Detailed information of TA system TA150710

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PsyrTA/-
• Location: 1583918..1585257
• Replicon: chromosome
• Accession: NZ_CP049169
• Organism: Shigella sonnei strain 19.1125.3493

Toxin (Protein)

• Gene name: PsyrT
• Uniprot ID: -
• Locus tag: G6O58_RS07660
• Protein ID: WP_001119379.1
• Coordinates: 1583918..1584055 (+)
• Length: 46 a.a.

Antitoxin (Protein)

• Gene name: PsyrA
• Uniprot ID: A0A656BP16
• Locus tag: G6O58_RS07665
• Protein ID: WP_001053680.1
• Coordinates: 1584055..1585257 (+)
• Length: 401 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
G6O58_RS07640 (1579296)	1579296..1579823	+	528	WP_000108330.1	gluconokinase	-
G6O58_RS07645 (1579827)	1579827..1581167	+	1341	WP_000210099.1	gluconate transporter	-
G6O58_RS07650 (1581308)	1581308..1583119	+	1812	WP_005140413.1	helicase-related protein	-
G6O58_RS07655 (1583148)	1583148..1583845	+	698	WP_094096600.1	IS1-like element IS1A family transposase	-
G6O58_RS07660 (1583918)	1583918..1584055	+	138	WP_001119379.1	hypothetical protein	Toxin
G6O58_RS07665 (1584055)	1584055..1585257	+	1203	WP_001053680.1	DNA-processing protein DprA	Antitoxin
G6O58_RS07670 (1585303)	1585303..1585896	-	594	WP_000991414.1	NAAT family transporter YhgN	-
G6O58_RS07675 (1586088)	1586088..1587191	+	1104	WP_000799956.1	aspartate-semialdehyde dehydrogenase	-
G6O58_RS07680 (1587265)	1587265..1587306	+	42	WP_211180509.1	protein YhgO	-
G6O58_RS07685 (1587464)	1587464..1589650	+	2187	WP_001283723.1	1,4-alpha-glucan branching enzyme	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Phosphoribosyltransferase domain (6-34)

Antitoxin

• DNA recombination-mediator protein A (89-292)

Sequences

Toxin

Protein

• Length: 46 a.a.
• Molecular weight: 4683.50 Da
• Isoelectric Point: 4.3115

>T150710 WP_001119379.1 NZ_CP049169:1583918-1584055 [Shigella sonnei]
MPGPALLVDDIVDSAWTLTVLTALLRQAGCPTVYPLALASTSVKN

Nucleotide

• Length: 138 bp

>T150710 NZ_CP064935:c102189-101935 [Rhizobium phaseoli]
ATGAACAGCAAGCAGAGAAAGACTCTCGCGGCGGTCTTCAAGGACCCGGTCTCGGGAACCATCGAATGGGCCGCTATAGA
GAATCTGCTTGTGGCTGCCGGGGCCGACCTCATTGAGGGGAACGGTTCCCGCGTTAAGTTTGAAAAGGACGGGATCATTG
CGAGCTTCCATAGACCACATCCGGCCAAGGAAGCAAAGCGTTATCAGGTGCGCGATGCTCGCGAGTTCCTGATGCAGATT
GGAGGAACGCCATGA

Antitoxin

Protein

• Length: 401 a.a.
• Molecular weight: 43812.21 Da
• Isoelectric Point: 6.6429

>AT150710 WP_001053680.1 NZ_CP049169:1584055-1585257 [Shigella sonnei]
MNLSANAQATLLLTSDFSRAAASEYKPLSNSEWGKFALWLKHQRISPAELLVPQPQEKLTGWSDPRISQERILGLLARGH
SLALAVDKWQRAGLWILTRGDADYPVRLKNRLRTDAPPVLFGCGNKALLQAEGMAIVGSRDAPTDDLRYTQQLAAKLAQQ
GICVISGGARGIDECAMASALEAGGTAVGVLADSLLKTSTLVKWREGLIAGNLVLISPFYPEVRFTVGNAMARNKYIYCL
AESAMVVRAGMTGGTITGAMEALKHQWLPVQVKPNQDMQSANSRLVENGASWSAEQAENVTIRLPDVPGLMYDRALRNAQ
PELFSLHEDDANYAVMPAYTPVDFYQLFVAELAILAKESISIERLASCTGLTIEQISVWLNRAEEEGRVIRLGEGHYQFR

Nucleotide

• Length: 1203 bp

>AT150710 NZ_CP064935:c101938-101582 [Rhizobium phaseoli]
ATGAACATCATGACCTACAACGGATATCACGCTCGCATCGAATTCGACGCTGAGGACGATGTGTTTTTCGGCAGGATTGC
AGGTATCTCCGATGTAATCGGCTTTCACGGTGACAGTGTCGCTGAACTCAAGAAAGCCTTCCATGAGGCAGTCGATGACT
ACCTGGAGACCTGCAGGAAAATCGGCAAAGAGCCTCAGCGACCCTATTCTGGGAAGATGATGTTTCGTGTCGCTCCCGAA
GTCCATCGCCGAGCAGCTCTTGCTGCTGAGCTTTCGGGAAAGAGTCTGAACCAGTGGGCAGAAGAGGTGCTGAAAGAGGC
CGCCGACCATTTTGCCGAGGCGCGCTTGCCGGCGTAG

Structures

Antitoxin

• AlphaFold DB: A0A656BP16