150656

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 141519..142024 Replicon chromosome
Accession NZ_CP049161
Organism Pseudomonas aeruginosa strain MS14403

Toxin (Protein)


Gene name parE Uniprot ID V6A7K8
Locus tag WPAWT_RS00645 Protein ID WP_003083773.1
Coordinates 141519..141800 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1C7BDS9
Locus tag WPAWT_RS00650 Protein ID WP_003083775.1
Coordinates 141797..142024 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
WPAWT_RS00620 136770..138119 + 1350 WP_124138723.1 C4-dicarboxylate transporter DctA -
WPAWT_RS00625 138168..138854 + 687 WP_003083762.1 FadR family transcriptional regulator -
WPAWT_RS00630 138955..139689 + 735 WP_070137480.1 GntR family transcriptional regulator -
WPAWT_RS00635 139893..140279 + 387 WP_014602345.1 aegerolysin family protein -
WPAWT_RS00640 140311..141219 - 909 WP_124138722.1 LysR family transcriptional regulator -
WPAWT_RS00645 141519..141800 - 282 WP_003083773.1 type II toxin-antitoxin system toxin ParE Toxin
WPAWT_RS00650 141797..142024 - 228 WP_003083775.1 CopG family ribbon-helix-helix protein Antitoxin
WPAWT_RS00655 142200..142820 - 621 WP_003101226.1 hypothetical protein -
WPAWT_RS00660 142921..143421 + 501 WP_003112629.1 LEA type 2 family protein -
WPAWT_RS00665 143494..143835 + 342 WP_003101229.1 alkylphosphonate utilization protein -
WPAWT_RS00670 143917..145344 - 1428 WP_031756584.1 GABA permease -
WPAWT_RS00675 145513..147006 - 1494 WP_019681361.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10462.19 Da        Isoelectric Point: 10.0435

>T150656 WP_003083773.1 NZ_CP049161:c141800-141519 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

>T150656 NZ_CP064860:c2510764-2510582 [Companilactobacillus futsaii]
ATGCCAATGACACAAAAGGAAATGGTAAAACTATTGAAAACTAATGGATGGGCAAAAACAATTGGAGGAAAAGGCTCCCA
TATTAAAATGTCCAAGTTAGGAAAGCGTCCCATCACAGTGCCACATGGAGAACTTAATAAGTTCACAGAACGTGCAATAA
AAAAGGAAGCTGGATTAAAATAG

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8556.58 Da        Isoelectric Point: 5.5740

>AT150656 WP_003083775.1 NZ_CP049161:c142024-141797 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ

Download         Length: 228 bp

>AT150656 NZ_CP064860:c2510552-2510097 [Companilactobacillus futsaii]
ATGTTAGTAAGTTATCCCGCTCTATTTTATTATGATCAATCTGAAAAGGTACCGTTCTTTATTACTTTTCCTGACTTTAC
TAATTCTGGGACTCAAGGAAATGACGTAACAGATGCAATGTCGATGGCAACAGATTGGTTAGGAATCAATGTTGCTGATT
ATCTTGAAAATAATCGTCCTTTACCAGCCCCTTCAACATTGGAGGAAATTTCGTTAGCAAAAAATAATCCATATCCTGAA
GATTTAAAGTATGATTCAAAGCGTTCTTTTAAATCGATGGTTCTAGTTGATTTAGATAGCTATTTAAAAGGTGATATTAA
AATTAAAAAGACAGTTTCTATACCAAAGTGGGCCGATCGGGCTGGTGCAGATTTGCATATTAATTATTCGGCGACACTCA
CTGAAGCGATAGCTCAAGCTAAAATGTTGCATGATTCTAAAATTATGAATAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6XRW

Antitoxin

Source ID Structure
AlphaFold DB A0A1C7BDS9

References