Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) itaRT/DUF1778(antitoxin)
Location 1184091..1184928 Replicon chromosome
Accession NZ_CP049175
Organism Shigella sonnei strain 7111.69

Toxin (Protein)


Gene name itaT Uniprot ID Q3Z4X7
Locus tag G6O62_RS06075 Protein ID WP_000227784.1
Coordinates 1184386..1184928 (+) Length 181 a.a.

Antitoxin (Protein)


Gene name itaR Uniprot ID I2UQS9
Locus tag G6O62_RS06070 Protein ID WP_001297137.1
Coordinates 1184091..1184402 (+) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6O62_RS06045 (1179111) 1179111..1180058 + 948 WP_001239441.1 cytochrome o ubiquinol oxidase subunit II -
G6O62_RS06050 (1180080) 1180080..1182071 + 1992 WP_000467180.1 cytochrome o ubiquinol oxidase subunit I -
G6O62_RS06055 (1182061) 1182061..1182675 + 615 WP_000179819.1 cytochrome o ubiquinol oxidase subunit III -
G6O62_RS06060 (1182675) 1182675..1183004 + 330 WP_000019869.1 cytochrome o ubiquinol oxidase subunit IV -
G6O62_RS06065 (1183016) 1183016..1183906 + 891 WP_000971327.1 heme o synthase -
G6O62_RS06070 (1184091) 1184091..1184402 + 312 WP_001297137.1 DUF1778 domain-containing protein Antitoxin
G6O62_RS06075 (1184386) 1184386..1184928 + 543 WP_000227784.1 GNAT family N-acetyltransferase Toxin
G6O62_RS06080 (1184984) 1184984..1185550 - 567 Protein_1188 SEL1-like repeat protein -
G6O62_RS06085 (1185584) 1185584..1186281 + 698 WP_237158184.1 IS1-like element IS1A family transposase -
G6O62_RS06090 (1186298) 1186298..1186696 - 399 Protein_1190 SEL1-like repeat protein -
G6O62_RS06100 (1187881) 1187881..1189245 + 1365 WP_001000971.1 MFS transporter -
G6O62_RS06105 (1189373) 1189373..1189864 - 492 WP_001138904.1 nucleotide binding protein YajQ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(68-156)

Antitoxin

Vibrio phage ICP1, Orf50

(14-97)


Sequences

Toxin        


Download         Length: 181 a.a.        Molecular weight: 19805.02 Da        Isoelectric Point: 8.3395

>T150777 WP_000227784.1 NZ_CP049175:1184386-1184928 [Shigella sonnei]
MVDKHEEITLPIVLSCNYQSDITYPGQKQFDCGNPVIDKFVRASLKKSVRNSDCAAKALIDRQSGELIGICTFTAYSLEK
QRVSGVLQGSQPSEIGVVRLVMLGVARKYQKRGFGQDLLCDFFEHVKIIHQALPIKGVYLDADPAAINFYARLGFVQLSA
TPNAFGAVPMFLAIQHILAA

Download         Length: 543 bp

>T150777 NZ_CP065031:c4496860-4496585 [Pectobacterium brasiliense]
ATGGAAATACGTTGGACGCAAAAGGCACAGGATGACCTGGAACGTATTTATGGGTTTGCCAGCCAGTACAGTCGGCAACA
TGCTGACGAGGTGTTAGATCGTTTGATCATCGGCACCACGGGGCTTGCTGACTACCCGAGAATCGGCGTATCTCAGACAA
GGTATGAACCACGTGAGGTGAGAAAGATTTTGTTTGATGATTATGAAGTTCACTATGAAATTCAGCATGATACGAGTTAT
ATCGTCGATCTGTGGCATAAACGAGAAGACCGCTAA

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11358.04 Da        Isoelectric Point: 10.4825

>AT150777 WP_001297137.1 NZ_CP049175:1184091-1184402 [Shigella sonnei]
MPGKTATLPDVDKTLKNARVELKTSPDAKNKLREAAQAVGVDLSAFILSAAMERAESVLDNQRRRELSNQSWELMNQLIA
EPAQPTLALKALMKRKNSDGRQA

Download         Length: 312 bp

>AT150777 NZ_CP065031:c4497112-4496864 [Pectobacterium brasiliense]
ATGGGACAACCCGCGAAACAGACGATCAGTGCTCAGATACCCGCCGAACTTGCGGCTGCGGTTGAAAGACTGGCTATTGA
ATTGGATAGATCCAAAAGCTGGGTGATTAAAGAAGCGCTGACCGCAATGATTGAAGAGAGAGAGCGGCGGCATCAGCGGA
TTTTGAAAGGTCTTGCTGATGTCGATGCGGGAAGAGTAGTAAGCCATGCAGATGTGATCGACTTCGCCAACAAACTGAAA
AAGTCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7BYY

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0Y6B3

References