150802

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 2098601..2099085 Replicon chromosome
Accession NZ_CP049177
Organism Shigella sonnei strain 1205.3131

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A377EAU1
Locus tag G6O63_RS10505 Protein ID WP_014334020.1
Coordinates 2098601..2098891 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID A0A376K4R9
Locus tag G6O63_RS10510 Protein ID WP_005142544.1
Coordinates 2098891..2099085 (-) Length 65 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6O63_RS10470 (2093672) 2093672..2094286 - 615 WP_000148710.1 Tat proofreading chaperone DmsD -
G6O63_RS10475 (2094329) 2094329..2095183 - 855 WP_000526502.1 dimethyl sulfoxide reductase anchor subunit family protein -
G6O63_RS10480 (2095185) 2095185..2095802 - 618 WP_000213029.1 dimethylsulfoxide reductase subunit B -
G6O63_RS10485 (2095813) 2095813..2096889 - 1077 Protein_2043 molybdopterin dinucleotide binding domain-containing protein -
G6O63_RS10490 (2096947) 2096947..2097644 + 698 WP_237158184.1 IS1-like element IS1A family transposase -
G6O63_RS10495 (2097792) 2097792..2098157 - 366 WP_024174355.1 hypothetical protein -
G6O63_RS10500 (2098169) 2098169..2098321 - 153 WP_000379558.1 DUF1391 family protein -
G6O63_RS10505 (2098601) 2098601..2098891 - 291 WP_014334020.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
G6O63_RS10510 (2098891) 2098891..2099085 - 195 WP_005142544.1 hypothetical protein Antitoxin
G6O63_RS10515 (2099105) 2099105..2099590 - 486 WP_053002468.1 helix-turn-helix domain-containing protein -
G6O63_RS10520 (2099717) 2099717..2099980 + 264 WP_001048456.1 helix-turn-helix transcriptional regulator -
G6O63_RS10525 (2099977) 2099977..2100402 + 426 WP_000693826.1 toxin YdaT family protein -
G6O63_RS10530 (2100474) 2100474..2101538 + 1065 WP_001262380.1 hypothetical protein -
G6O63_RS10535 (2101545) 2101545..2102291 + 747 WP_000788740.1 ATP-binding protein -
G6O63_RS10540 (2102313) 2102313..2103038 + 726 WP_000450631.1 DUF1627 domain-containing protein -
G6O63_RS10545 (2103054) 2103054..2103476 + 423 WP_001151171.1 DUF977 family protein -
G6O63_RS10550 (2103534) 2103534..2103890 + 357 WP_005140877.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - sodB / rhs/PAAR / rhs/PAAR / vgrG/tssI 2006835..2234173 227338


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11062.93 Da        Isoelectric Point: 10.2013

>T150802 WP_014334020.1 NZ_CP049177:c2098891-2098601 [Shigella sonnei]
MLPVLWLPSARDDLRQIVAYIAKENPAAARRMKIRIETSVLPLTEHPYLYPPSERVLGLREIVTHPNYIILYRVTASSIE
VVNIVHSRRQYPGKNS

Download         Length: 291 bp

>T150802 NZ_CP065036:57242-57547 [Pectobacterium parmentieri]
GTGTTCTCCCGTGCACCTTTTGACACTGCAATCGCCCAATTCCCGAATCAGGCGGCAGCACTGGCTGACCTATACCGGAC
GATAAAGCGTGAAATATATGCAACGCCGGACGATATGAAAAAACGTTTCCCCAGCTTAGACAGGATGAAGTACAGGGAAA
AGTGGTGGGTTATTGATATTGGTGGTGGGCATCTTCGGGTGATGTTTTTCGCTGATTTTGAGCGAGGGAAAATTTTTATC
AAACACATCACATCCCATGCAGAGTACGGCAGTCTGACAGAATATTACCGGAGGAATAAAGAATGA

Antitoxin


Download         Length: 65 a.a.        Molecular weight: 7097.98 Da        Isoelectric Point: 4.1759

>AT150802 WP_005142544.1 NZ_CP049177:c2099085-2098891 [Shigella sonnei]
MSTVLSPMVSEFETVEQENSYNEWLRAKVAASLADPRPAIPHDEVMAEMEQIIAQIAAATHRGE

Download         Length: 195 bp

>AT150802 NZ_CP065036:57544-57867 [Pectobacterium parmentieri]
ATGATGTACGCAGACGCAATCAAGGCCGCTAACAATCTGACGAGTATCGTACCGCTCCTCGGAGGTAGCACCTCTTGTAA
AGATTATGAGGATGCGCCAGAGTTTGTAGCTTTCAACGAGCGTATTAAAGCGCTCCCTGCTGGTATCGCTTTGCTGCGCA
TACTTATGGATCAGCATGGGCTAACGCAAAGTGACTTTGAAGCTGAGATCGGTAAAAAATCTCTGGTATCCCGAATTCTA
AATGGTGAGCGTACACTAACGGTTGATCACATGAGCGCACTTGCTAAACGATTTGATATTCCCGTGAGTGCTTTTGTTGA
TTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A377EAU1

Antitoxin

Source ID Structure
AlphaFold DB A0A376K4R9

References