Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PfiT-PfiA/ParE(toxin)
Location 4731393..4732001 Replicon chromosome
Accession NZ_CP049161
Organism Pseudomonas aeruginosa strain MS14403

Toxin (Protein)


Gene name PfiT Uniprot ID A0A444LUU5
Locus tag WPAWT_RS21860 Protein ID WP_019486378.1
Coordinates 4731393..4731740 (-) Length 116 a.a.

Antitoxin (Protein)


Gene name PfiA Uniprot ID A0A0B0C355
Locus tag WPAWT_RS21865 Protein ID WP_003114155.1
Coordinates 4731750..4732001 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
WPAWT_RS21830 4726752..4727024 + 273 WP_003134390.1 cysteine-rich CWC family protein -
WPAWT_RS21835 4727024..4727716 + 693 WP_003085458.1 16S rRNA pseudouridine(516) synthase -
WPAWT_RS21840 4727852..4728895 + 1044 WP_003134392.1 L,D-transpeptidase -
WPAWT_RS21845 4728975..4729712 + 738 WP_003085453.1 murein L,D-transpeptidase catalytic domain family protein -
WPAWT_RS21850 4730164..4731066 + 903 WP_003085447.1 (R)-3-hydroxydecanoyl-ACP:CoA transacylase -
WPAWT_RS21860 4731393..4731740 - 348 WP_019486378.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
WPAWT_RS21865 4731750..4732001 - 252 WP_003114155.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
WPAWT_RS21870 4732215..4733198 - 984 WP_033942044.1 tyrosine-type recombinase/integrase -
WPAWT_RS21875 4733198..4734490 - 1293 WP_003454977.1 hypothetical protein -
WPAWT_RS21880 4735117..4735506 - 390 WP_033942042.1 hypothetical protein -
WPAWT_RS21885 4735499..4735714 - 216 WP_033942041.1 hypothetical protein -
WPAWT_RS21890 4735737..4735952 - 216 WP_003146175.1 hypothetical protein -
WPAWT_RS21895 4736070..4736339 + 270 WP_033942040.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-100)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 12956.72 Da        Isoelectric Point: 4.4212

>T150661 WP_019486378.1 NZ_CP049161:c4731740-4731393 [Pseudomonas aeruginosa]
MSPVVIRFTDTAEQSIEDQVHHLAPFQGEQAALQSVLSLLDEIEEKISLAPKGYPVSQQASLLGVLSYRELNTGPYRVFY
EFHEEQGEAAVILVLRQKQSVEQQLIRYCLVGPIE

Download         Length: 348 bp

>T150661 NZ_CP064871:390138-390272 [Xanthomonas oryzae pv. oryzicola]
ATGAAGCGTGCAATTGTGCTGCTGGTGCTGTCCATGTTGTCGGTCGGTCTGCTGTCGGGCTGCAACACCGTCGCAGGTGC
CGGCAAGGACGTGAAGGGCGCCGGCGAGAAGGTGGAAGACGCAGCGCGTAAGTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9442.79 Da        Isoelectric Point: 9.4808

>AT150661 WP_003114155.1 NZ_CP049161:c4732001-4731750 [Pseudomonas aeruginosa]
MRVETISYLKRHAADLDLSEPMVVTQNGVPAYVVESYAERKQRDEAIALVKLLAIGSRQYAEGKHRSVDDLKARLSRRFA
QPE

Download         Length: 252 bp

>AT150661 NZ_CP064871:389911-390063 [Xanthomonas oryzae pv. oryzicola]
ATGAAGCGACTGCTGACACTGATGGTGCTGGGCCTGTTTTCGGCCGGCGTGATGACGGGCTGCAACACCGTGGCTGGCGC
TGGCAAGGACTTGCAGGGCGCGGGTGGGAAGGTCGAGAAAACGGCCGAAAAATGCAGCGATGGTAAGTGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A444LUU5

Antitoxin

Source ID Structure
AlphaFold DB A0A0B0C355

References