Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4325224..4325878 Replicon chromosome
Accession NZ_CP049165
Organism Shigella sonnei strain 0401952027

Toxin (Protein)


Gene name cptA Uniprot ID S1EEB2
Locus tag G6O56_RS21850 Protein ID WP_000244777.1
Coordinates 4325471..4325878 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag G6O56_RS21845 Protein ID WP_000354046.1
Coordinates 4325224..4325490 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6O56_RS21820 (4320393) 4320393..4321136 + 744 WP_000951937.1 SDR family oxidoreductase -
G6O56_RS21825 (4321193) 4321193..4322626 - 1434 WP_005137189.1 6-phospho-beta-glucosidase BglA -
G6O56_RS21830 (4322671) 4322671..4322982 + 312 WP_001182954.1 N(4)-acetylcytidine aminohydrolase -
G6O56_RS21835 (4323146) 4323146..4323805 + 660 WP_000250274.1 hemolysin III family protein -
G6O56_RS21840 (4324001) 4324001..4324981 - 981 WP_000886060.1 tRNA-modifying protein YgfZ -
G6O56_RS21845 (4325224) 4325224..4325490 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
G6O56_RS21850 (4325471) 4325471..4325878 + 408 WP_000244777.1 protein YgfX Toxin
G6O56_RS21855 (4325918) 4325918..4326439 - 522 WP_001055874.1 flavodoxin FldB -
G6O56_RS21860 (4326551) 4326551..4327447 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
G6O56_RS21865 (4327472) 4327472..4328182 + 711 WP_000715206.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
G6O56_RS21870 (4328188) 4328188..4329921 + 1734 WP_000813167.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16031.96 Da        Isoelectric Point: 11.5202

>T150679 WP_000244777.1 NZ_CP049165:4325471-4325878 [Shigella sonnei]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

>T150679 NZ_CP064879:7696666-7697109 [Tolypothrix sp. PCC 7601]
ATGAAAAATATAGATACTGTAATTGTTACGACTCGGTTAGAATTCATTGCTCGTTATCTTGACAATCTGAAAAGATTCGA
GGCAATTACTTGGGATGATTATCTCAATAATATTGATAATCAATTAATTACAGAAAGACTGCTACAATTAATGGCTCAAG
CTGCGATAGATATTAACGATCATATCTTGTCAAAGCTAAATCCAGGAAATTCAAATACTAACTTTGAAGCTTTTATTGAG
CTTGGTAATTATGGTGTGATTACTCCCGAACTAGCAAAACAATTGGCACCATCATCTGGATTAAGAAATCGCCTAGTTCA
TGAATATGACGATATAGATCCGCAGCAAGTTTTTAGGGCAATTAGTTTCGCTTTACAGCAATATCCACTGTATGTCAGAC
AAGTCAACTCATATTTAATTTCTTTGAGTGAAGAGAATGGCTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT150679 WP_000354046.1 NZ_CP049165:4325224-4325490 [Shigella sonnei]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT150679 NZ_CP064879:7696217-7696669 [Tolypothrix sp. PCC 7601]
ATGCAAAACCACACTCCAACAATTACAGAACTTCAAGAACTTGCCTTACAACTTCCTGAAAAAATCCCTTACTTAAAAAT
GTTAGTGCTATTTGGTTCTAGAGCTACTGGTAATGCAAACGCAAAAAGTGACTGGGATTTTGCAGTTTTGTGTGATGAAG
AACAGCGTGAAGCTTACATAAAAAATAATATTTCAGGTTTGTTTGAATTACCTATGTTGATTGGCGAAGTATTAAAAATC
AATTCTGACAAAATCGACATTGTAGAACTTAATCACTGTTCTGAATTAATAGCACATTTTGTTGCTCGCGATGGCAAAGT
TTTGTATGAATCTGAAGCTGAAGAATTTGAAAAATTTAAACAAAAAGTATTACTAAGCAAATCAGAGCTTAAAAAAATTG
AACATATTAAACGACAAAACATTGAGCAGTTTCTCCAAAGATGGGGTGTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LFV7

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References