Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3702223..3702877 Replicon chromosome
Accession NZ_CP049177
Organism Shigella sonnei strain 1205.3131

Toxin (Protein)


Gene name cptA Uniprot ID S1EEB2
Locus tag G6O63_RS18785 Protein ID WP_000244777.1
Coordinates 3702223..3702630 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag G6O63_RS18790 Protein ID WP_000354046.1
Coordinates 3702611..3702877 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6O63_RS18765 (3698180) 3698180..3699913 - 1734 WP_000813167.1 single-stranded-DNA-specific exonuclease RecJ -
G6O63_RS18770 (3699919) 3699919..3700629 - 711 WP_000715206.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
G6O63_RS18775 (3700654) 3700654..3701550 - 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
G6O63_RS18780 (3701662) 3701662..3702183 + 522 WP_001055874.1 flavodoxin FldB -
G6O63_RS18785 (3702223) 3702223..3702630 - 408 WP_000244777.1 protein YgfX Toxin
G6O63_RS18790 (3702611) 3702611..3702877 - 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
G6O63_RS18795 (3703120) 3703120..3704100 + 981 WP_000886060.1 tRNA-modifying protein YgfZ -
G6O63_RS18800 (3704296) 3704296..3704955 - 660 WP_000250274.1 hemolysin III family protein -
G6O63_RS18805 (3705119) 3705119..3705430 - 312 WP_001182954.1 N(4)-acetylcytidine aminohydrolase -
G6O63_RS18810 (3705475) 3705475..3706908 + 1434 WP_005137189.1 6-phospho-beta-glucosidase BglA -
G6O63_RS18815 (3706965) 3706965..3707708 - 744 WP_000951937.1 SDR family oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16031.96 Da        Isoelectric Point: 11.5202

>T150806 WP_000244777.1 NZ_CP049177:c3702630-3702223 [Shigella sonnei]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

>T150806 NZ_CP065036:c190881-190630 [Pectobacterium parmentieri]
ATGCGTACAATTAGCTACAGCGAAGCCCGCCAAAACCTATCAGCAACCATGATGAAAACGGTCGAAGACCGTGCTCCCAT
TCTTATCACCCGACAGAATGGCGAAGCCTGTGTGCTGATGTCTCTGGAAGAGTATAACTCTCTAGAAGAAACCGCGTATT
TACTGCGTTCTCCCGCCAATGCCAAAAGACTGATGAATGCAATCGAGAGCCTTAAGGCTGGCAATGGCGAAGAAAGAGAT
ATCATTGAGTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT150806 WP_000354046.1 NZ_CP049177:c3702877-3702611 [Shigella sonnei]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT150806 NZ_CP065036:c190633-190379 [Pectobacterium parmentieri]
GTGAAGCCAATCTGGTCAGAAGCAGCATGGGAAGACTACCTGTACTGGCAGGATATCGATAATCGGATAGTCAAAAAAAT
CAATGAATTAATAAAAGAAATTCGCAGAACGCCTTTTGAGGGAAAAGGAAAACCAGAGCCGCTTAAACATAATCTTGCTG
GCTTCTGGTCACGCCGTATCACCGAAGAACATCGTCTGGTCTATGCCATCACCGATGACGCCATGATGATCGCTGCCTGC
CGCTACCACTATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LFV7

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References