Detailed information of TA system TA150748

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): paaR-paaA-parE/-
• Location: 1290891..1291375
• Replicon: chromosome
• Accession: NZ_CP049173
• Organism: Shigella sonnei strain 19.0820.1561

Toxin (Protein)

• Gene name: parE_1
• Uniprot ID: A0A377EAU1
• Locus tag: G6O61_RS06705
• Protein ID: WP_014334020.1
• Coordinates: 1291085..1291375 (+)
• Length: 97 a.a.

Antitoxin (Protein)

• Gene name: paaA
• Uniprot ID: A0A376K4R9
• Locus tag: G6O61_RS06700
• Protein ID: WP_005142544.1
• Coordinates: 1290891..1291085 (+)
• Length: 65 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
G6O61_RS06660 (1286086)	1286086..1286442	-	357	WP_005140877.1	hypothetical protein	-
G6O61_RS06665 (1286500)	1286500..1286922	-	423	WP_001151171.1	DUF977 family protein	-
G6O61_RS06670 (1286938)	1286938..1287663	-	726	WP_000450631.1	DUF1627 domain-containing protein	-
G6O61_RS06675 (1287685)	1287685..1288431	-	747	WP_000788740.1	ATP-binding protein	-
G6O61_RS06680 (1288438)	1288438..1289502	-	1065	WP_039063478.1	phage replisome organizer	-
G6O61_RS06685 (1289574)	1289574..1289999	-	426	WP_000693826.1	toxin YdaT family protein	-
G6O61_RS06690 (1289996)	1289996..1290259	-	264	WP_001048456.1	helix-turn-helix transcriptional regulator	-
G6O61_RS06695 (1290386)	1290386..1290871	+	486	WP_053002468.1	helix-turn-helix domain-containing protein	-
G6O61_RS06700 (1290891)	1290891..1291085	+	195	WP_005142544.1	hypothetical protein	Antitoxin
G6O61_RS06705 (1291085)	1291085..1291375	+	291	WP_014334020.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
G6O61_RS06710 (1291655)	1291655..1291807	+	153	WP_000379558.1	DUF1391 family protein	-
G6O61_RS06715 (1291819)	1291819..1292184	+	366	WP_024174355.1	hypothetical protein	-
G6O61_RS06725 (1293562)	1293562..1294350	+	789	Protein_1311	Rha family transcriptional regulator	-
G6O61_RS06735 (1295099)	1295099..1296175	+	1077	Protein_1313	molybdopterin-dependent oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1284039..1296175	12136

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-91)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 97 a.a.
• Molecular weight: 11062.93 Da
• Isoelectric Point: 10.2013

>T150748 WP_014334020.1 NZ_CP049173:1291085-1291375 [Shigella sonnei]
MLPVLWLPSARDDLRQIVAYIAKENPAAARRMKIRIETSVLPLTEHPYLYPPSERVLGLREIVTHPNYIILYRVTASSIE
VVNIVHSRRQYPGKNS

Nucleotide

• Length: 291 bp

>T150748 NZ_CP065030:338256-338543 [Pectobacterium versatile]
ATGACCTATAAGTTAAAATTTGTGCCTTCTGCATTGAAGGAATGGAAAAAATTAGGGCACCCTGTCCGGGAGCAGTTCAA
GAAAAAGCTGGTTGAGCGTTTGGAAGATCCTCGTGTTCCTTCAGCCCAACTTCATGGTCGTAAAGACCAGTATAAAATTA
AACTGAAGTCCGCTGGCTACAGGCTGGTGTATTTGGTCCAGGATGAGACCATTACTGTGATGGTTATGGGCGTTGGAAAG
CGCGAAGGTAGCCAGATTTATTCTGATACTAAAGGTCGCTCTGCTTAA

Antitoxin

Protein

• Length: 65 a.a.
• Molecular weight: 7097.98 Da
• Isoelectric Point: 4.1759

>AT150748 WP_005142544.1 NZ_CP049173:1290891-1291085 [Shigella sonnei]
MSTVLSPMVSEFETVEQENSYNEWLRAKVAASLADPRPAIPHDEVMAEMEQIIAQIAAATHRGE

Nucleotide

• Length: 195 bp

>AT150748 NZ_CP065030:338012-338266 [Pectobacterium versatile]
ATGGCTTTCAACATCCTGACTAACACAGCCGCCAGTATTACTGAGTTGAAACGTGACCCGATGGGGACGGTACGGGCTGC
TGAAGGTGAAACTATCGCTATACTGAACCGGAATGAGCCGGCGTTCTACTGTGTGCCTCCTGCCGTATTCGCTTATTTAA
TGGAACTGGCTGAAGATGCCGAACTGGGGCGTACCGTTGATGACCGGATGTCAGAACTAGCTGACGCGGAAGAGATTTCG
CCCGATGACCTATAA

Structures

Toxin

• AlphaFold DB: A0A377EAU1

Antitoxin

• AlphaFold DB: A0A376K4R9