Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4204874..4205492 Replicon chromosome
Accession NZ_CP049167
Organism Shigella sonnei strain 09163633

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag G6O57_RS21260 Protein ID WP_001291435.1
Coordinates 4205274..4205492 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A0H8V4S8
Locus tag G6O57_RS21255 Protein ID WP_000344804.1
Coordinates 4204874..4205248 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6O57_RS21245 (4199963) 4199963..4201156 + 1194 WP_011310152.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
G6O57_RS21250 (4201179) 4201179..4204328 + 3150 WP_001132464.1 efflux RND transporter permease AcrB -
G6O57_RS21255 (4204874) 4204874..4205248 + 375 WP_000344804.1 Hha toxicity modulator TomB Antitoxin
G6O57_RS21260 (4205274) 4205274..4205492 + 219 WP_001291435.1 HHA domain-containing protein Toxin
G6O57_RS21265 (4205663) 4205663..4206214 + 552 WP_000102564.1 maltose O-acetyltransferase -
G6O57_RS21270 (4206330) 4206330..4206800 + 471 WP_052942789.1 YlaC family protein -
G6O57_RS21275 (4206964) 4206964..4208512 + 1549 Protein_4149 cyclic-guanylate-specific phosphodiesterase PdeB -
G6O57_RS21280 (4208554) 4208554..4208907 - 354 WP_000878140.1 DUF1428 domain-containing protein -
G6O57_RS21290 (4209286) 4209286..4209597 + 312 WP_000409911.1 MGMT family protein -
G6O57_RS21295 (4209628) 4209628..4210200 - 573 WP_000779812.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T150700 WP_001291435.1 NZ_CP049167:4205274-4205492 [Shigella sonnei]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T150700 NZ_CP064923:4196821-4197084 [Acaryochloris marina S15]
ATGAGTAGTCGCAAATTGGCCTGGACAGATGCTGCCTGGAATGACTATCTCTACTGGCAAGGACAGGATAAAAAAACGCT
GAAGCGGATCAATAAGCTCATTCAGGCTACGAACAATCAGCCATTTGAAGGCATTGGTAAACCTGAGGCTTTACGAGAAA
ATCTATCGGGATTTTGGTCTCGACGCATAGATGAGACCCATCGATTAGTCTATGCCATTGATGATCACTATCTGACAATT
ATTGCCTGTCGGTATCATTATTAG

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14615.43 Da        Isoelectric Point: 4.6232

>AT150700 WP_000344804.1 NZ_CP049167:4204874-4205248 [Shigella sonnei]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIETFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT150700 NZ_CP064923:4196574-4196828 [Acaryochloris marina S15]
ATGAACATCATTTCCTTCAGTGAAGCCCGCAGCAAACTGAAAGCTGTCTTCGATCGAGTCGTTGATGATGCCGACTACAC
GATCATCACTCGACGAGATGCTGATGATGCAGTGTTGATGTCTCTGGAGTCTTTTAATAGCTTGCTAGAAACCGTTCATT
TGTTAAAGTCACCCGCCAATGCAGCTCACCTAGAACAATCCATTGCCCAATATCGACAGGGACAAGTGACTGAGCAAGAC
CTCTTGGATGAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H8V4S8

References