Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1146615..1147233 Replicon chromosome
Accession NZ_CP049175
Organism Shigella sonnei strain 7111.69

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag G6O62_RS05880 Protein ID WP_001291435.1
Coordinates 1147015..1147233 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A0H8V4S8
Locus tag G6O62_RS05875 Protein ID WP_000344804.1
Coordinates 1146615..1146989 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6O62_RS05865 (1141704) 1141704..1142897 + 1194 WP_011310152.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
G6O62_RS05870 (1142920) 1142920..1146069 + 3150 WP_001132464.1 efflux RND transporter permease AcrB -
G6O62_RS05875 (1146615) 1146615..1146989 + 375 WP_000344804.1 Hha toxicity modulator TomB Antitoxin
G6O62_RS05880 (1147015) 1147015..1147233 + 219 WP_001291435.1 HHA domain-containing protein Toxin
G6O62_RS05885 (1147404) 1147404..1147955 + 552 WP_000102564.1 maltose O-acetyltransferase -
G6O62_RS05890 (1148071) 1148071..1148541 + 471 WP_000136192.1 YlaC family protein -
G6O62_RS05895 (1148705) 1148705..1150253 + 1549 Protein_1152 cyclic-guanylate-specific phosphodiesterase PdeB -
G6O62_RS05900 (1150295) 1150295..1150648 - 354 WP_000878140.1 DUF1428 domain-containing protein -
G6O62_RS05910 (1151027) 1151027..1151338 + 312 WP_000409911.1 MGMT family protein -
G6O62_RS05915 (1151369) 1151369..1151941 - 573 WP_000779812.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T150776 WP_001291435.1 NZ_CP049175:1147015-1147233 [Shigella sonnei]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T150776 NZ_CP065031:c4441863-4441558 [Pectobacterium brasiliense]
ATGCCACAAGTGATTGTTTCAGAACGTGCAAGACGTGATTTGCAACGTCTGCAGGATTTTCTAAAAAACAAAAATGCGCT
GGCTGCGAAAAAGGCGGCTGAAGTTTTGATTCGGGGCATTCGTCAGTTAGAAGCGCTGCCGAATATCGGGCGACCCGTTG
AACATCTCCCTCTTGAATATCAGGAACTGGTGATCGAATTCGGCAGCAGCGGGTACGTGGTGCTTTACCGCCATGATGAA
CTGACTGACAGAGTGGTGATCCTGACCGTCAAGCATCAAAAAGAAGCCGGTTACCAAAACCCTTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14615.43 Da        Isoelectric Point: 4.6232

>AT150776 WP_000344804.1 NZ_CP049175:1146615-1146989 [Shigella sonnei]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIETFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT150776 NZ_CP065031:c4442141-4441851 [Pectobacterium brasiliense]
ATGGCTGACACGCCACGCCAAACCACGACGCTGCGCATCGATCAGGACATTAAAGAACGACTGAAAACGTTGGCCGATGA
CCGCCATAGCTCAGCCCATGCGCTAATGCTGGAAGCCATCACCGAATACGTGGAGCGTGAAGAAAAACGCAGTCAGTACC
GTAAAGAGGCGCTGGCCGCGTGGGAGGAATACCAGAGCACCGGCGAACACATCACCGCCGATGAGACGGTCACCTGGTTA
GAATCCTGGGGTTCTGGGCATGAACAGGATGCGCCTGCATGCCACAAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H8V4S8

References