Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 2176704..2177201 Replicon chromosome
Accession NZ_CP049171
Organism Shigella sonnei strain 0401930105

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag G6O59_RS10825 Protein ID WP_001173343.1
Coordinates 2177028..2177201 (+) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID L4JK92
Locus tag G6O59_RS10820 Protein ID WP_000398619.1
Coordinates 2176704..2177000 (+) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6O59_RS10800 (2173435) 2173435..2174154 - 720 WP_000611285.1 two-component system response regulator DcuR -
G6O59_RS10805 (2174151) 2174151..2175782 - 1632 WP_001216495.1 sensor histidine kinase -
G6O59_RS10810 (2175963) 2175963..2176193 + 231 WP_000371698.1 4Fe-4S mono-cluster protein YjdI -
G6O59_RS10815 (2176205) 2176205..2176477 + 273 WP_000405647.1 GNAT family N-acetyltransferase -
G6O59_RS10820 (2176704) 2176704..2177000 + 297 WP_000398619.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
G6O59_RS10825 (2177028) 2177028..2177201 + 174 WP_001173343.1 type V toxin-antitoxin system toxin GhoT Toxin
G6O59_RS10830 (2177320) 2177320..2178837 - 1518 Protein_2095 lysine--tRNA ligase -
G6O59_RS10835 (2179074) 2179074..2180531 - 1458 WP_000856831.1 dipeptide/tripeptide permease DtpC -
G6O59_RS10840 (2180590) 2180590..2180847 - 258 Protein_2097 lysine decarboxylase LdcC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T150730 WP_001173343.1 NZ_CP049171:2177028-2177201 [Shigella sonnei]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

>T150730 NZ_CP065020:2644772-2645176 [Sinorhizobium meliloti]
TTGAACGGGTATCTTCTCGATACGAACATCATCAGCGACATCATTCACAATCCGTTCGGACCGGCTGCGCAACGCATCGA
ACGGATCGGCCCGAAGGAGATTTACACCAGCATCGTCGTCGCGTCCGAGTTGCGGTATGGTTGCGCAAAAAAGGGATCGG
CGAAGTTGCTCGCCAAGGTCGAAAGCTTGCTGGAAATCGTCCCGGTGCTGCCATTGGATATTCCGGCCGACACCCGATAT
GGCAGCATTCGTGCGGAATTGGAGTCTCTGGGGCAGACCATCGGCTCCAACGATCTGTTGATTGCCGCGCATGCGTATGG
GCTGGACCTGACGCTGGTGACGGACAATATCCGTGAGTTCAGCCGCGTTCGTGGCCTTAGTCTGGAAAACTGGCTTGAGC
GATAG

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11467.97 Da        Isoelectric Point: 4.1705

>AT150730 WP_000398619.1 NZ_CP049171:2176704-2177000 [Shigella sonnei]
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLNIMTVDDYFRQFYK

Download         Length: 297 bp

>AT150730 NZ_CP065020:2644503-2644775 [Sinorhizobium meliloti]
ATGCCCGTCCCGTTGCCGTCATCGCGACCTAGAGAAGTAAAGCTGTTCCGCAATAACCGCAGCCAGGCAGTCCGTATTCC
TGCGGAGTTCGAGTTGCCTGGAGACCGTGTGTTGATCCGTCGCGAAGGAACGAGACTCATTATCGAACCGGTAGCCAGGC
CAGCAGATATCGTGGAGCTTCTCGCGGAGTGGAAGAAGGAAGCTCCCCTCGGACCTGAAGACCGGTTCCCGGATGTTGAG
GATATACCCGCCCGGCCGGAGAAAATCTTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QI41

Antitoxin

Source ID Structure
PDB 2LLZ
AlphaFold DB A0A7U9QBH6

References