Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 4088034..4088518 Replicon chromosome
Accession NZ_CP049171
Organism Shigella sonnei strain 0401930105

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A377EAU1
Locus tag G6O59_RS20445 Protein ID WP_014334020.1
Coordinates 4088034..4088324 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID A0A376K4R9
Locus tag G6O59_RS20450 Protein ID WP_005142544.1
Coordinates 4088324..4088518 (-) Length 65 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6O59_RS20415 (4083234) 4083234..4084310 - 1077 Protein_3969 molybdopterin-dependent oxidoreductase -
G6O59_RS20420 (4084368) 4084368..4085065 + 698 WP_237158184.1 IS1-like element IS1A family transposase -
G6O59_RS20425 (4085059) 4085059..4085847 - 789 Protein_3971 Rha family transcriptional regulator -
G6O59_RS20430 (4086380) 4086380..4087077 + 698 WP_094096600.1 IS1-like element IS1A family transposase -
G6O59_RS20435 (4087225) 4087225..4087590 - 366 WP_024174355.1 hypothetical protein -
G6O59_RS20440 (4087602) 4087602..4087754 - 153 WP_000379558.1 DUF1391 family protein -
G6O59_RS20445 (4088034) 4088034..4088324 - 291 WP_014334020.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
G6O59_RS20450 (4088324) 4088324..4088518 - 195 WP_005142544.1 hypothetical protein Antitoxin
G6O59_RS20455 (4088538) 4088538..4089023 - 486 WP_053002468.1 helix-turn-helix domain-containing protein -
G6O59_RS20460 (4089150) 4089150..4089413 + 264 WP_001048456.1 helix-turn-helix transcriptional regulator -
G6O59_RS20465 (4089410) 4089410..4089835 + 426 WP_000693826.1 toxin YdaT family protein -
G6O59_RS20470 (4089907) 4089907..4090971 + 1065 WP_001262380.1 hypothetical protein -
G6O59_RS20475 (4090978) 4090978..4091724 + 747 WP_000788740.1 ATP-binding protein -
G6O59_RS20480 (4091746) 4091746..4092471 + 726 WP_000450631.1 DUF1627 domain-containing protein -
G6O59_RS20485 (4092487) 4092487..4092909 + 423 WP_001151171.1 DUF977 family protein -
G6O59_RS20490 (4092967) 4092967..4093323 + 357 WP_005140877.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - sodB / rhs/PAAR / rhs/PAAR / vgrG/tssI 3994294..4264839 270545


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11062.93 Da        Isoelectric Point: 10.2013

>T150742 WP_014334020.1 NZ_CP049171:c4088324-4088034 [Shigella sonnei]
MLPVLWLPSARDDLRQIVAYIAKENPAAARRMKIRIETSVLPLTEHPYLYPPSERVLGLREIVTHPNYIILYRVTASSIE
VVNIVHSRRQYPGKNS

Download         Length: 291 bp

>T150742 NZ_CP065022:791299-791853 [Sinorhizobium meliloti]
ATGAGGAAACACATTCCGCCCGCATCGCGACCCGATCCGGAACCGACGTCGCCGGTCGAGCCGATAACGCTCTGGCGCGC
CTTCGTTCCGCGCTGGGCACATATGCCGCTATCCGGCGCGGGTGCCGCTCGCTTCGGTGGCCGCTGGAACCCGATCGGCA
TGCCTGCGATTTATGCTGCGCGCGAGCTTTCCACTGCCTGGGCTGAATATAATCAGGGTTTCGTGCAGCATCCGGCGCTC
ATCGTGCAGCTCGAGTTGCGCGGGGCGAGGCTCGCGGACCTCACGGATGCCAGCGTTCTTCTGGAGCTTGGTGTGGATGA
GGCGATCCATCGCTGCGAATGGCGTGATGCGCTCGACAAAGGCGCGGTGCCGGAGACCCACAGGCTGCAGTCGGAGCTTC
TGGCGCGCGACTATCACGGGGTGATCTATCCATCCTTCATGTCGCCCGGCGGCACCTGCGTCGCGCTCTGGCGCTGGAAC
GGCGCGGAAGAACCGCGTCTCGACGTCATCGATCCCGATGGCCGGCTGCCGAAATCGCCCGCCTCATGGGTTTGA

Antitoxin


Download         Length: 65 a.a.        Molecular weight: 7097.98 Da        Isoelectric Point: 4.1759

>AT150742 WP_005142544.1 NZ_CP049171:c4088518-4088324 [Shigella sonnei]
MSTVLSPMVSEFETVEQENSYNEWLRAKVAASLADPRPAIPHDEVMAEMEQIIAQIAAATHRGE

Download         Length: 195 bp

>AT150742 NZ_CP065022:790921-791292 [Sinorhizobium meliloti]
ATGATGGCCGTTGATTTCCAGATACCTGCAGCCCGTTTCGGGGACGATCATTCCCCGTTTCTCTCGGCCCGCCTTGTCGC
CGACCGGTTGGGCGTCACGCTCGCCGAACTCGCCAAGCTGATCGGTGTCGCTCGCAATACGCTGACGGCGAAATCCGGCG
CCCGGAAGGTCGACAGCGCCTTGAGCAAGGTCGTCCGCATCCTCGCCATGGCTTCCGAAATGGCGGGCGACGAAGCCCGC
GCCGTCATCTGGTTCAAGCACCAGCCTATCCCCGGCTGGGCCGGCAAGACGGCGTTCGATCTGGTCGGCGAGGGCAAGGC
CGACAAGGTGCTCGCCTATCTCGAATCGGTACGTGCCGGCGTCTACGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A377EAU1

Antitoxin

Source ID Structure
AlphaFold DB A0A376K4R9

References