150887

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/COG3657-dnstrm_HI1420
Location 3187308..3187904 Replicon chromosome
Accession NZ_CP049192
Organism Enterobacter hormaechei strain Y2152

Toxin (Protein)


Gene name PumA Uniprot ID A0A837F9W8
Locus tag G5577_RS14975 Protein ID WP_023315213.1
Coordinates 3187602..3187904 (-) Length 101 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID A0A837FG03
Locus tag G5577_RS14970 Protein ID WP_022650216.1
Coordinates 3187308..3187595 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G5577_RS14965 3185680..3187311 + 1632 WP_137047909.1 Na/Pi cotransporter family protein -
G5577_RS14970 3187308..3187595 - 288 WP_022650216.1 putative addiction module antidote protein Antitoxin
G5577_RS14975 3187602..3187904 - 303 WP_023315213.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
G5577_RS14980 3188102..3188974 + 873 WP_022646725.1 23S rRNA pseudouridine(2604) synthase RluF -
G5577_RS14985 3188975..3189247 - 273 WP_003860346.1 DUF3811 domain-containing protein -
G5577_RS14990 3189298..3190242 - 945 WP_022650218.1 ketopantoate/pantoate/pantothenate transporter PanS -
G5577_RS14995 3190336..3191685 - 1350 WP_045337031.1 lysine-sensitive aspartokinase 3 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(3-93)

Antitoxin

Uncharacterized protein HI1420

(3-90)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11427.21 Da        Isoelectric Point: 10.1042

>T150887 WP_023315213.1 NZ_CP049192:c3187904-3187602 [Enterobacter hormaechei]
MKEIVQTESFRRWEQNLKDRRAKTIIASRLFRLANGLAGDIRPVGEGISELRIHFGPGYRVYFKDQGNCIIVLLCGGDKS
SQARDILMAKMLSNVSQWQE

Download         Length: 303 bp

>T150887 NZ_CP065136:2985050-2985157 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10087.57 Da        Isoelectric Point: 5.7807

>AT150887 WP_022650216.1 NZ_CP049192:c3187595-3187308 [Enterobacter hormaechei]
MHKLTPYDPANALVDDEEIAVFMADALETGDSAYIAKALGVIARAKGMSTISQQTGLSREQLYRSFSDKGNPTLKTTLAV
MKALGLGLTIKPSGD

Download         Length: 288 bp

>AT150887 NZ_CP065136:c2984997-2984936 [Escherichia coli]
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A837F9W8

Antitoxin

Source ID Structure
AlphaFold DB A0A837FG03

References