTTGGTCCAAGAGTGGT
CTAAGCAGTAAAGGAACCAAAGAAATCGAAGATGATGAACTGGCGGCCTACAAAAAAATGGCAAATGCATTTCTGGCCTT
TAGCAATAAGCAAATAGAGGATTTGATCGAAACTGGCTTTTTGATTGAGGTGAAAAATGAGCGATAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14497.28 Da        Isoelectric Point: 4.8989

>AT150890 WP_006809850.1 NZ_CP049192:c4048682-4048308 [Enterobacter hormaechei]
MDEYSPKRHDIAQLKFLCESLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFTNVSRANPVSLSC

Download         Length: 375 bp

>AT150890 NZ_CP065136:3522996-3523325 [Escherichia coli]
ATGAGCGATAAATTACAAATGATGCTGGAAGATGCAAAGGAACTGAATGCACTGGGCCTGATGTCTGATAGTGAAGTTGA
TGCCATTGCCGTCATGGTCAAAGCTCGTGAAGTCAGCGCCCGTATAGCCAAAGTCAAATCAATGACGGGTGAAGAGATCA
AAGCCATCCGCACCCGATACGGCATGTCACAATCCGTGCTGGCACATACAATGGGAATGTCAAAAGAAAGTGTCTCGAAA
TGGGAACGTAATGAAATAAAACCGAGCGGCCCGGCATTACGTATTTTGAATACATTGGCAATAAAAGGGCCGGAAGTTTT
TGCAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A837FFM2

Antitoxin

Source ID Structure
AlphaFold DB A0A837FGN8

References