Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 3601324..3601821 Replicon chromosome
Accession NZ_CP049185
Organism Shigella sonnei strain 19.0821.3486

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag G6O60_RS18395 Protein ID WP_001173343.1
Coordinates 3601648..3601821 (+) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID L4JK92
Locus tag G6O60_RS18390 Protein ID WP_000398619.1
Coordinates 3601324..3601620 (+) Length 99 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6O60_RS18370 (3598055) 3598055..3598774 - 720 WP_000611285.1 two-component system response regulator DcuR -
G6O60_RS18375 (3598771) 3598771..3600402 - 1632 WP_001216495.1 sensor histidine kinase -
G6O60_RS18380 (3600583) 3600583..3600813 + 231 WP_000371698.1 4Fe-4S mono-cluster protein YjdI -
G6O60_RS18385 (3600825) 3600825..3601097 + 273 WP_000405647.1 GNAT family N-acetyltransferase -
G6O60_RS18390 (3601324) 3601324..3601620 + 297 WP_000398619.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
G6O60_RS18395 (3601648) 3601648..3601821 + 174 WP_001173343.1 type V toxin-antitoxin system toxin GhoT Toxin
G6O60_RS18400 (3601940) 3601940..3603457 - 1518 Protein_3583 lysine--tRNA ligase -
G6O60_RS18405 (3603694) 3603694..3605151 - 1458 WP_000856831.1 dipeptide/tripeptide permease DtpC -
G6O60_RS18410 (3605210) 3605210..3605467 - 258 Protein_3585 lysine decarboxylase LdcC -
G6O60_RS18415 (3605513) 3605513..3606668 - 1156 Protein_3586 IS3 family transposase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - htpB 3591263..3633757 42494


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(4-57)

Antitoxin

(5-94)


Sequences


Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T150849 WP_001173343.1 NZ_CP049185:3601648-3601821 [Shigella sonnei]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

>T150849 NZ_CP065047:c3088282-3087704 [Mycobacterium kubicae]
GTGAAGCGGCTCGACCTCGTTGTGGGCCCGAACGGCGCCGGCAAGTCGACGTTCATCGCGTTCACACTGGCGCCGTTGTT
GCCACGCAGCGTCTTCGTCAACGCCGACGAGATCGCAAAGCAGCGTTGGCCCGACGATCCGGCTGCACACGCCTATGACG
CAGCGCGGATCGCTGCGAACACCCGCGCCAAGCTGATCGAGGCTGGTGTTTCGTTCATCGCCGAAACGGTCTTTTCCCAT
CCGTCGAAGCTGGAATTGATCGGCTCTGCCCACGATGCGGGTTATGTCATCGCCTTACACGTCATGCTGATACCCGAGGC
CCTTGCCGTTGAACGCGTGAAGCGGCGCGTCCGTCACGGTGGTCACGATGTGCCGGAAAGCAAGATCCGGGAACGGCACC
GCCGACTGTGGCGTTTGGTGGCCGACGCAGTCGAGAAGTGCGACACCGCAACGATTTACGACAATTCTCGTATCGAGGGT
CCCCGAATTGTCGCGCAACTGACCGCGGGCACGGTCATCGGTGCACCGACGTGGCCGGCGTGGGCGTCGACGGAACTGTC
CCGACGCTGGCCGGCCTAG

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11467.97 Da        Isoelectric Point: 4.1705

>AT150849 WP_000398619.1 NZ_CP049185:3601324-3601620 [Shigella sonnei]
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLNIMTVDDYFRQFYK

Download         Length: 297 bp

>AT150849 NZ_CP065047:c3088694-3088305 [Mycobacterium kubicae]
ATGGCTAACGTCGCGGACCGGGTCACCAGGGTTGCCGCTGACTTGGTGGACAGCGCCGCTGCCGAGGGTGCTCGCCAGAG
CCGGTCGGCCAAACAGCAACTCGACCATTGGGCTCGGGTGGGCCGGGCGGTGTCGAGCCATCAGACGGCCTCGCGTCGTC
GGGTGGAGGCTGCCTTGGCCGGTGATCTGGACACCAACCGTCTGTCTGACGATGAGGGGCTTGTCTTCAACGCTGAGATT
TCGGCCGCTCTCGAGGAGTCATTGGCCGCCGCCCACTACGGTGATCTGCTGCGGGCGCAGGGCATTACGACCGTGGCGCT
CAACGACGACGGGCAGATCGTCGAGTACCAGCCCGACGGCACTACCTCCGTGGTCGATGTAGACGGATGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A7U9QI41


Antitoxin

Source ID Structure
PDB 2LLZ
AlphaFold DB A0A7U9QBH6

References