Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1526974..1527594 Replicon chromosome
Accession NZ_CP049188
Organism Enterobacter hormaechei strain Y323

Toxin (Protein)


Gene name Hha Uniprot ID A0A837FFM2
Locus tag G5C52_RS07310 Protein ID WP_015571250.1
Coordinates 1527376..1527594 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID F5RUW7
Locus tag G5C52_RS07305 Protein ID WP_006809850.1
Coordinates 1526974..1527348 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G5C52_RS07295 1522102..1523295 + 1194 WP_058652691.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
G5C52_RS07300 1523318..1526464 + 3147 WP_022650497.1 multidrug efflux RND transporter permease subunit -
G5C52_RS07305 1526974..1527348 + 375 WP_006809850.1 Hha toxicity modulator TomB Antitoxin
G5C52_RS07310 1527376..1527594 + 219 WP_015571250.1 hemolysin expression modulator Hha Toxin
G5C52_RS07315 1527803..1528354 + 552 WP_164474285.1 maltose O-acetyltransferase -
G5C52_RS07320 1528471..1528938 + 468 WP_022650495.1 hypothetical protein -
G5C52_RS07325 1528910..1530370 - 1461 WP_047654114.1 PLP-dependent aminotransferase family protein -
G5C52_RS07330 1530472..1531182 + 711 WP_047654115.1 GNAT family N-acetyltransferase -
G5C52_RS07335 1531179..1531319 - 141 WP_003859006.1 type B 50S ribosomal protein L36 -
G5C52_RS07340 1531322..1531582 - 261 WP_015571255.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8583.95 Da        Isoelectric Point: 8.9008

>T150858 WP_015571250.1 NZ_CP049188:1527376-1527594 [Enterobacter hormaechei]
MSDKPLTKVDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFVR

Download         Length: 219 bp

>T150858 NZ_CP065052:c24371-24051 [Acinetobacter baumannii]
ATGTTATTTATTGAAACCAGCATCTTTACCAAGCAAATTAAAGACCTTGTATCTGATGAGGAATATCGTCAACTTCAGCA
AGATCTTTTGGTACAGCCTGATAGAGGTGACCTAATCAAGAATGGCGGTGGTATTCGCAAAGTACGTTGTGCTCAAGGTA
ACAAAGGGAAAAGTGGTGGGATACGGGTGATTTATTATTGGGTCACCGAGGATGATCAGATCTTTTTCTTAGTGGCTTAT
CCAAAATCAGTAAAAGATAATTTAACAGATAAGGAAACCGCCATTCTGCACCAACTCGTGAAGGAGCAATTTCATGGATA
A

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14497.28 Da        Isoelectric Point: 4.8989

>AT150858 WP_006809850.1 NZ_CP049188:1526974-1527348 [Enterobacter hormaechei]
MDEYSPKRHDIAQLKFLCESLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFTNVSRANPVSLSC

Download         Length: 375 bp

>AT150858 NZ_CP065052:c24058-23786 [Acinetobacter baumannii]
ATGGATAACAACTTATTTGATGACTTGGTTGCTTCAATCAAAGAAGCTGGAGCTATCAAACGTAAAGAAGTTAAAGCAAG
CCGAGTTACAGAACTCGAATTGCCTGATATTAAAGAAGTACGTGAAAAAACTGGCTTGAGCCAAAATGAATTTGCTGCAC
GTCTACATATTAGCCCCCGTACCCTGCAAAATTGGGAACAGGGACGACGCTATCCAACTGGACCAGCAGCTACATTGATT
CGAATTTTAGATGCTCACCCAAGCCTTATTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A837FFM2

Antitoxin

Source ID Structure
AlphaFold DB A0A837FGN8

References