Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 2234546..2235164 Replicon chromosome
Accession NZ_CP049165
Organism Shigella sonnei strain 0401952027

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag G6O56_RS11490 Protein ID WP_001291435.1
Coordinates 2234946..2235164 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A0H8V4S8
Locus tag G6O56_RS11485 Protein ID WP_000344804.1
Coordinates 2234546..2234920 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6O56_RS11475 (2229635) 2229635..2230828 + 1194 WP_011310152.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
G6O56_RS11480 (2230851) 2230851..2234000 + 3150 WP_001132464.1 efflux RND transporter permease AcrB -
G6O56_RS11485 (2234546) 2234546..2234920 + 375 WP_000344804.1 Hha toxicity modulator TomB Antitoxin
G6O56_RS11490 (2234946) 2234946..2235164 + 219 WP_001291435.1 HHA domain-containing protein Toxin
G6O56_RS11495 (2235335) 2235335..2235886 + 552 WP_000102564.1 maltose O-acetyltransferase -
G6O56_RS11500 (2236002) 2236002..2236472 + 471 WP_000136192.1 YlaC family protein -
G6O56_RS11505 (2236636) 2236636..2238184 + 1549 Protein_2251 cyclic-guanylate-specific phosphodiesterase PdeB -
G6O56_RS11510 (2238226) 2238226..2238579 - 354 WP_000878140.1 DUF1428 domain-containing protein -
G6O56_RS11520 (2238958) 2238958..2239269 + 312 WP_000409911.1 MGMT family protein -
G6O56_RS11525 (2239300) 2239300..2239872 - 573 WP_000779812.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T150673 WP_001291435.1 NZ_CP049165:2234946-2235164 [Shigella sonnei]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T150673 NZ_CP064872:2850561-2850776 [Pantoea sp. SM3640]
ATGAACAAAACCCTGACTAAAACCGATTATTTGATGCGACTGCGGCGTTGCCGCTCTCTGGATACCCTGGAAAGGGTCAT
TGAAAAAAATAAGTATGAATTACCCGAGGATGAATTAGCGGTATTTTACTCTGCAGCTGACCATCGCCTGGCGGAACTGA
CGATGAACAAGCTTTATGATAAAGTCCCAGGTTCAGTATGGAAATTTGTCCGCTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14615.43 Da        Isoelectric Point: 4.6232

>AT150673 WP_000344804.1 NZ_CP049165:2234546-2234920 [Shigella sonnei]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIETFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT150673 NZ_CP064872:2850159-2850536 [Pantoea sp. SM3640]
ATGGACGAATACTCACCGAAACGGCATGATATTGCCCAGCTTAAATATCTGTGTGAGAGCCTGTTTGACGACAGCATGGC
AACATTAACCGACAGCCATCACGGCTGGGTGAACGACCCCACTTCTGAAAGCAATCTGCAGCTTAACGATTTGATTGAAC
ACATTGCCTCTTTCACCATGAATTACAAAATTAAGCACGTTGAAGATGAAGCGCTGATTTCGCAAATCGATGAATATCTT
GATGATACTTTTATGCTCTTCAGCAACTATGGTATCAATAGTCCGGATCTTCAACGGTGGCAACGTTCAGCAAAACGCTT
ATTTAATCTGTTCACTGAAGAGTGCGCTTTTCTCCAGCAACCAAGCCATTCATTATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H8V4S8

References