Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 913879..914497 Replicon chromosome
Accession NZ_CP049177
Organism Shigella sonnei strain 1205.3131

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag G6O63_RS04465 Protein ID WP_001291435.1
Coordinates 913879..914097 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A0H8V4S8
Locus tag G6O63_RS04470 Protein ID WP_000344804.1
Coordinates 914123..914497 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6O63_RS04430 (909171) 909171..909743 + 573 WP_000779812.1 YbaY family lipoprotein -
G6O63_RS04435 (909774) 909774..910085 - 312 WP_000409911.1 MGMT family protein -
G6O63_RS04445 (910464) 910464..910817 + 354 WP_000878140.1 DUF1428 domain-containing protein -
G6O63_RS04450 (910859) 910859..912407 - 1549 Protein_860 cyclic-guanylate-specific phosphodiesterase PdeB -
G6O63_RS04455 (912571) 912571..913041 - 471 WP_000136192.1 YlaC family protein -
G6O63_RS04460 (913157) 913157..913708 - 552 WP_000102564.1 maltose O-acetyltransferase -
G6O63_RS04465 (913879) 913879..914097 - 219 WP_001291435.1 HHA domain-containing protein Toxin
G6O63_RS04470 (914123) 914123..914497 - 375 WP_000344804.1 Hha toxicity modulator TomB Antitoxin
G6O63_RS04475 (915043) 915043..918192 - 3150 WP_001132464.1 efflux RND transporter permease AcrB -
G6O63_RS04480 (918215) 918215..919408 - 1194 WP_011310152.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T150793 WP_001291435.1 NZ_CP049177:c914097-913879 [Shigella sonnei]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T150793 NZ_CP065034:794360-794770 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAAATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14615.43 Da        Isoelectric Point: 4.6232

>AT150793 WP_000344804.1 NZ_CP049177:c914497-914123 [Shigella sonnei]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIETFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT150793 NZ_CP065034:794113-794379 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H8V4S8

References