Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 2469795..2470413 Replicon chromosome
Accession NZ_CP049173
Organism Shigella sonnei strain 19.0820.1561

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag G6O61_RS12725 Protein ID WP_001291435.1
Coordinates 2470195..2470413 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A0H8V4S8
Locus tag G6O61_RS12720 Protein ID WP_000344804.1
Coordinates 2469795..2470169 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6O61_RS12710 (2464884) 2464884..2466077 + 1194 WP_011310152.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
G6O61_RS12715 (2466100) 2466100..2469249 + 3150 WP_001132464.1 efflux RND transporter permease AcrB -
G6O61_RS12720 (2469795) 2469795..2470169 + 375 WP_000344804.1 Hha toxicity modulator TomB Antitoxin
G6O61_RS12725 (2470195) 2470195..2470413 + 219 WP_001291435.1 HHA domain-containing protein Toxin
G6O61_RS12730 (2470584) 2470584..2471135 + 552 WP_000102564.1 maltose O-acetyltransferase -
G6O61_RS12735 (2471251) 2471251..2471721 + 471 WP_000136192.1 YlaC family protein -
G6O61_RS12740 (2471885) 2471885..2473433 + 1549 Protein_2488 cyclic-guanylate-specific phosphodiesterase PdeB -
G6O61_RS12745 (2473475) 2473475..2473828 - 354 WP_000878140.1 DUF1428 domain-containing protein -
G6O61_RS12755 (2474207) 2474207..2474518 + 312 WP_000409911.1 MGMT family protein -
G6O61_RS12760 (2474549) 2474549..2475121 - 573 WP_000779812.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T150757 WP_001291435.1 NZ_CP049173:2470195-2470413 [Shigella sonnei]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T150757 NZ_CP065030:1496063-1496341 [Pectobacterium versatile]
ATGAAAAAGCAAAGGGAGATTGCATATTCTGGTCAATTCCAACGTGATGTGAAAAAAGCGCAACGGCGACATAAAAACAT
GAACAAGCTTAAAACGCTTATGCAGCTTTTGCTTGAAGACAAACGACCGTTGCCACAGGAATATCAGGATCATCCCCTCC
AGGGAAACTATAAGGGCTACAGAGATGCGCATATCGAGCCGGATTGGCTTCTTATTTACAAGCTGACCGATGACGTTTTG
CGTTTTGAACGTACAGGGACGCACGCTGACCTTTTCTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14615.43 Da        Isoelectric Point: 4.6232

>AT150757 WP_000344804.1 NZ_CP049173:2469795-2470169 [Shigella sonnei]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIETFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT150757 NZ_CP065030:1495799-1496059 [Pectobacterium versatile]
ATGGCAGCGAATGCATTTGTACGTGCCCGTATTGATGAGAATCTTAAAAATGAAGCAGCGGAAGTGTTGGCTAGCATGGG
GTTGACGGTATCGGATCTGGTGCGCATAACGTTAACGAAAGTGGCTAAAGAAAAAGCACTTCCATTTGATATGCATGTCC
CTAATAAGCTTACCGCACAAACGATGGCTGACAGCGAGAAAGGGGTTGATGTCCATACAGCAAAAGACGCCGCCGATCTG
TTTGATAAATTAGGGATCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H8V4S8

References