Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 2226691..2227345 Replicon chromosome
Accession NZ_CP049169
Organism Shigella sonnei strain 19.1125.3493

Toxin (Protein)


Gene name cptA Uniprot ID S1EEB2
Locus tag G6O58_RS10990 Protein ID WP_000244777.1
Coordinates 2226938..2227345 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag G6O58_RS10985 Protein ID WP_000354046.1
Coordinates 2226691..2226957 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6O58_RS10960 (2221860) 2221860..2222603 + 744 WP_000951937.1 SDR family oxidoreductase -
G6O58_RS10965 (2222660) 2222660..2224093 - 1434 WP_005137189.1 6-phospho-beta-glucosidase BglA -
G6O58_RS10970 (2224138) 2224138..2224449 + 312 WP_001182954.1 N(4)-acetylcytidine aminohydrolase -
G6O58_RS10975 (2224613) 2224613..2225272 + 660 WP_000250274.1 hemolysin III family protein -
G6O58_RS10980 (2225468) 2225468..2226448 - 981 WP_000886060.1 tRNA-modifying protein YgfZ -
G6O58_RS10985 (2226691) 2226691..2226957 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
G6O58_RS10990 (2226938) 2226938..2227345 + 408 WP_000244777.1 protein YgfX Toxin
G6O58_RS10995 (2227385) 2227385..2227906 - 522 WP_001055874.1 flavodoxin FldB -
G6O58_RS11000 (2228018) 2228018..2228914 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
G6O58_RS11005 (2228939) 2228939..2229649 + 711 WP_000715206.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
G6O58_RS11010 (2229655) 2229655..2231388 + 1734 WP_000813167.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16031.96 Da        Isoelectric Point: 11.5202

>T150712 WP_000244777.1 NZ_CP049169:2226938-2227345 [Shigella sonnei]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

>T150712 NZ_CP064935:829846-830127 [Rhizobium phaseoli]
GTGATCAGGTCATTCAAGGACGCCAAAACCGAAGCCGTCGCGCGGGGCAAAGCACCAAAAGGATTTCCTTCTGACATCGT
GAGGTCTGCCATTCGGAAATTGACGATCCTGAACAGCGTTGCCGTGCTTGAGGACCTGCGTTCTCCTCCGGGAAATCGAT
TAGAAGCCCTTAAGGGCAATAGGGAAGGCCAGCATTCGATCCGGATCAATGATCAGTGGCGAATCTGTTTCGTATGGACA
GATGCCGGTATCGAAGACGTCGAAATAGTTGACTACCATTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT150712 WP_000354046.1 NZ_CP049169:2226691-2226957 [Shigella sonnei]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT150712 NZ_CP064935:830158-830457 [Rhizobium phaseoli]
ATGACCCATATACTTCCGCCGGTCCATCCGGGCGAAATTCTCCGCGAGGAATACCTACTTCCTCTGAACATGAGCGCCGG
CGCACTGGCGAAAAAGCTTAATGTTCCTCGCACGCGCATCGAACGTATAGCGGCGGAGCAAACACCGATTACGACGGATA
CCGCACTGCGCCTTGCAAAGTACTTCCGCACAACGCCGGAATTTTGGATGAACATGCAGACAAGCTTCAACCTCAAGACA
GAAGAAATGGCACTTCATAGCGAATTGGAGCTTATCCCGGAAATCGATAGAGCGGCATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LFV7

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References