Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 722355..722839 Replicon chromosome
Accession NZ_CP049185
Organism Shigella sonnei strain 19.0821.3486

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A377EAU1
Locus tag G6O60_RS03915 Protein ID WP_014334020.1
Coordinates 722355..722645 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID A0A376K4R9
Locus tag G6O60_RS03920 Protein ID WP_005142544.1
Coordinates 722645..722839 (-) Length 65 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6O60_RS03880 (717872) 717872..718501 - 630 WP_000211519.1 phage antirepressor Ant -
G6O60_RS03885 (718769) 718769..719035 - 267 Protein_765 antA/AntB antirepressor family protein -
G6O60_RS03890 (719452) 719452..719556 - 105 Protein_766 4Fe-4S binding protein -
G6O60_RS03895 (719567) 719567..720643 - 1077 Protein_767 molybdopterin-dependent oxidoreductase -
G6O60_RS03900 (720701) 720701..721398 + 698 WP_237158184.1 IS1-like element IS1A family transposase -
G6O60_RS03905 (721546) 721546..721911 - 366 WP_024174355.1 hypothetical protein -
G6O60_RS03910 (721923) 721923..722075 - 153 WP_000379558.1 DUF1391 family protein -
G6O60_RS03915 (722355) 722355..722645 - 291 WP_014334020.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
G6O60_RS03920 (722645) 722645..722839 - 195 WP_005142544.1 hypothetical protein Antitoxin
G6O60_RS03925 (722859) 722859..723344 - 486 WP_053002468.1 helix-turn-helix domain-containing protein -
G6O60_RS03930 (723471) 723471..723734 + 264 WP_001048456.1 helix-turn-helix transcriptional regulator -
G6O60_RS03935 (723731) 723731..724156 + 426 WP_000693826.1 toxin YdaT family protein -
G6O60_RS03940 (724228) 724228..725292 + 1065 WP_001262380.1 hypothetical protein -
G6O60_RS03945 (725299) 725299..726045 + 747 WP_000788740.1 ATP-binding protein -
G6O60_RS03950 (726067) 726067..726792 + 726 WP_000450631.1 DUF1627 domain-containing protein -
G6O60_RS03955 (726808) 726808..727230 + 423 WP_001151171.1 DUF977 family protein -
G6O60_RS03960 (727288) 727288..727644 + 357 WP_005140877.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - sodB / rhs/PAAR / rhs/PAAR / rhs/PAAR / vgrG/tssI 568041..899160 331119


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11062.93 Da        Isoelectric Point: 10.2013

>T150843 WP_014334020.1 NZ_CP049185:c722645-722355 [Shigella sonnei]
MLPVLWLPSARDDLRQIVAYIAKENPAAARRMKIRIETSVLPLTEHPYLYPPSERVLGLREIVTHPNYIILYRVTASSIE
VVNIVHSRRQYPGKNS

Download         Length: 291 bp

>T150843 NZ_CP065044:4316343-4316648 [Pectobacterium aroidearum]
ATGCAATTCATTGTTTATGAATATAAACGCGCCAGCCACTACAAAATGTTTGTCGATGTGCAAAGCGATATTGTCGACAC
ACCAAAGCGGCGCATGGTCATCCCGCTTATCGAAGCACATCATCTGTCTGAGAAAGTGAATAAAACATTGTTCCCGCTGA
TTCGCATCGATGGGGAAGATTATCGGCTGATGACCACAGAGCTGTCGAGTGTTCCTGTTGAGGTGATTGGTGAGGCTATC
ATGGATCTTGGAGACTATGCCGATGAGATCAAGGATGCTATTAATCTTATGTTTTGGGGGATTTGA

Antitoxin


Download         Length: 65 a.a.        Molecular weight: 7097.98 Da        Isoelectric Point: 4.1759

>AT150843 WP_005142544.1 NZ_CP049185:c722839-722645 [Shigella sonnei]
MSTVLSPMVSEFETVEQENSYNEWLRAKVAASLADPRPAIPHDEVMAEMEQIIAQIAAATHRGE

Download         Length: 195 bp

>AT150843 NZ_CP065044:4316122-4316340 [Pectobacterium aroidearum]
ATGAAACACCGCGTCAGCGTTACCGTGGACAAAGACAATTATCAGGTTCTGAGTGCTGCCGGAGTCAATATTTCCGGGCT
GGTGAATGACGCCATTGGCAAAGAAGCCCGCCGCATTAAGGCTGAGGAGTGGAAAAAGGAAAACCGCGAAGGGATGGAAG
AAGTCGCCCGATTTATCGCGCAGAATGGCTCCTTTGCGGATGAAAACAGGAACTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A377EAU1

Antitoxin

Source ID Structure
AlphaFold DB A0A376K4R9

References