Detailed information of TA system TA150808

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PsyrTA/-
• Location: 4348951..4350290
• Replicon: chromosome
• Accession: NZ_CP049177
• Organism: Shigella sonnei strain 1205.3131

Toxin (Protein)

• Gene name: PsyrT
• Uniprot ID: -
• Locus tag: G6O63_RS22155
• Protein ID: WP_001119379.1
• Coordinates: 4350153..4350290 (-)
• Length: 46 a.a.

Antitoxin (Protein)

• Gene name: PsyrA
• Uniprot ID: A0A656BP16
• Locus tag: G6O63_RS22150
• Protein ID: WP_001053680.1
• Coordinates: 4348951..4350153 (-)
• Length: 401 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
G6O63_RS22130 (4344558)	4344558..4346744	-	2187	WP_001283723.1	1,4-alpha-glucan branching enzyme	-
G6O63_RS22135 (4346902)	4346902..4346943	-	42	Protein_4321	hypothetical protein	-
G6O63_RS22140 (4347017)	4347017..4348120	-	1104	WP_000799956.1	aspartate-semialdehyde dehydrogenase	-
G6O63_RS22145 (4348312)	4348312..4348905	+	594	WP_000991414.1	NAAT family transporter YhgN	-
G6O63_RS22150 (4348951)	4348951..4350153	-	1203	WP_001053680.1	DNA-processing protein DprA	Antitoxin
G6O63_RS22155 (4350153)	4350153..4350290	-	138	WP_001119379.1	hypothetical protein	Toxin
G6O63_RS22165 (4351089)	4351089..4352900	-	1812	WP_005140413.1	helicase-related protein	-
G6O63_RS22170 (4353041)	4353041..4354381	-	1341	WP_000210099.1	gluconate transporter	-
G6O63_RS22175 (4354385)	4354385..4354912	-	528	WP_000108330.1	gluconokinase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Phosphoribosyltransferase domain (6-34)

Antitoxin

• DNA recombination-mediator protein A (89-292)

Sequences

Toxin

Protein

• Length: 46 a.a.
• Molecular weight: 4683.50 Da
• Isoelectric Point: 4.3115

>T150808 WP_001119379.1 NZ_CP049177:c4350290-4350153 [Shigella sonnei]
MPGPALLVDDIVDSAWTLTVLTALLRQAGCPTVYPLALASTSVKN

Nucleotide

• Length: 138 bp

>T150808 NZ_CP065036:c1032293-1031973 [Pectobacterium parmentieri]
ATGCAAACATCACCGGCAATCCCGCCACGGGAGGATAACCCCTGTCCGTCACCTATAGCCGTCTGGCAGCAACTACTGAC
TTACCTGCTGGAAAAGCACTACGGCCTGACGCTGAACGACACACCATTCTGTGAGGAAAACGTGATTCAGGAGCATATCG
ATGCTGGCATCACGCTGGCCAATGCCGTCAATTTTCTGGTGGAGAAATACGAACTGGTGCGTATCGATCGCAACGGCTTT
AACTGGCAGGAGCAATCGCCGTTTCTTACCGCCGTTGATGTTCTCCGTGCTAGACGTGCAACGGGCTTGCTCAAGGCATA
A

Antitoxin

Protein

• Length: 401 a.a.
• Molecular weight: 43812.21 Da
• Isoelectric Point: 6.6429

>AT150808 WP_001053680.1 NZ_CP049177:c4350153-4348951 [Shigella sonnei]
MNLSANAQATLLLTSDFSRAAASEYKPLSNSEWGKFALWLKHQRISPAELLVPQPQEKLTGWSDPRISQERILGLLARGH
SLALAVDKWQRAGLWILTRGDADYPVRLKNRLRTDAPPVLFGCGNKALLQAEGMAIVGSRDAPTDDLRYTQQLAAKLAQQ
GICVISGGARGIDECAMASALEAGGTAVGVLADSLLKTSTLVKWREGLIAGNLVLISPFYPEVRFTVGNAMARNKYIYCL
AESAMVVRAGMTGGTITGAMEALKHQWLPVQVKPNQDMQSANSRLVENGASWSAEQAENVTIRLPDVPGLMYDRALRNAQ
PELFSLHEDDANYAVMPAYTPVDFYQLFVAELAILAKESISIERLASCTGLTIEQISVWLNRAEEEGRVIRLGEGHYQFR

Nucleotide

• Length: 1203 bp

>AT150808 NZ_CP065036:c1032698-1032363 [Pectobacterium parmentieri]
ATGCCATCATCGGATACCCCGGAGTGGGGATTAAAATGTGCCATCACGCCGCGATTCGGAGCCAGGCTGGTCCAGGAAGG
ACACCGCCTGCATTATCTGGAAGACCGGGCCAGCATTGTCGGTACGTTCAGCGAAATGGAAGCCCACCATCTGGAAGAGA
TCTTTCCTGAGCTGATTAAGCAGTTGGAACAAAAACTGCGCTCGGGTGAGTTGAATCCCCGTCAGCGGGGTTGCGTCACG
CTGTATTGTAACGAATGGACCTGTGAAGCCGATACGCTGGGCAGTTTTGGTTATGTATATATTGTTATTTATCCCACTTC
TGCAGCAACACACTAA

Structures

Antitoxin

• AlphaFold DB: A0A656BP16