Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | paaR-paaA-parE/- |
| Location | 4843024..4843508 | Replicon | chromosome |
| Accession | NZ_CP049175 | ||
| Organism | Shigella sonnei strain 7111.69 | ||
Toxin (Protein)
| Gene name | parE_1 | Uniprot ID | A0A377EAU1 |
| Locus tag | G6O62_RS24530 | Protein ID | WP_014334020.1 |
| Coordinates | 4843218..4843508 (+) | Length | 97 a.a. |
Antitoxin (Protein)
| Gene name | paaA | Uniprot ID | A0A376K4R9 |
| Locus tag | G6O62_RS24525 | Protein ID | WP_005142544.1 |
| Coordinates | 4843024..4843218 (+) | Length | 65 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| G6O62_RS24485 (4838219) | 4838219..4838575 | - | 357 | WP_005140877.1 | hypothetical protein | - |
| G6O62_RS24490 (4838633) | 4838633..4839055 | - | 423 | WP_001151171.1 | DUF977 family protein | - |
| G6O62_RS24495 (4839071) | 4839071..4839796 | - | 726 | WP_000450631.1 | DUF1627 domain-containing protein | - |
| G6O62_RS24500 (4839818) | 4839818..4840564 | - | 747 | WP_000788740.1 | ATP-binding protein | - |
| G6O62_RS24505 (4840571) | 4840571..4841635 | - | 1065 | WP_001262380.1 | hypothetical protein | - |
| G6O62_RS24510 (4841707) | 4841707..4842132 | - | 426 | WP_000693826.1 | toxin YdaT family protein | - |
| G6O62_RS24515 (4842129) | 4842129..4842392 | - | 264 | WP_001048456.1 | helix-turn-helix transcriptional regulator | - |
| G6O62_RS24520 (4842519) | 4842519..4843004 | + | 486 | WP_053002468.1 | helix-turn-helix domain-containing protein | - |
| G6O62_RS24525 (4843024) | 4843024..4843218 | + | 195 | WP_005142544.1 | hypothetical protein | Antitoxin |
| G6O62_RS24530 (4843218) | 4843218..4843508 | + | 291 | WP_014334020.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| G6O62_RS24535 (4843788) | 4843788..4843940 | + | 153 | WP_000379558.1 | DUF1391 family protein | - |
| G6O62_RS24540 (4843952) | 4843952..4844317 | + | 366 | WP_024174355.1 | hypothetical protein | - |
| G6O62_RS24550 (4845220) | 4845220..4846296 | + | 1077 | Protein_4777 | molybdopterin-dependent oxidoreductase | - |
| G6O62_RS24555 (4846307) | 4846307..4846924 | + | 618 | WP_000213029.1 | dimethylsulfoxide reductase subunit B | - |
| G6O62_RS24560 (4846926) | 4846926..4847780 | + | 855 | WP_000526502.1 | dimethyl sulfoxide reductase anchor subunit family protein | - |
| G6O62_RS24565 (4847823) | 4847823..4848437 | + | 615 | WP_000148710.1 | Tat proofreading chaperone DmsD | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 4825232..4844789 | 19557 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 97 a.a. Molecular weight: 11062.93 Da Isoelectric Point: 10.2013
>T150785 WP_014334020.1 NZ_CP049175:4843218-4843508 [Shigella sonnei]
MLPVLWLPSARDDLRQIVAYIAKENPAAARRMKIRIETSVLPLTEHPYLYPPSERVLGLREIVTHPNYIILYRVTASSIE
VVNIVHSRRQYPGKNS
MLPVLWLPSARDDLRQIVAYIAKENPAAARRMKIRIETSVLPLTEHPYLYPPSERVLGLREIVTHPNYIILYRVTASSIE
VVNIVHSRRQYPGKNS
Download Length: 291 bp
>T150785 NZ_CP065032:c3195154-3194801 [Serratia sp. CMO1]
GTGTGGGAAATTAAAACAACGGATGCATTTGATCATTGGTTCAGATCACTCAGCGATGCCGATCGGGCCGGCGTACTTGC
CGCATTGATGGTCCTGCGGGAAAAGGGGCCGGGGTTGCCCAGACCCTATGCCGATACGGTTAAAGGCTCACGTTACAGCA
ATATGAAAGAGTTGCGCATTCAGTGCCGAGGCGAACCGTTGCGGGCATTCTTCGCTTTCGATCCGTACCGTATTGGCATT
GTGCTTTGCGCGGGCAATAAAGCCGGTAATGAAAGGCGTTTTTACGATGGGATGATCCAGGTTGCCGATCGGGAATTCAC
GAACTGGCTGAACACATTAAACGAGAAGGAGTGA
GTGTGGGAAATTAAAACAACGGATGCATTTGATCATTGGTTCAGATCACTCAGCGATGCCGATCGGGCCGGCGTACTTGC
CGCATTGATGGTCCTGCGGGAAAAGGGGCCGGGGTTGCCCAGACCCTATGCCGATACGGTTAAAGGCTCACGTTACAGCA
ATATGAAAGAGTTGCGCATTCAGTGCCGAGGCGAACCGTTGCGGGCATTCTTCGCTTTCGATCCGTACCGTATTGGCATT
GTGCTTTGCGCGGGCAATAAAGCCGGTAATGAAAGGCGTTTTTACGATGGGATGATCCAGGTTGCCGATCGGGAATTCAC
GAACTGGCTGAACACATTAAACGAGAAGGAGTGA
Antitoxin
Download Length: 65 a.a. Molecular weight: 7097.98 Da Isoelectric Point: 4.1759
>AT150785 WP_005142544.1 NZ_CP049175:4843024-4843218 [Shigella sonnei]
MSTVLSPMVSEFETVEQENSYNEWLRAKVAASLADPRPAIPHDEVMAEMEQIIAQIAAATHRGE
MSTVLSPMVSEFETVEQENSYNEWLRAKVAASLADPRPAIPHDEVMAEMEQIIAQIAAATHRGE
Download Length: 195 bp
>AT150785 NZ_CP065032:c3194796-3194494 [Serratia sp. CMO1]
ATGGGCAGAACGTTGGAACAGCTTATTGCGGATGAAAAGCCCGAGGTCGTGGCCAAAGCGCAGGCGCTGGCGGCGGACAT
CATGCTGAACATTCACCTTGCCGAGCTGCGTGAAAAAGTACAGAAAACGCAGGTTGAAATGGCGCAGGCGCTGGGGATCA
GGCAGCCGACCGTTGCCGTGATGGAAAAACCGGGCCGCGATCTGAAACTGTCTTCGCTTAAACGCTATGTTGAGGCGGCC
GGCGGCAAACTGCGCCTGGACATTGAACTGCCGGACGGCTCTCACTACGAGTTTGTGCTGTAA
ATGGGCAGAACGTTGGAACAGCTTATTGCGGATGAAAAGCCCGAGGTCGTGGCCAAAGCGCAGGCGCTGGCGGCGGACAT
CATGCTGAACATTCACCTTGCCGAGCTGCGTGAAAAAGTACAGAAAACGCAGGTTGAAATGGCGCAGGCGCTGGGGATCA
GGCAGCCGACCGTTGCCGTGATGGAAAAACCGGGCCGCGATCTGAAACTGTCTTCGCTTAAACGCTATGTTGAGGCGGCC
GGCGGCAAACTGCGCCTGGACATTGAACTGCCGGACGGCTCTCACTACGAGTTTGTGCTGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A377EAU1 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A376K4R9 |