Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | V | Classification (family/domain) | ghoTS/ghoT-GhoS |
Location | 3601324..3601821 | Replicon | chromosome |
Accession | NZ_CP049185 | ||
Organism | Shigella sonnei strain 19.0821.3486 |
Toxin (Protein)
Gene name | ghoT | Uniprot ID | L4JJG6 |
Locus tag | G6O60_RS18395 | Protein ID | WP_001173343.1 |
Coordinates | 3601648..3601821 (+) | Length | 58 a.a. |
Antitoxin (Protein)
Gene name | ghoS | Uniprot ID | L4JK92 |
Locus tag | G6O60_RS18390 | Protein ID | WP_000398619.1 |
Coordinates | 3601324..3601620 (+) | Length | 99 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
G6O60_RS18370 (3598055) | 3598055..3598774 | - | 720 | WP_000611285.1 | two-component system response regulator DcuR | - |
G6O60_RS18375 (3598771) | 3598771..3600402 | - | 1632 | WP_001216495.1 | sensor histidine kinase | - |
G6O60_RS18380 (3600583) | 3600583..3600813 | + | 231 | WP_000371698.1 | 4Fe-4S mono-cluster protein YjdI | - |
G6O60_RS18385 (3600825) | 3600825..3601097 | + | 273 | WP_000405647.1 | GNAT family N-acetyltransferase | - |
G6O60_RS18390 (3601324) | 3601324..3601620 | + | 297 | WP_000398619.1 | type V toxin-antitoxin system endoribonuclease antitoxin GhoS | Antitoxin |
G6O60_RS18395 (3601648) | 3601648..3601821 | + | 174 | WP_001173343.1 | type V toxin-antitoxin system toxin GhoT | Toxin |
G6O60_RS18400 (3601940) | 3601940..3603457 | - | 1518 | Protein_3583 | lysine--tRNA ligase | - |
G6O60_RS18405 (3603694) | 3603694..3605151 | - | 1458 | WP_000856831.1 | dipeptide/tripeptide permease DtpC | - |
G6O60_RS18410 (3605210) | 3605210..3605467 | - | 258 | Protein_3585 | lysine decarboxylase LdcC | - |
G6O60_RS18415 (3605513) | 3605513..3606668 | - | 1156 | Protein_3586 | IS3 family transposase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Prophage | - | htpB | 3591263..3633757 | 42494 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 58 a.a. Molecular weight: 6555.06 Da Isoelectric Point: 10.2288
>T150849 WP_001173343.1 NZ_CP049185:3601648-3601821 [Shigella sonnei]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF
Download Length: 174 bp
>T150849 NZ_CP065047:c3088282-3087704 [Mycobacterium kubicae]
GTGAAGCGGCTCGACCTCGTTGTGGGCCCGAACGGCGCCGGCAAGTCGACGTTCATCGCGTTCACACTGGCGCCGTTGTT
GCCACGCAGCGTCTTCGTCAACGCCGACGAGATCGCAAAGCAGCGTTGGCCCGACGATCCGGCTGCACACGCCTATGACG
