Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 100621..101118 Replicon chromosome
Accession NZ_CP049167
Organism Shigella sonnei strain 09163633

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag G6O57_RS00530 Protein ID WP_001173343.1
Coordinates 100621..100794 (-) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID L4JK92
Locus tag G6O57_RS00535 Protein ID WP_000398619.1
Coordinates 100822..101118 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6O57_RS00510 (95773) 95773..96929 + 1157 WP_087879933.1 IS3-like element IS600 family transposase -
G6O57_RS00515 (96975) 96975..97232 + 258 Protein_98 lysine decarboxylase LdcC -
G6O57_RS00520 (97291) 97291..98748 + 1458 WP_000856831.1 dipeptide/tripeptide permease DtpC -
G6O57_RS00525 (98985) 98985..100502 + 1518 WP_001295086.1 lysine--tRNA ligase -
G6O57_RS00530 (100621) 100621..100794 - 174 WP_001173343.1 type V toxin-antitoxin system toxin GhoT Toxin
G6O57_RS00535 (100822) 100822..101118 - 297 WP_000398619.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
G6O57_RS00540 (101345) 101345..101617 - 273 WP_000405647.1 GNAT family N-acetyltransferase -
G6O57_RS00545 (101629) 101629..101859 - 231 WP_000371698.1 4Fe-4S mono-cluster protein YjdI -
G6O57_RS00550 (102040) 102040..103671 + 1632 WP_001216495.1 sensor histidine kinase -
G6O57_RS00555 (103668) 103668..104387 + 720 WP_000611285.1 two-component system response regulator DcuR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T150685 WP_001173343.1 NZ_CP049167:c100794-100621 [Shigella sonnei]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

>T150685 NZ_CP064908:c2859143-2858799 [Synechococcus sp. CBW1107]
GTGAGCGCCCTCGAGAGGTACACGGTGGTGCGGGTGCCGTTCCCATTCACGGATCGGCAGGACCAGAAGCAGCGGCCGGC
GTTGGTGCTCTCACAGCCTGGCTTCCAGCGAGGCTGTGGCCATCTGCTGCTGGCGATGATCACATCAGCGCGGCAATCCT
CGTGGCCCCTCGATTGGCCCCTTGAAGATCTCAAGGCCGCAGGCCTGCCCCAACCCTGCCTGGTGCGCTTCAAGCTGTTC
ACCCTTGATGAGCGATTGGTGTTGGGGGGCCTGGGCGCTCTGGCCGCCGCTGATTGCGCCGGTGTGTCGGCCCAGCTGGG
CAAGCTGCTGCCCTCCAGGACCTGA

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11467.97 Da        Isoelectric Point: 4.1705

>AT150685 WP_000398619.1 NZ_CP049167:c101118-100822 [Shigella sonnei]
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLNIMTVDDYFRQFYK

Download         Length: 297 bp

>AT150685 NZ_CP064908:c2859364-2859140 [Synechococcus sp. CBW1107]
ATGGACGTCGCCACACTCACCGCCAAGGGGCAGGTCACGGTGCCGAAGGCCGTGCGTGAGGCCCTGGGATTGCGACAGGG
CGACCAGCTCAGTTGGGAGCTGGAGGATGGCTCGGTGCGGGTGCGAGCGGTGGCGCCATTGGATCTGGCCTATCTCCAGG
GGCTGGACAGCAGCCTGAGCGATTGGAGCAGCCCGGCGGATGAGGAGGCGTTCCGCGATCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QI41

Antitoxin

Source ID Structure
PDB 2LLZ
AlphaFold DB A0A7U9QBH6

References