Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/COG3657-dnstrm_HI1420
Location 2386678..2387274 Replicon chromosome
Accession NZ_CP049188
Organism Enterobacter hormaechei strain Y323

Toxin (Protein)


Gene name PumA Uniprot ID A0A837F9W8
Locus tag G5C52_RS11310 Protein ID WP_023315213.1
Coordinates 2386678..2386980 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID A0A837FG03
Locus tag G5C52_RS11315 Protein ID WP_022650216.1
Coordinates 2386987..2387274 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G5C52_RS11285 2381855..2382522 - 668 Protein_2209 glucose-6-phosphate isomerase -
G5C52_RS11290 2382897..2384246 + 1350 WP_045337031.1 lysine-sensitive aspartokinase 3 -
G5C52_RS11295 2384340..2385284 + 945 WP_022650218.1 ketopantoate/pantoate/pantothenate transporter PanS -
G5C52_RS11300 2385335..2385607 + 273 WP_003860346.1 DUF3811 domain-containing protein -
G5C52_RS11305 2385608..2386480 - 873 WP_022646725.1 23S rRNA pseudouridine(2604) synthase RluF -
G5C52_RS11310 2386678..2386980 + 303 WP_023315213.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
G5C52_RS11315 2386987..2387274 + 288 WP_022650216.1 putative addiction module antidote protein Antitoxin
G5C52_RS11320 2387271..2388902 - 1632 WP_137047909.1 Na/Pi cotransporter family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(3-93)

Antitoxin

Uncharacterized protein HI1420

(3-90)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11427.21 Da        Isoelectric Point: 10.1042

>T150861 WP_023315213.1 NZ_CP049188:2386678-2386980 [Enterobacter hormaechei]
MKEIVQTESFRRWEQNLKDRRAKTIIASRLFRLANGLAGDIRPVGEGISELRIHFGPGYRVYFKDQGNCIIVLLCGGDKS
SQARDILMAKMLSNVSQWQE

Download         Length: 303 bp

>T150861 NZ_CP065053:c7427489-7427142 [Massilia sp. CCM 8941]
GTGGTAAAGCGAGCCAAGTTTGGGCGTGGCGATATCATCCTCGTCAATCTTGACCCGACCAAGGGCCATGAACGACAAGG
CATGCGGCCTGCGCTTGTGTTATCGACCAGCGTGTTCAATGCGCTCGGCCTCGCGCTGGTGGCGCCAATTGCCCAGGGAG
GCGACTTTGCACGGCATGCCGGCTTCGCTGCGCCCTTGACTGGATCGGGCACGACAATCCAGGGCGTGGTACTGGTCAAT
CAAGTGCGCATGCTGGACCTGGAGGCGCGCGCCGCCAGACGGGTGGAAACGGCGCCCGAGTTTGTTGTCGATGATGCGCT
CGCACGCCTGCGTGCAATTACCGACTGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10087.57 Da        Isoelectric Point: 5.7807

>AT150861 WP_022650216.1 NZ_CP049188:2386987-2387274 [Enterobacter hormaechei]
MHKLTPYDPANALVDDEEIAVFMADALETGDSAYIAKALGVIARAKGMSTISQQTGLSREQLYRSFSDKGNPTLKTTLAV
MKALGLGLTIKPSGD

Download         Length: 288 bp

>AT150861 NZ_CP065053:c7427734-7427483 [Massilia sp. CCM 8941]
ATGGAATTGTCGGTACAAAAATGGGGTAACAGCGCGGCAGTGCGACTGCCCACCGAGTTGCTTGGCATCCTGAAGGCGAC
GTTGGGCGACAAGCTGACCGTCAGCGTGCAAAACGAGGGTGTGCTGCTGAAAGTAAAGCGACCGGCGTATTCGCTGGCGG
ACCTGGTGGCCCAGTGCGACCCCTCGGCACCGGAGCCCGTGGATATGGCTGCGTGGAGCAATGTCACGCCAGTAGGGCGT
GAAGCGTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A837F9W8

Antitoxin

Source ID Structure
AlphaFold DB A0A837FG03

References