Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yafW-ykfI/CbtA-CbeA
Location 1681934..1682601 Replicon chromosome
Accession NZ_CP049188
Organism Enterobacter hormaechei strain Y323

Toxin (Protein)


Gene name ykfI Uniprot ID A0A1Z3MRP6
Locus tag G5C52_RS08085 Protein ID WP_001581456.1
Coordinates 1682272..1682601 (+) Length 110 a.a.

Antitoxin (Protein)


Gene name yafW Uniprot ID S1EWR7
Locus tag G5C52_RS08080 Protein ID WP_000070396.1
Coordinates 1681934..1682251 (+) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G5C52_RS08035 1677371..1678192 + 822 WP_000197389.1 DUF945 domain-containing protein -
G5C52_RS08040 1678409..1679110 + 702 WP_006812588.1 WYL domain-containing protein -
G5C52_RS08045 1679151..1679387 + 237 WP_001144031.1 hypothetical protein -
G5C52_RS08050 1679387..1679830 + 444 WP_000824223.1 hypothetical protein -
G5C52_RS08055 1679854..1680321 + 468 WP_001581459.1 hypothetical protein -
G5C52_RS08060 1680398..1680637 + 240 WP_000194654.1 DUF905 domain-containing protein -
G5C52_RS08065 1680735..1681193 + 459 WP_000211838.1 antirestriction protein -
G5C52_RS08070 1681209..1681685 + 477 WP_000811693.1 RadC family protein -
G5C52_RS08075 1681694..1681915 + 222 WP_000691994.1 DUF987 domain-containing protein -
G5C52_RS08080 1681934..1682251 + 318 WP_000070396.1 type IV toxin-antitoxin system antitoxin YafW Antitoxin
G5C52_RS08085 1682272..1682601 + 330 WP_001581456.1 toxin Toxin
G5C52_RS08090 1682951..1683808 - 858 WP_001581455.1 DeoR/GlpR family DNA-binding transcription regulator -
G5C52_RS08095 1683939..1684889 - 951 WP_001581454.1 D-ribose ABC transporter substrate-binding protein -
G5C52_RS08100 1684978..1686060 - 1083 WP_006809988.1 ABC transporter permease -
G5C52_RS08105 1686063..1687601 - 1539 WP_001581451.1 sugar ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-108)

Antitoxin

Antitoxin CbeA

(6-104)


Sequences

Toxin        


Download         Length: 110 a.a.        Molecular weight: 12456.52 Da        Isoelectric Point: 8.5011

>T150859 WP_001581456.1 NZ_CP049188:1682272-1682601 [Enterobacter hormaechei]
MKTLPATTQRAVKPCLSPVAVWQMLLTRLLEQHYGLTINDTPFCNEAVIKEHIDAGITLADAVNFLVEKYELVRIDRKGF
SWQEQTPYISVVDILRARRSTDLLKTNVK

Download         Length: 330 bp

>T150859 NZ_CP065053:c37000-36653 [Massilia sp. CCM 8941]
GTGGTAAAGCGAGCCAAGTTTGGGCGTGGCGATATCATCCTCGTCAATCTTGACCCGACCAAGGGCCATGAACGACAAGG
CATGCGGCCTGCGCTTGTGTTATCGACCAGCGTGTTCAATGCGCTCGGCCTCGCGCTGGTGGCGCCAATTGCCCAGGGAG
GCGACTTTGCACGGCATGCCGGCTTCGCTGCGCCCTTGACTGGATCGGGCACGACAATCCAGGGCGTGGTACTGGTCAAT
CAAGTGCGCATGCTGGACCTGGAGGCGCGCGCCGCCAGACGGGTGGAAACGGCGCCCGAGTTTGTTGTCGATGATGCGCT
CGCACGCCTGCGTGCAATTACCGACTGA

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11982.62 Da        Isoelectric Point: 7.0270

>AT150859 WP_000070396.1 NZ_CP049188:1681934-1682251 [Enterobacter hormaechei]
MSNPTRGLQREITLRLGARLVQEGNRLHYLADRASITGKFSDIECRKLDETFPHFIRQMESMLTTGELSPHHAHCVTLYH
NDLTCEADTLGSCGYVYIAIYPTQR

Download         Length: 318 bp

>AT150859 NZ_CP065053:c37245-36994 [Massilia sp. CCM 8941]
ATGGAATTGTCGGTACAAAAATGGGGTAACAGCGCGGCAGTGCGACTGCCCACCGAGTTGCTTGGCATCCTGAAGGCGAC
GTTGGGCGACAAGCTGACCGTCAGCGTGCAAAACGAGGGTGTGCTGCTGAAAGTAAAGCGACCGGCGTATTCGCTGGCGG
ACCTGGTGGCCCAGTGCGACCCCTCGGCACCGGAGCCCGTGGATATGGCTGCGTGGAGCAATGTCACGCCAGTAGGGCGT
GAAGCGTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1Z3MRP6

Antitoxin

Source ID Structure
AlphaFold DB S1EWR7

References