Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 3933902..3934386 Replicon chromosome
Accession NZ_CP049179
Organism Shigella sonnei strain L4094

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A377EAU1
Locus tag G6O64_RS19785 Protein ID WP_014334020.1
Coordinates 3934096..3934386 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID A0A376K4R9
Locus tag G6O64_RS19780 Protein ID WP_005142544.1
Coordinates 3933902..3934096 (+) Length 65 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6O64_RS19740 (3929097) 3929097..3929453 - 357 WP_005140877.1 hypothetical protein -
G6O64_RS19745 (3929511) 3929511..3929933 - 423 WP_001151171.1 DUF977 family protein -
G6O64_RS19750 (3929949) 3929949..3930674 - 726 WP_000450631.1 DUF1627 domain-containing protein -
G6O64_RS19755 (3930696) 3930696..3931442 - 747 WP_000788740.1 ATP-binding protein -
G6O64_RS19760 (3931449) 3931449..3932513 - 1065 WP_001262380.1 hypothetical protein -
G6O64_RS19765 (3932585) 3932585..3933010 - 426 WP_000693826.1 toxin YdaT family protein -
G6O64_RS19770 (3933007) 3933007..3933270 - 264 WP_001048456.1 helix-turn-helix transcriptional regulator -
G6O64_RS19775 (3933397) 3933397..3933882 + 486 WP_053002468.1 helix-turn-helix domain-containing protein -
G6O64_RS19780 (3933902) 3933902..3934096 + 195 WP_005142544.1 hypothetical protein Antitoxin
G6O64_RS19785 (3934096) 3934096..3934386 + 291 WP_014334020.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
G6O64_RS19790 (3934666) 3934666..3934818 + 153 WP_000379558.1 DUF1391 family protein -
G6O64_RS19795 (3934830) 3934830..3935195 + 366 WP_024174355.1 hypothetical protein -
G6O64_RS19805 (3936098) 3936098..3937174 + 1077 Protein_3857 molybdopterin dinucleotide binding domain-containing protein -
G6O64_RS19810 (3937185) 3937185..3937802 + 618 WP_000213029.1 dimethylsulfoxide reductase subunit B -
G6O64_RS19815 (3937804) 3937804..3938658 + 855 WP_000526502.1 dimethyl sulfoxide reductase anchor subunit family protein -
G6O64_RS19820 (3938701) 3938701..3939315 + 615 WP_000148710.1 Tat proofreading chaperone DmsD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 3925066..3948953 23887
- flank IS/Tn - - 3935343..3935846 503


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11062.93 Da        Isoelectric Point: 10.2013

>T150822 WP_014334020.1 NZ_CP049179:3934096-3934386 [Shigella sonnei]
MLPVLWLPSARDDLRQIVAYIAKENPAAARRMKIRIETSVLPLTEHPYLYPPSERVLGLREIVTHPNYIILYRVTASSIE
VVNIVHSRRQYPGKNS

Download         Length: 291 bp

>T150822 NZ_CP065039:1797416-1797835 [Proteus mirabilis]
GTGAAAAAAGTCTATATGCTTGATACAAACATTTGTTCTTTTATCATGCGAGAGCAACCTATTTCTTTGCTCGAAAAACT
TCAGAAATGTGTAATGAACCACGATACTATTGTCATATCAGCGATTACTTATTCAGAGATGCGCTTTGGAGCAATAGGAA
AAAAAGCATCACCTAAACACAATCGTTTGGTTGATGCTTTCTGTGAACGCGTTGACGCGATTTTGGCATGGGATAAAGCG
GCGGTAGACGCAACTACCGTGATAAAAAAATGCTTATCTGATGTGGGATTGCCCATAGGAAATAATGATAGCGCGATTGC
TGGTCATGCTGTCGCGGTTAATGCAATATTGGTAACAAATAATACCCGTGAATTTTCACGAGTTGAAGGACTAAAAATAG
AGGACTGGACTCATGTTTGA

Antitoxin


Download         Length: 65 a.a.        Molecular weight: 7097.98 Da        Isoelectric Point: 4.1759

>AT150822 WP_005142544.1 NZ_CP049179:3933902-3934096 [Shigella sonnei]
MSTVLSPMVSEFETVEQENSYNEWLRAKVAASLADPRPAIPHDEVMAEMEQIIAQIAAATHRGE

Download         Length: 195 bp

>AT150822 NZ_CP065039:1797186-1797419 [Proteus mirabilis]
ATGAGAACGAGAACTGTAGCTGTATTTAAAAACGGAAGTAACCGAGCCATTCGCTTACCTAAAGATTTCGATTTTGATGG
TGTCAATGAACTCGAGATAAGCCGAGATGGGGATTGTATTATTTTACGCCCTGTAAAACCTAACTGGATTTCATTACAAA
ACGAAGAAAAAGCCGACAGTGATTTCTTGCTTGAACGCGATGATGTTATTGAAGAAGGACGAGTTATTCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A377EAU1

Antitoxin

Source ID Structure
AlphaFold DB A0A376K4R9

References