Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 1966568..1967225 Replicon chromosome
Accession NZ_CP049192
Organism Enterobacter hormaechei strain Y2152

Toxin (Protein)


Gene name cptA Uniprot ID A0A0A6GSQ9
Locus tag G5577_RS09200 Protein ID WP_022649305.1
Coordinates 1966568..1966978 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID G8LDB7
Locus tag G5577_RS09205 Protein ID WP_003863437.1
Coordinates 1966959..1967225 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G5577_RS09180 1962566..1964299 - 1734 WP_023314793.1 single-stranded-DNA-specific exonuclease RecJ -
G5577_RS09185 1964305..1965018 - 714 WP_003863443.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
G5577_RS09190 1965047..1965943 - 897 WP_003863442.1 site-specific tyrosine recombinase XerD -
G5577_RS09195 1966045..1966566 + 522 WP_059294460.1 flavodoxin FldB -
G5577_RS09200 1966568..1966978 - 411 WP_022649305.1 protein YgfX Toxin
G5577_RS09205 1966959..1967225 - 267 WP_003863437.1 FAD assembly factor SdhE Antitoxin
G5577_RS09210 1967520..1968500 + 981 WP_022649306.1 tRNA-modifying protein YgfZ -
G5577_RS09215 1968586..1969246 - 661 Protein_1808 hemolysin III family protein -
G5577_RS09220 1969513..1970244 + 732 WP_137048235.1 MurR/RpiR family transcriptional regulator -
G5577_RS09225 1970361..1971794 + 1434 WP_003863430.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16321.21 Da        Isoelectric Point: 11.4775

>T150885 WP_022649305.1 NZ_CP049192:c1966978-1966568 [Enterobacter hormaechei]
VVLWQSDLRVSWRSQWMSLLLHGLVAAMVLLVPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWEMIGTPWMLNTGMMLRLRRVEDNRRQHLWLAADSMDPAEWRDLRRLIVQQPTQE

Download         Length: 411 bp

>T150885 NZ_CP065136:2545958-2546245 [Escherichia coli]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10526.96 Da        Isoelectric Point: 4.8310

>AT150885 WP_003863437.1 NZ_CP049192:c1967225-1966959 [Enterobacter hormaechei]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
QERGPVAI

Download         Length: 267 bp

>AT150885 NZ_CP065136:2545719-2545958 [Escherichia coli]
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A6GSQ9

Antitoxin

Source ID Structure
AlphaFold DB A0A837F8P5

References