Detailed information of TA system TA150677

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PsyrTA/-
• Location: 3682393..3683732
• Replicon: chromosome
• Accession: NZ_CP049165
• Organism: Shigella sonnei strain 0401952027

Toxin (Protein)

• Gene name: PsyrT
• Uniprot ID: -
• Locus tag: G6O56_RS18520
• Protein ID: WP_001119379.1
• Coordinates: 3682393..3682530 (+)
• Length: 46 a.a.

Antitoxin (Protein)

• Gene name: PsyrA
• Uniprot ID: A0A656BP16
• Locus tag: G6O56_RS18525
• Protein ID: WP_001053680.1
• Coordinates: 3682530..3683732 (+)
• Length: 401 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
G6O56_RS18500 (3677771)	3677771..3678298	+	528	WP_000108330.1	gluconokinase	-
G6O56_RS18505 (3678302)	3678302..3679642	+	1341	WP_000210099.1	gluconate transporter	-
G6O56_RS18510 (3679783)	3679783..3681594	+	1812	WP_005140413.1	helicase-related protein	-
G6O56_RS18515 (3681623)	3681623..3682320	+	698	WP_094096600.1	IS1-like element IS1A family transposase	-
G6O56_RS18520 (3682393)	3682393..3682530	+	138	WP_001119379.1	hypothetical protein	Toxin
G6O56_RS18525 (3682530)	3682530..3683732	+	1203	WP_001053680.1	DNA-processing protein DprA	Antitoxin
G6O56_RS18530 (3683778)	3683778..3684371	-	594	WP_000991414.1	NAAT family transporter YhgN	-
G6O56_RS18535 (3684563)	3684563..3685666	+	1104	WP_000799956.1	aspartate-semialdehyde dehydrogenase	-
G6O56_RS18540 (3685740)	3685740..3685781	+	42	WP_211180509.1	protein YhgO	-
G6O56_RS18545 (3685939)	3685939..3688125	+	2187	WP_001283723.1	1,4-alpha-glucan branching enzyme	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Phosphoribosyltransferase domain (6-34)

Antitoxin

• DNA recombination-mediator protein A (89-292)

Sequences

Toxin

Protein

• Length: 46 a.a.
• Molecular weight: 4683.50 Da
• Isoelectric Point: 4.3115

>T150677 WP_001119379.1 NZ_CP049165:3682393-3682530 [Shigella sonnei]
MPGPALLVDDIVDSAWTLTVLTALLRQAGCPTVYPLALASTSVKN

Nucleotide

• Length: 138 bp

>T150677 NZ_CP064879:723165-723458 [Tolypothrix sp. PCC 7601]
ATGATAGTATCATTTAAGAACAAAGCAACTGAAGACATTTTTGATGGTAATGACTCAAAGGAAGCCCGAAAACAGTGTCC
CATAAATTGTTGGGGAGTTGCACAGAGAAAATTAGATCAACTCAATGCAGCGTTCTCTTTGGATGATATGAAAGTTCCTC
CAGGTAATAGGTTAGAAGCTTTAAAAGGTGACCGCAAGGGTCAGCATAGCATTCGGATTAATGACCAATACCGGATTTGC
TTTACATGGATACCTGAAGGAGTATCAGAAGTTGAAATAGTAGACTACCATTAG

Antitoxin

Protein

• Length: 401 a.a.
• Molecular weight: 43812.21 Da
• Isoelectric Point: 6.6429

>AT150677 WP_001053680.1 NZ_CP049165:3682530-3683732 [Shigella sonnei]
MNLSANAQATLLLTSDFSRAAASEYKPLSNSEWGKFALWLKHQRISPAELLVPQPQEKLTGWSDPRISQERILGLLARGH
SLALAVDKWQRAGLWILTRGDADYPVRLKNRLRTDAPPVLFGCGNKALLQAEGMAIVGSRDAPTDDLRYTQQLAAKLAQQ
GICVISGGARGIDECAMASALEAGGTAVGVLADSLLKTSTLVKWREGLIAGNLVLISPFYPEVRFTVGNAMARNKYIYCL
AESAMVVRAGMTGGTITGAMEALKHQWLPVQVKPNQDMQSANSRLVENGASWSAEQAENVTIRLPDVPGLMYDRALRNAQ
PELFSLHEDDANYAVMPAYTPVDFYQLFVAELAILAKESISIERLASCTGLTIEQISVWLNRAEEEGRVIRLGEGHYQFR

Nucleotide

• Length: 1203 bp

>AT150677 NZ_CP064879:723472-723786 [Tolypothrix sp. PCC 7601]
ATGAGAGTTCCAAAGCATAGATCCCCCTCACATCCTGGGGAAATATTATTGAAAGATTTCTTAGAAGAAATGGGAATATC
ACAACGAGAACTTGCAGATGCAATACATGTTCCTTATCAGCGAATTAACGAGATTGTAAATCAAAAGCGGGGTATTACAC
CTAGTACAGCATTACGATTAGCTAAATTTTTTGGGAATAGTTCAGAGTTTTGGTTAAACCTCCAACAAAATTGGGAACTC
TACCATGTTTTGTTAGCAGAAGAAGCAGAATTAAAAAATATTAAACAGTTCAAAAGTTCTGAAGCAACGGCTTGA

Structures

Antitoxin

• AlphaFold DB: A0A656BP16