Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | paaR-paaA-parE/- |
| Location | 3933902..3934386 | Replicon | chromosome |
| Accession | NZ_CP049179 | ||
| Organism | Shigella sonnei strain L4094 | ||
Toxin (Protein)
| Gene name | parE_1 | Uniprot ID | A0A377EAU1 |
| Locus tag | G6O64_RS19785 | Protein ID | WP_014334020.1 |
| Coordinates | 3934096..3934386 (+) | Length | 97 a.a. |
Antitoxin (Protein)
| Gene name | paaA | Uniprot ID | A0A376K4R9 |
| Locus tag | G6O64_RS19780 | Protein ID | WP_005142544.1 |
| Coordinates | 3933902..3934096 (+) | Length | 65 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| G6O64_RS19740 (3929097) | 3929097..3929453 | - | 357 | WP_005140877.1 | hypothetical protein | - |
| G6O64_RS19745 (3929511) | 3929511..3929933 | - | 423 | WP_001151171.1 | DUF977 family protein | - |
| G6O64_RS19750 (3929949) | 3929949..3930674 | - | 726 | WP_000450631.1 | DUF1627 domain-containing protein | - |
| G6O64_RS19755 (3930696) | 3930696..3931442 | - | 747 | WP_000788740.1 | ATP-binding protein | - |
| G6O64_RS19760 (3931449) | 3931449..3932513 | - | 1065 | WP_001262380.1 | hypothetical protein | - |
| G6O64_RS19765 (3932585) | 3932585..3933010 | - | 426 | WP_000693826.1 | toxin YdaT family protein | - |
| G6O64_RS19770 (3933007) | 3933007..3933270 | - | 264 | WP_001048456.1 | helix-turn-helix transcriptional regulator | - |
| G6O64_RS19775 (3933397) | 3933397..3933882 | + | 486 | WP_053002468.1 | helix-turn-helix domain-containing protein | - |
| G6O64_RS19780 (3933902) | 3933902..3934096 | + | 195 | WP_005142544.1 | hypothetical protein | Antitoxin |
| G6O64_RS19785 (3934096) | 3934096..3934386 | + | 291 | WP_014334020.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| G6O64_RS19790 (3934666) | 3934666..3934818 | + | 153 | WP_000379558.1 | DUF1391 family protein | - |
| G6O64_RS19795 (3934830) | 3934830..3935195 | + | 366 | WP_024174355.1 | hypothetical protein | - |
| G6O64_RS19805 (3936098) | 3936098..3937174 | + | 1077 | Protein_3857 | molybdopterin dinucleotide binding domain-containing protein | - |
| G6O64_RS19810 (3937185) | 3937185..3937802 | + | 618 | WP_000213029.1 | dimethylsulfoxide reductase subunit B | - |
| G6O64_RS19815 (3937804) | 3937804..3938658 | + | 855 | WP_000526502.1 | dimethyl sulfoxide reductase anchor subunit family protein | - |
| G6O64_RS19820 (3938701) | 3938701..3939315 | + | 615 | WP_000148710.1 | Tat proofreading chaperone DmsD | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 3925066..3948953 | 23887 | |
| - | flank | IS/Tn | - | - | 3935343..3935846 | 503 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 97 a.a. Molecular weight: 11062.93 Da Isoelectric Point: 10.2013
>T150822 WP_014334020.1 NZ_CP049179:3934096-3934386 [Shigella sonnei]
MLPVLWLPSARDDLRQIVAYIAKENPAAARRMKIRIETSVLPLTEHPYLYPPSERVLGLREIVTHPNYIILYRVTASSIE
VVNIVHSRRQYPGKNS
MLPVLWLPSARDDLRQIVAYIAKENPAAARRMKIRIETSVLPLTEHPYLYPPSERVLGLREIVTHPNYIILYRVTASSIE
VVNIVHSRRQYPGKNS
Download Length: 291 bp
>T150822 NZ_CP065039:1797416-1797835 [Proteus mirabilis]
GTGAAAAAAGTCTATATGCTTGATACAAACATTTGTTCTTTTATCATGCGAGAGCAACCTATTTCTTTGCTCGAAAAACT
TCAGAAATGTGTAATGAACCACGATACTATTGTCATATCAGCGATTACTTATTCAGAGATGCGCTTTGGAGCAATAGGAA
AAAAAGCATCACCTAAACACAATCGTTTGGTTGATGCTTTCTGTGAACGCGTTGACGCGATTTTGGCATGGGATAAAGCG
GCGGTAGACGCAACTACCGTGATAAAAAAATGCTTATCTGATGTGGGATTGCCCATAGGAAATAATGATAGCGCGATTGC
TGGTCATGCTGTCGCGGTTAATGCAATATTGGTAACAAATAATACCCGTGAATTTTCACGAGTTGAAGGACTAAAAATAG
AGGACTGGACTCATGTTTGA
GTGAAAAAAGTCTATATGCTTGATACAAACATTTGTTCTTTTATCATGCGAGAGCAACCTATTTCTTTGCTCGAAAAACT
TCAGAAATGTGTAATGAACCACGATACTATTGTCATATCAGCGATTACTTATTCAGAGATGCGCTTTGGAGCAATAGGAA
AAAAAGCATCACCTAAACACAATCGTTTGGTTGATGCTTTCTGTGAACGCGTTGACGCGATTTTGGCATGGGATAAAGCG
GCGGTAGACGCAACTACCGTGATAAAAAAATGCTTATCTGATGTGGGATTGCCCATAGGAAATAATGATAGCGCGATTGC
TGGTCATGCTGTCGCGGTTAATGCAATATTGGTAACAAATAATACCCGTGAATTTTCACGAGTTGAAGGACTAAAAATAG
AGGACTGGACTCATGTTTGA
Antitoxin
Download Length: 65 a.a. Molecular weight: 7097.98 Da Isoelectric Point: 4.1759
>AT150822 WP_005142544.1 NZ_CP049179:3933902-3934096 [Shigella sonnei]
MSTVLSPMVSEFETVEQENSYNEWLRAKVAASLADPRPAIPHDEVMAEMEQIIAQIAAATHRGE
MSTVLSPMVSEFETVEQENSYNEWLRAKVAASLADPRPAIPHDEVMAEMEQIIAQIAAATHRGE
Download Length: 195 bp
>AT150822 NZ_CP065039:1797186-1797419 [Proteus mirabilis]
ATGAGAACGAGAACTGTAGCTGTATTTAAAAACGGAAGTAACCGAGCCATTCGCTTACCTAAAGATTTCGATTTTGATGG
TGTCAATGAACTCGAGATAAGCCGAGATGGGGATTGTATTATTTTACGCCCTGTAAAACCTAACTGGATTTCATTACAAA
ACGAAGAAAAAGCCGACAGTGATTTCTTGCTTGAACGCGATGATGTTATTGAAGAAGGACGAGTTATTCTGTGA
ATGAGAACGAGAACTGTAGCTGTATTTAAAAACGGAAGTAACCGAGCCATTCGCTTACCTAAAGATTTCGATTTTGATGG
TGTCAATGAACTCGAGATAAGCCGAGATGGGGATTGTATTATTTTACGCCCTGTAAAACCTAACTGGATTTCATTACAAA
ACGAAGAAAAAGCCGACAGTGATTTCTTGCTTGAACGCGATGATGTTATTGAAGAAGGACGAGTTATTCTGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A377EAU1 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A376K4R9 |