Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3239569..3240223 Replicon chromosome
Accession NZ_CP049175
Organism Shigella sonnei strain 7111.69

Toxin (Protein)


Gene name cptA Uniprot ID S1EEB2
Locus tag G6O62_RS16260 Protein ID WP_000244777.1
Coordinates 3239816..3240223 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag G6O62_RS16255 Protein ID WP_000354046.1
Coordinates 3239569..3239835 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6O62_RS16230 (3234738) 3234738..3235481 + 744 WP_000951937.1 SDR family oxidoreductase -
G6O62_RS16235 (3235538) 3235538..3236971 - 1434 WP_005137189.1 6-phospho-beta-glucosidase BglA -
G6O62_RS16240 (3237016) 3237016..3237327 + 312 WP_001182954.1 N(4)-acetylcytidine aminohydrolase -
G6O62_RS16245 (3237491) 3237491..3238150 + 660 WP_000250274.1 hemolysin III family protein -
G6O62_RS16250 (3238346) 3238346..3239326 - 981 WP_000886060.1 tRNA-modifying protein YgfZ -
G6O62_RS16255 (3239569) 3239569..3239835 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
G6O62_RS16260 (3239816) 3239816..3240223 + 408 WP_000244777.1 protein YgfX Toxin
G6O62_RS16265 (3240263) 3240263..3240784 - 522 WP_001055874.1 flavodoxin FldB -
G6O62_RS16270 (3240896) 3240896..3241792 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
G6O62_RS16275 (3241817) 3241817..3242527 + 711 WP_000715206.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
G6O62_RS16280 (3242533) 3242533..3244266 + 1734 WP_000813167.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16031.96 Da        Isoelectric Point: 11.5202

>T150781 WP_000244777.1 NZ_CP049175:3239816-3240223 [Shigella sonnei]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

>T150781 NZ_CP065032:c1032797-1032594 [Serratia sp. CMO1]
ATGACTAAAACCGACTATCTGATGCGTTTACGTAAATGCACCACGATTGATACTCTCGAACGTGTTATTGAGAAAAATAA
GTACGAGCTTTCCGATGATGAACTGGAGCTGTTTTACTCAGCGGCCGATCACCGTCTGGCAGAGCTCACCATGAACAAAC
TGTATGACAAAATCCCCACCTCCGTTTGGAAATATGTCAGATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT150781 WP_000354046.1 NZ_CP049175:3239569-3239835 [Shigella sonnei]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT150781 NZ_CP065032:c1033215-1032847 [Serratia sp. CMO1]
ATGGATGAGTATTCGCCTAAGCGGCACGACATTGCTCAGCTCAAATTCTTGTGCGAAAATTTGTATGATGAAGGTATCGC
TACCCTGGGAGACAGTCATCATGGGTGGGTCAACGATCCGACGTCCTCCGTCAACCTGCAGCTTAATGAGTTGATCGAAC
ATATCGCTTCGTTTGTGATGAGTTATAAAATTAAATACATGGACGAATCTGACCTGTCGGAGTTAGTCGAAGAATATCTC
GACGATACCTATACGCTGTTCAGCAGCTATGGTATCAATGATTCCGACCTGCGCCGCTGGCAAAAAACCAAGGCGAGATT
ATTCAGAATGTTCTCAGGAGAGGACATCTGTACGACAATGAAAACTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LFV7

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References