Detailed information of TA system TA150691

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): paaR-paaA-parE/-
• Location: 2992882..2993366
• Replicon: chromosome
• Accession: NZ_CP049167
• Organism: Shigella sonnei strain 09163633

Toxin (Protein)

• Gene name: parE_1
• Uniprot ID: A0A377EAU1
• Locus tag: G6O57_RS15065
• Protein ID: WP_014334020.1
• Coordinates: 2992882..2993172 (-)
• Length: 97 a.a.

Antitoxin (Protein)

• Gene name: paaA
• Uniprot ID: A0A376K4R9
• Locus tag: G6O57_RS15070
• Protein ID: WP_005142544.1
• Coordinates: 2993172..2993366 (-)
• Length: 65 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
G6O57_RS15035 (2988082)	2988082..2989158	-	1077	Protein_2925	molybdopterin dinucleotide binding domain-containing protein	-
G6O57_RS15040 (2989216)	2989216..2989913	+	698	WP_094096600.1	IS1-like element IS1A family transposase	-
G6O57_RS15045 (2989907)	2989907..2990695	-	789	Protein_2927	Rha family transcriptional regulator	-
G6O57_RS15050 (2991228)	2991228..2991925	+	698	WP_094096600.1	IS1-like element IS1A family transposase	-
G6O57_RS15055 (2992073)	2992073..2992438	-	366	WP_024174355.1	hypothetical protein	-
G6O57_RS15060 (2992450)	2992450..2992602	-	153	WP_000379558.1	DUF1391 family protein	-
G6O57_RS15065 (2992882)	2992882..2993172	-	291	WP_014334020.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
G6O57_RS15070 (2993172)	2993172..2993366	-	195	WP_005142544.1	hypothetical protein	Antitoxin
G6O57_RS15075 (2993386)	2993386..2993916	-	531	WP_252900167.1	helix-turn-helix domain-containing protein	-
G6O57_RS15080 (2993998)	2993998..2994261	+	264	WP_001048456.1	helix-turn-helix transcriptional regulator	-
G6O57_RS15085 (2994258)	2994258..2994683	+	426	WP_000693826.1	toxin YdaT family protein	-
G6O57_RS15090 (2994755)	2994755..2995819	+	1065	WP_001262380.1	hypothetical protein	-
G6O57_RS15095 (2995826)	2995826..2996572	+	747	WP_000788740.1	ATP-binding protein	-
G6O57_RS15100 (2996594)	2996594..2997319	+	726	WP_000450631.1	DUF1627 domain-containing protein	-
G6O57_RS15105 (2997335)	2997335..2997757	+	423	WP_001151171.1	DUF977 family protein	-
G6O57_RS15110 (2997815)	2997815..2998171	+	357	WP_005140877.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2975483..3002168	26685

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-91)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 97 a.a.
• Molecular weight: 11062.93 Da
• Isoelectric Point: 10.2013

>T150691 WP_014334020.1 NZ_CP049167:c2993172-2992882 [Shigella sonnei]
MLPVLWLPSARDDLRQIVAYIAKENPAAARRMKIRIETSVLPLTEHPYLYPPSERVLGLREIVTHPNYIILYRVTASSIE
VVNIVHSRRQYPGKNS

Nucleotide

• Length: 291 bp

>T150691 NZ_CP064923:c1631743-1631534 [Acaryochloris marina S15]
GTGCAAGCACGTATTGACCGTATCGAGATTGGCAACTTCGGCGATGTTGCCGGGGTTAGCGAGCTTCGCATTCATTATGG
TCCGGGTTACAGAGTTTACTTTGTACAACGTGGTTCAGTTGTTGTCATATTGCTGTCTGGTGGCGATAAAAGCTCCCAAA
ATGCTGACATTAAAAGGGCCAAGGAAATTGCTAAACCGTTGGAGGATTGA

Antitoxin

Protein

• Length: 65 a.a.
• Molecular weight: 7097.98 Da
• Isoelectric Point: 4.1759

>AT150691 WP_005142544.1 NZ_CP049167:c2993366-2993172 [Shigella sonnei]
MSTVLSPMVSEFETVEQENSYNEWLRAKVAASLADPRPAIPHDEVMAEMEQIIAQIAAATHRGE

Nucleotide

• Length: 195 bp

>AT150691 NZ_CP064923:c1631533-1631237 [Acaryochloris marina S15]
ATGATGTCCATAAGCACAACTCGCTGGGATTCAGCCGCGCATCTCAAAACAGACGAAGATATTCAGCTATACCTAGAGGC
ATGTGTTGAAGAAGCAGAAGATGATCCTGCTTTAATTATTCATGCTCTAGGAGTTGTCGCTAGGGCTAAAAATATGAGTC
AACTCTCCCGAGAAACAGGTTTGAGCAGAGAAGGGCTGTATAAAGCGCTATCAGTTGATGGCAACCCCACTTTTGCGATA
GTCGCAAAAGTTACTAAAGCCCTCGGATTCAAGCTAACCATTCAGCCAACGGTTTAG

Structures

Toxin

• AlphaFold DB: A0A377EAU1

Antitoxin

• AlphaFold DB: A0A376K4R9