150874

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 518210..518949 Replicon chromosome
Accession NZ_CP049192
Organism Enterobacter hormaechei strain Y2152

Toxin (Protein)


Gene name tacT Uniprot ID A0A3L9PBP9
Locus tag G5577_RS02495 Protein ID WP_003857133.1
Coordinates 518210..518695 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A927HKN6
Locus tag G5577_RS02500 Protein ID WP_045336276.1
Coordinates 518683..518949 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G5577_RS02465 513701..514273 + 573 WP_045346197.1 NAD(P)H-dependent oxidoreductase -
G5577_RS02470 514276..515295 + 1020 WP_045346198.1 aldo/keto reductase -
G5577_RS02475 515334..515711 + 378 WP_023292403.1 DUF1330 domain-containing protein -
G5577_RS02480 515748..516353 + 606 WP_071957458.1 NAD(P)H-dependent oxidoreductase -
G5577_RS02485 516394..517089 + 696 WP_207621942.1 antibiotic biosynthesis monooxygenase -
G5577_RS02490 517105..517908 + 804 WP_045346200.1 carboxymuconolactone decarboxylase family protein -
G5577_RS02495 518210..518695 - 486 WP_003857133.1 GNAT family N-acetyltransferase Toxin
G5577_RS02500 518683..518949 - 267 WP_045336276.1 DUF1778 domain-containing protein Antitoxin
G5577_RS02505 519013..519942 - 930 WP_164474191.1 LysR family transcriptional regulator -
G5577_RS02510 520072..521460 + 1389 WP_164474190.1 MFS transporter -
G5577_RS02515 521482..522477 - 996 WP_032658432.1 DUF2891 domain-containing protein -
G5577_RS02520 522487..523473 - 987 WP_003857123.1 DUF979 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(58-151)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17540.23 Da        Isoelectric Point: 9.9658

>T150874 WP_003857133.1 NZ_CP049192:c518695-518210 [Enterobacter hormaechei]
VGRVTAPEPLSSVHQLAEFVSGEAVLDEWLKQRGLKNQALGAARTFVVCKTGTKQVAGFYSLATGSVNHTQATGNLRRNM
PDPIPVIILARLAVDVSLRGNGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKAFYIHHGFKASQTQERTLFLRLP
Q

Download         Length: 486 bp

>T150874 NZ_CP065136:220247-220354 [Escherichia coli]
ATGACGCTCGCAGAACTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CATGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10032.46 Da        Isoelectric Point: 4.4857

>AT150874 WP_045336276.1 NZ_CP049192:c518949-518683 [Enterobacter hormaechei]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIDMLDAPVADDPAIEKLL
ARKPQWGV

Download         Length: 267 bp

>AT150874 NZ_CP065136:c220198-220135 [Escherichia coli]
GTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3L9PBP9

Antitoxin

Source ID Structure

References