Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelB(antitoxin)
Location 1626403..1627015 Replicon chromosome
Accession NZ_CP049187
Organism Streptococcus pyogenes strain TSPY1687

Toxin (Protein)


Gene name parE Uniprot ID Q1JJZ2
Locus tag G6Z52_RS08075 Protein ID WP_002988077.1
Coordinates 1626680..1627015 (+) Length 112 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q5X9X9
Locus tag G6Z52_RS08070 Protein ID WP_002988079.1
Coordinates 1626403..1626690 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6Z52_RS08045 (G6Z52_08110) 1621594..1622577 - 984 WP_002988088.1 tagatose-bisphosphate aldolase -
G6Z52_RS08050 (G6Z52_08115) 1622581..1623510 - 930 WP_002988085.1 tagatose-6-phosphate kinase -
G6Z52_RS08055 (G6Z52_08120) 1623556..1624071 - 516 WP_002988082.1 galactose-6-phosphate isomerase subunit LacB -
G6Z52_RS08060 (G6Z52_08125) 1624106..1624534 - 429 WP_002982747.1 galactose-6-phosphate isomerase subunit LacA -
G6Z52_RS08065 (G6Z52_08130) 1624980..1625753 + 774 WP_002982738.1 DeoR/GlpR family DNA-binding transcription regulator -
G6Z52_RS08070 (G6Z52_08135) 1626403..1626690 + 288 WP_002988079.1 DNA-damage-inducible protein J Antitoxin
G6Z52_RS08075 (G6Z52_08140) 1626680..1627015 + 336 WP_002988077.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
G6Z52_RS09245 (G6Z52_08145) 1627113..1628147 + 1035 Protein_1529 site-specific integrase -
G6Z52_RS08095 (G6Z52_08150) 1628267..1628659 - 393 WP_002982716.1 30S ribosomal protein S9 -
G6Z52_RS08100 (G6Z52_08155) 1628680..1629126 - 447 WP_002982710.1 50S ribosomal protein L13 -
G6Z52_RS08105 (G6Z52_08160) 1629344..1629550 - 207 WP_002982695.1 helix-turn-helix transcriptional regulator -
G6Z52_RS08110 (G6Z52_08165) 1629547..1630053 - 507 WP_002988070.1 hypothetical protein -
G6Z52_RS08115 (G6Z52_08170) 1630189..1631049 - 861 WP_002982687.1 DegV family protein -
G6Z52_RS08120 (G6Z52_08175) 1631146..1631664 - 519 WP_002982682.1 NYN domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-105)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 13117.83 Da        Isoelectric Point: 5.2144

>T150856 WP_002988077.1 NZ_CP049187:1626680-1627015 [Streptococcus pyogenes]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQRKMEQIISDIEKLEVFPEVGFDADEKYGSKISHYHSTKGYTLSKD
YIVLYHIEGEENRVAIDYLLPTQSDYIKLFK

Download         Length: 336 bp

>T150856 NZ_CP065051:c3385485-3385096 [Acinetobacter baumannii]
TTGATCAACCATTCGAATTTTAAGCTGAAATATAGTCGTTTTTCGATTATATTTCAGTTTTTTATTGGCTTAAGCTTAGC
AGTTCTATTTTATCAATTAATGCCGTTACTATGGTGGTTAGTTGTAATCAGCTTACTATTTATCAGCTTTATTTTCTTTT
TAAAGCGTCCGCAGCTTGCACAAATTGCTTATTTAGATAAAAAACTATGGTCGCTTGCTTATCATTCACAGAACACCATT
TCTCGCGTCAAAATTTTAAAAATAATTGATTATCAGATTTTCATAGTGATCTATTTTGAAGGTCATAAAACACTAACTTC
TATCATTTGGTTTGATCAAATGTCATTAGCGGAGTGGAAGAAGCTTAAAACTTTAGAAAAACTCCATTAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10934.56 Da        Isoelectric Point: 5.2318

>AT150856 WP_002988079.1 NZ_CP049187:1626403-1626690 [Streptococcus pyogenes]
MTTVKKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEINKNIEDVRQ
GKFYTSEEVRAELGL

Download         Length: 288 bp

>AT150856 NZ_CP065051:c3385749-3385492 [Acinetobacter baumannii]
ATGTCTGAAGAAATGACCTTGGAAGAACGTAAAGTAATCTATCGCGCACGTCGTGGTTTAAAGGAAATTGATGTCTATTT
TGACCCTTATGTGAAAAATTATTATTTAAAGGCAGACCCGGCAGAAAAAGCGTTGTTTGCTGAGTTGGTAGAACAGGAAG
ATCCTGATTTACTTGATTGGTTTATGGAAGTATCAGAACCACCACGTACCGAATTACGTGACTTTATCTATAAATTAAAA
CACTATGTTCATGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A660A236

Antitoxin

Source ID Structure
AlphaFold DB A0A4U7GX94

References