Detailed information of TA system TA150865

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA(toxin)
• Location: 4312883..4314666
• Replicon: chromosome
• Accession: NZ_CP049188
• Organism: Enterobacter hormaechei strain Y323

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: G5C52_RS20315
• Protein ID: WP_045331150.1
• Coordinates: 4313317..4314666 (-)
• Length: 450 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: A0A837FFV9
• Locus tag: G5C52_RS20310
• Protein ID: WP_003859317.1
• Coordinates: 4312883..4313320 (-)
• Length: 146 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
G5C52_RS20290	4307902..4308924	+	1023	WP_003859324.1	HTH-type transcriptional regulator GalS	-
G5C52_RS20295	4309220..4310218	+	999	WP_045337654.1	galactose/glucose ABC transporter substrate-binding protein MglB	-
G5C52_RS20300	4310298..4311818	+	1521	WP_003859320.1	galactose/methyl galactoside ABC transporter ATP-binding protein MglA	-
G5C52_RS20305	4311834..4312844	+	1011	WP_003859318.1	galactose/methyl galactoside ABC transporter permease MglC	-
G5C52_RS20310	4312883..4313320	-	438	WP_003859317.1	helix-turn-helix domain-containing protein	Antitoxin
G5C52_RS20315	4313317..4314666	-	1350	WP_045331150.1	type II toxin-antitoxin system HipA family toxin	Toxin
G5C52_RS20320	4314801..4315511	-	711	WP_003859314.1	outer membrane permeability protein SanA	-
G5C52_RS20325	4315639..4316523	-	885	WP_003859312.1	cytidine deaminase	-
G5C52_RS20330	4316652..4317347	-	696	WP_003859310.1	CidB/LrgB family autolysis modulator	-
G5C52_RS20335	4317344..4317739	-	396	WP_003859308.1	CidA/LrgA family protein	-
G5C52_RS20340	4317908..4318843	+	936	WP_003859306.1	tRNA dihydrouridine(16) synthase DusC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (166-406)

Antitoxin

• Cro/C1-type helix-turn-helix domain (75-128)

Sequences

Toxin

Protein

• Length: 450 a.a.
• Molecular weight: 51140.83 Da
• Isoelectric Point: 4.6112

>T150865 WP_045331150.1 NZ_CP049188:c4314666-4313317 [Enterobacter hormaechei]
METLTVQAYLNETWTDIALIKYPGSEKNDWNITQLDYLTEYAINFLDYDDFHAVSVNHPVSLFFDDHGQPGWLRFIDDII
PAGASRRYWINALDISELPVGQQNFLLLKFGTMSPVGNLRIKESVPEWNKFASTKTFTVADVIDRAADFLDYAQERGAAA
GGATGAGGEAPKLLLRCSETDAIWIDTWQNEPDNRDRYYLVKYPRGNRTEVDCNILRAEFHYYHELNAMGFSTIPVETMR
LEEGSHYPSLWLPRFDIVRNEQDQLVRLGMESVYSLLQKAPGTLLDHETTLRALINKITSSHMVQQQGYQFDIPGFVTEW
VRRDLLNIIFGNSDNHGRNTAFVKAENQIMLSPVYDFAPMKADPEGIPRTLKWSLSCESGGDYNFNTIAQTLAEWIPPAT
LLDALHETAVQLIDLPERLAARGVPEQIMEMPAMGFRYIPDKLSRWGLL

Nucleotide

• Length: 1350 bp

>T150865 NZ_CP065059:c1293522-1293262 [Streptococcus equi subsp. zooepidemicus]
ATGTACCGTATAGAGTATTCTAAAAAGGCTCAAAAGCAGATTAAGAAAGTAGATAAGCAAATTCAGAGGTTGCTATTTGC
TTGGATTGATAAGTATTTAGAGGGAACAGATAACCCACGCGCAAATGGCAAAGGTTTGACCGGAAATCATGCTAATGAGT
GGCGTTATCGTATTGGTGATTATCGGCTTATTTGTGATATTCAAGATGATAAGATGGTTATTTTAGCGCTTGAGTTTGGG
CATTGTAAAGATATTTACTAA

Antitoxin

Protein

• Length: 146 a.a.
• Molecular weight: 16185.64 Da
• Isoelectric Point: 10.5154

>AT150865 WP_003859317.1 NZ_CP049188:c4313320-4312883 [Enterobacter hormaechei]
MKTPNEAESELLQTLAQVRSVNKKRHHDEAEEPDKPSVVKRQRVTQGLTRISTLDRQAVLHAAIRDILLGKITQGEALKR
LRVEVLGLKQDEYAKLVSVSRKTLSDVENNRGNYSADVINKIFKPFGLQTGLVPVSKSLIASLFS

Nucleotide

• Length: 438 bp

>AT150865 NZ_CP065059:c1293745-1293524 [Streptococcus equi subsp. zooepidemicus]
ATGAGTACAGTTACTATCAGATTAAATCAAGAAGAAGAAATATTTTTCAAAAGTTACGCCCAACTCACAGGGCAAAGTTT
ATCAAGTCTATTTAAAAAAGCCCTTGAGCGGGATATTGAAGATGAGTATGATTTAAAAATCTATCATCAAGCCTATGCTG
AATATAAAGCAGACCCTGAGACAATTAGCCATGCTGATTTTAAGAAAGAGCTAGGCTTATAA

Structures

Antitoxin

• AlphaFold DB: A0A837FFV9