Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 2902467..2903085 Replicon chromosome
Accession NZ_CP049171
Organism Shigella sonnei strain 0401930105

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag G6O59_RS14415 Protein ID WP_001291435.1
Coordinates 2902467..2902685 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A0H8V4S8
Locus tag G6O59_RS14420 Protein ID WP_000344804.1
Coordinates 2902711..2903085 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6O59_RS14380 (2897759) 2897759..2898331 + 573 WP_000779812.1 YbaY family lipoprotein -
G6O59_RS14385 (2898362) 2898362..2898673 - 312 WP_000409911.1 MGMT family protein -
G6O59_RS14395 (2899052) 2899052..2899405 + 354 WP_000878140.1 DUF1428 domain-containing protein -
G6O59_RS14400 (2899447) 2899447..2900995 - 1549 Protein_2792 cyclic-guanylate-specific phosphodiesterase PdeB -
G6O59_RS14405 (2901159) 2901159..2901629 - 471 WP_000136192.1 YlaC family protein -
G6O59_RS14410 (2901745) 2901745..2902296 - 552 WP_000102564.1 maltose O-acetyltransferase -
G6O59_RS14415 (2902467) 2902467..2902685 - 219 WP_001291435.1 HHA domain-containing protein Toxin
G6O59_RS14420 (2902711) 2902711..2903085 - 375 WP_000344804.1 Hha toxicity modulator TomB Antitoxin
G6O59_RS14425 (2903631) 2903631..2906780 - 3150 WP_001132464.1 efflux RND transporter permease AcrB -
G6O59_RS14430 (2906803) 2906803..2907996 - 1194 WP_011310152.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T150733 WP_001291435.1 NZ_CP049171:c2902685-2902467 [Shigella sonnei]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T150733 NZ_CP065020:c3573355-3572951 [Sinorhizobium meliloti]
GTGATCTCCCATATTCTCGACACCAACGCCGTCATCGCTTTGATCGGGCGCAAATCGGATGCATTGGTCACCCGTGTACT
CCATAGCCCTCAGGGCATTATCGGGCTCCCGTCGGTCGTCGCGTATGAACTCTATTTTGGAGCGCAGAAAAGCGCGAAGG
CCCAACACAATCTCGAAACCCTGCGTTTGTTGATGGCGGATTTTCCGATCCTCGACTTCGACCGGAACGATGCCTTTGTC
GCAGGCGAGATCCGGGCCGCCCTTGCCGCGAAGGGTACGCCCATCGGACCTTATGACGTGCTGATTGCGGGACAGGCCAA
AGCCCGTGGATTGACGCTCGTCACCAACAATGTCGGCGAGTTCAATAGGGTTGAGAACCTGCGCGTGGAGGATTGGTCGC
TCTAG

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14615.43 Da        Isoelectric Point: 4.6232

>AT150733 WP_000344804.1 NZ_CP049171:c2903085-2902711 [Shigella sonnei]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIETFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT150733 NZ_CP065020:c3573612-3573352 [Sinorhizobium meliloti]
ATGCCCCATCTTGCACGGGTGTTCCAGTCCGGAAATTCGCAGGCCGTCCGCCTGCCTAAGGAATTCCGCTTCAACGTCGA
TCGCGTCGAAATCACGCAGGAAGGCGACGCGCTCATTCTCCGCCCGCACGTCGAGCAAGGCGAGCAGTGGTCATCGCTGA
AGGCGGCACTTGCCCGTGGCATGAGTGAAGACTTCATGATGTGCGGGCGCGAGCAGCCGGAACAGCAGGATCGGCCGGAA
CTCGACGCGGTATTTCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H8V4S8

References