Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) itaRT/DUF1778(antitoxin)
Location 876186..877023 Replicon chromosome
Accession NZ_CP049177
Organism Shigella sonnei strain 1205.3131

Toxin (Protein)


Gene name itaT Uniprot ID Q3Z4X7
Locus tag G6O63_RS04270 Protein ID WP_000227784.1
Coordinates 876186..876728 (-) Length 181 a.a.

Antitoxin (Protein)


Gene name itaR Uniprot ID I2UQS9
Locus tag G6O63_RS04275 Protein ID WP_001297137.1
Coordinates 876712..877023 (-) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6O63_RS04240 (871250) 871250..871741 + 492 WP_001138904.1 nucleotide binding protein YajQ -
G6O63_RS04245 (871869) 871869..873233 - 1365 WP_001000971.1 MFS transporter -
G6O63_RS04250 (873352) 873352..874049 + 698 WP_237158184.1 IS1-like element IS1A family transposase -
G6O63_RS04255 (874418) 874418..874816 + 399 Protein_822 SEL1-like repeat protein -
G6O63_RS04265 (875564) 875564..876130 + 567 Protein_824 SEL1-like repeat protein -
G6O63_RS04270 (876186) 876186..876728 - 543 WP_000227784.1 GNAT family N-acetyltransferase Toxin
G6O63_RS04275 (876712) 876712..877023 - 312 WP_001297137.1 DUF1778 domain-containing protein Antitoxin
G6O63_RS04280 (877208) 877208..878098 - 891 WP_000971327.1 heme o synthase -
G6O63_RS04285 (878110) 878110..878439 - 330 WP_000019869.1 cytochrome o ubiquinol oxidase subunit IV -
G6O63_RS04290 (878439) 878439..879053 - 615 WP_000179819.1 cytochrome o ubiquinol oxidase subunit III -
G6O63_RS04295 (879043) 879043..881034 - 1992 WP_000467180.1 cytochrome o ubiquinol oxidase subunit I -
G6O63_RS04300 (881056) 881056..882003 - 948 WP_001239441.1 cytochrome o ubiquinol oxidase subunit II -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(68-156)

Antitoxin

Vibrio phage ICP1, Orf50

(14-97)


Sequences

Toxin        


Download         Length: 181 a.a.        Molecular weight: 19805.02 Da        Isoelectric Point: 8.3395

>T150792 WP_000227784.1 NZ_CP049177:c876728-876186 [Shigella sonnei]
MVDKHEEITLPIVLSCNYQSDITYPGQKQFDCGNPVIDKFVRASLKKSVRNSDCAAKALIDRQSGELIGICTFTAYSLEK
QRVSGVLQGSQPSEIGVVRLVMLGVARKYQKRGFGQDLLCDFFEHVKIIHQALPIKGVYLDADPAAINFYARLGFVQLSA
TPNAFGAVPMFLAIQHILAA

Download         Length: 543 bp

>T150792 NZ_CP065034:660983-661324 [Klebsiella pneumoniae]
ATGAAAACTCTACCTGCTACAATTTCGCGGGCGGCGAAGCCCTGTCTGTCGCCCGTGGCTGTCTGGCAAATGTTACTGAC
ACGCCTGCTGGAACAGCACTATGGCCTGACACTGAACGACACGCCGTTCAGTGATGAAACTGTTATTAAGGAACATATTG
ATGCCGGGATTACCCTGGCCGATGCAGTCAACTTCCTGGTGGATAAGTACGAACTGGTTCGTATCGATCGCAGGGGGTTT
AACTGGCAGGAGCAATCCCCTTATCTTCGGGCGGTAGATATCCTGCGAGCACGACAAGCAATTGGCTTGTTGCGACGGAG
CCGTAATAACGCTGTATTGTGA

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11358.04 Da        Isoelectric Point: 10.4825

>AT150792 WP_001297137.1 NZ_CP049177:c877023-876712 [Shigella sonnei]
MPGKTATLPDVDKTLKNARVELKTSPDAKNKLREAAQAVGVDLSAFILSAAMERAESVLDNQRRRELSNQSWELMNQLIA
EPAQPTLALKALMKRKNSDGRQA

Download         Length: 312 bp

>AT150792 NZ_CP065034:660642-660962 [Klebsiella pneumoniae]
ATGAGCAGTAATGTCACATGGGGACTGCAGCGGGATAACACGCCGCGCCTGGGAGCCCGTCTGGTACAGGAGGGCAACCG
GCTGCACTATCTGGCTGACCGGGCAAGCATCACTGGTAAATTAAGTGACGCCGAATGCCGGAGGCTGGATGAAACATTCC
CGCACTTTATCAGTCAGATGGAGTCGATGCTGACCACCGATGAACTGAATCCCCGTCATGCCCACTGCGTCACCCTGTAC
CACAACGGTTTTACCTGCGAAGCCGAAACTCTTGGCAGTTGCGGCTACGTATACATCGCCATTTACCCCACTCAGCGTTA
A

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7BYY

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0Y6B3

References