150813

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 237495..238113 Replicon chromosome
Accession NZ_CP049179
Organism Shigella sonnei strain L4094

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag G6O64_RS01120 Protein ID WP_001291435.1
Coordinates 237895..238113 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A0H8V4S8
Locus tag G6O64_RS01115 Protein ID WP_000344804.1
Coordinates 237495..237869 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6O64_RS01105 (232584) 232584..233777 + 1194 WP_011310152.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
G6O64_RS01110 (233800) 233800..236949 + 3150 WP_001132464.1 efflux RND transporter permease AcrB -
G6O64_RS01115 (237495) 237495..237869 + 375 WP_000344804.1 Hha toxicity modulator TomB Antitoxin
G6O64_RS01120 (237895) 237895..238113 + 219 WP_001291435.1 HHA domain-containing protein Toxin
G6O64_RS01125 (238284) 238284..238835 + 552 WP_000102564.1 maltose O-acetyltransferase -
G6O64_RS01130 (238951) 238951..239421 + 471 WP_000136192.1 YlaC family protein -
G6O64_RS01135 (239585) 239585..241133 + 1549 Protein_221 cyclic-guanylate-specific phosphodiesterase PdeB -
G6O64_RS01140 (241175) 241175..241528 - 354 WP_000878140.1 DUF1428 domain-containing protein -
G6O64_RS01150 (241907) 241907..242218 + 312 WP_000409911.1 MGMT family protein -
G6O64_RS01155 (242249) 242249..242821 - 573 WP_000779812.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T150813 WP_001291435.1 NZ_CP049179:237895-238113 [Shigella sonnei]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T150813 NZ_CP065037:1437376-1437642 [Leifsonia sp. ZF2019]
ATGACGTACGAGGTGATCTTCGCCTCGACCGCTGTCCGGGATCTCGAGCGCATCCCGCCGAGGATCGTGCCAGCCGTCAT
CGAGTTCGCCTATGGCGATCTGGCGCGCAACCCTCGACGTGTCGGCAAGGCGCTGGAGCGGGAGCTCTCGGGCCTTTTCA
GTGCGCGGCGCGGTCCGTACCGGATTCTGTACGAGATCCAGGATGAAGAAGTCCGCGTCCTCGTCGTGCGGGTGGATCAC
CGCGCGGACGCGTATCGCCCCCGCTGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14615.43 Da        Isoelectric Point: 4.6232

>AT150813 WP_000344804.1 NZ_CP049179:237495-237869 [Shigella sonnei]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIETFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT150813 NZ_CP065037:1437101-1437379 [Leifsonia sp. ZF2019]
ATGCAGACTCTGCCGATCTCCGCCGTGAAGGCCCGCCTGAGTGAGCTGGTCGACTCCGCGTCGCACACTCGTGAAGAGGT
GGCAATCACGGTAAACGGGTCACCTGCCGCGATGCTGATCGGAATCGACGAATGGGAGGAGTTGCAGGAGCGTCTCCACT
GGCTCTCCACCGGTGACGACCTCGTTGCCCGGCTCGCCGAGGCGCGTCGAGAAGTCGAATCAGGCGGCGGACTCGGCGAA
GACGAGATCCGGGCGCGATTCGGCGTTCCGCGCCGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H8V4S8

References