150658

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) vapBC/-
Location 3473398..3474619 Replicon chromosome
Accession NZ_CP049161
Organism Pseudomonas aeruginosa strain MS14403

Toxin (Protein)


Gene name vapC Uniprot ID A0A0H2Z8V4
Locus tag WPAWT_RS15840 Protein ID WP_003110488.1
Coordinates 3474041..3474619 (+) Length 193 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag WPAWT_RS15835 Protein ID WP_003088112.1
Coordinates 3473398..3473952 (+) Length 185 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
WPAWT_RS15810 3468966..3469517 + 552 WP_003139878.1 XRE family transcriptional regulator -
WPAWT_RS15815 3469514..3469912 - 399 WP_023089053.1 NADH-quinone oxidoreductase subunit A -
WPAWT_RS15820 3469925..3470248 - 324 WP_003102734.1 multidrug efflux SMR transporter -
WPAWT_RS15825 3470579..3471040 + 462 WP_003102736.1 (2Fe-2S)-binding protein -
WPAWT_RS15830 3471045..3473240 + 2196 WP_043232957.1 xanthine dehydrogenase family protein molybdopterin-binding subunit -
WPAWT_RS15835 3473398..3473952 + 555 WP_003088112.1 helix-turn-helix domain-containing protein Antitoxin
WPAWT_RS15840 3474041..3474619 + 579 WP_003110488.1 HD domain-containing protein Toxin
WPAWT_RS15845 3474729..3475916 - 1188 WP_003102741.1 HlyD family efflux transporter periplasmic adaptor subunit -
WPAWT_RS15850 3475906..3478077 - 2172 WP_003114950.1 type I secretion system permease/ATPase -
WPAWT_RS15855 3478067..3479344 - 1278 WP_003102743.1 TolC family protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(7-188)

Antitoxin

(14-62)


Sequences


Toxin        


Download         Length: 193 a.a.        Molecular weight: 21913.75 Da        Isoelectric Point: 5.3655

>T150658 WP_003110488.1 NZ_CP049161:3474041-3474619 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDTPLRDRLLALWDEYERGETAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAARRDA

Download         Length: 579 bp

>T150658 NZ_CP064868:955948-956319 [Mammaliicoccus sciuri]
ATGAGAAGAGGAGATGTATATCTCGCAGATCTTTCACCAGTTACAGGTTCTGAACAAGGGGGGACAAGACCAGTCGTTAT
TATCCAGAATGATACAGGTAATCGATACAGCCCGACTGTGATTGTTGCAGCAATTACTGGTAAGATAAATAAAGCCAAAA
TTCCCACTCATGTAGAAATTGAGGCAGCGAAATATAAATTAGACAGAGATTCCGTAATTTTGCTTGAACAAATCAGGACA
ATTGATAAAAAACGCTTAAAAGAAAAATTAACATATTTATCTGATGCAAAGATGAAAGAGGTTGATATCGCTATTGCCAT
CAGCCTCAATCTAACTTTGCAACAAAAATTTGATACATTAGGTAATACATAA

Antitoxin


Download         Length: 185 a.a.        Molecular weight: 20454.63 Da        Isoelectric Point: 8.1590

>AT150658 WP_003088112.1 NZ_CP049161:3473398-3473952 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Download         Length: 555 bp

>AT150658 NZ_CP064868:955780-955947 [Mammaliicoccus sciuri]
ATGACATCTTTAACGCAAAATCGTACACAAAGTTTAGAACAAACACTGAAAGAAGGCTATCGTTCAATGGCCGATTTAAA
TCTCTCCCTTGCATCTGAAGCATACTATTGTGAATGTGAAGCTTGTGATTCAAATGAATCGCATATAGCCTCTCAGCAAG
GTGAATAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A0H2Z8V4


Antitoxin

Source ID Structure

References