CAGCGCGGATCGCTGCGAACACCCGCGCCAAGCTGATCGAGGCTGGTGTTTCGTTCATCGCCGAAACGGTCTTTTCCCAT
CCGTCGAAGCTGGAATTGATCGGCTCTGCCCACGATGCGGGTTATGTCATCGCCTTACACGTCATGCTGATACCCGAGGC
CCTTGCCGTTGAACGCGTGAAGCGGCGCGTCCGTCACGGTGGTCACGATGTGCCGGAAAGCAAGATCCGGGAACGGCACC
GCCGACTGTGGCGTTTGGTGGCCGACGCAGTCGAGAAGTGCGACACCGCAACGATTTACGACAATTCTCGTATCGAGGGT
CCCCGAATTGTCGCGCAACTGACCGCGGGCACGGTCATCGGTGCACCGACGTGGCCGGCGTGGGCGTCGACGGAACTGTC
CCGACGCTGGCCGGCCTAG
GTGAAGCGGCTCGACCTCGTTGTGGGCCCGAACGGCGCCGGCAAGTCGACGTTCATCGCGTTCACACTGGCGCCGTTGTT
GCCACGCAGCGTCTTCGTCAACGCCGACGAGATCGCAAAGCAGCGTTGGCCCGACGATCCGGCTGCACACGCCTATGACG
CAGCGCGGATCGCTGCGAACACCCGCGCCAAGCTGATCGAGGCTGGTGTTTCGTTCATCGCCGAAACGGTCTTTTCCCAT
CCGTCGAAGCTGGAATTGATCGGCTCTGCCCACGATGCGGGTTATGTCATCGCCTTACACGTCATGCTGATACCCGAGGC
CCTTGCCGTTGAACGCGTGAAGCGGCGCGTCCGTCACGGTGGTCACGATGTGCCGGAAAGCAAGATCCGGGAACGGCACC
GCCGACTGTGGCGTTTGGTGGCCGACGCAGTCGAGAAGTGCGACACCGCAACGATTTACGACAATTCTCGTATCGAGGGT
CCCCGAATTGTCGCGCAACTGACCGCGGGCACGGTCATCGGTGCACCGACGTGGCCGGCGTGGGCGTCGACGGAACTGTC
CCGACGCTGGCCGGCCTAG
Antitoxin
Download Length: 99 a.a. Molecular weight: 11467.97 Da Isoelectric Point: 4.1705
>AT150849 WP_000398619.1 NZ_CP049185:3601324-3601620 [Shigella sonnei]
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLNIMTVDDYFRQFYK
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLNIMTVDDYFRQFYK
Download Length: 297 bp
>AT150849 NZ_CP065047:c3088694-3088305 [Mycobacterium kubicae]
ATGGCTAACGTCGCGGACCGGGTCACCAGGGTTGCCGCTGACTTGGTGGACAGCGCCGCTGCCGAGGGTGCTCGCCAGAG
CCGGTCGGCCAAACAGCAACTCGACCATTGGGCTCGGGTGGGCCGGGCGGTGTCGAGCCATCAGACGGCCTCGCGTCGTC
GGGTGGAGGCTGCCTTGGCCGGTGATCTGGACACCAACCGTCTGTCTGACGATGAGGGGCTTGTCTTCAACGCTGAGATT
TCGGCCGCTCTCGAGGAGTCATTGGCCGCCGCCCACTACGGTGATCTGCTGCGGGCGCAGGGCATTACGACCGTGGCGCT
CAACGACGACGGGCAGATCGTCGAGTACCAGCCCGACGGCACTACCTCCGTGGTCGATGTAGACGGATGA
ATGGCTAACGTCGCGGACCGGGTCACCAGGGTTGCCGCTGACTTGGTGGACAGCGCCGCTGCCGAGGGTGCTCGCCAGAG
CCGGTCGGCCAAACAGCAACTCGACCATTGGGCTCGGGTGGGCCGGGCGGTGTCGAGCCATCAGACGGCCTCGCGTCGTC
GGGTGGAGGCTGCCTTGGCCGGTGATCTGGACACCAACCGTCTGTCTGACGATGAGGGGCTTGTCTTCAACGCTGAGATT
TCGGCCGCTCTCGAGGAGTCATTGGCCGCCGCCCACTACGGTGATCTGCTGCGGGCGCAGGGCATTACGACCGTGGCGCT
CAACGACGACGGGCAGATCGTCGAGTACCAGCCCGACGGCACTACCTCCGTGGTCGATGTAGACGGATGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A7U9QI41 |
Antitoxin
Source | ID | Structure |
---|---|---|
PDB | 2LLZ | |
AlphaFold DB | A0A7U9QBH6 |