Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 161767..162350 Replicon plasmid pSBC1_2
Accession NZ_CP049158
Organism Caballeronia sp. SBC1

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag SBC1_RS27605 Protein ID WP_165102153.1
Coordinates 162096..162350 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag SBC1_RS27600 Protein ID WP_165102150.1
Coordinates 161767..162099 (-) Length 111 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SBC1_RS27575 157062..157862 - 801 WP_165097072.1 IS21-like element helper ATPase IstB -
SBC1_RS27580 157840..159327 - 1488 WP_165097075.1 IS21 family transposase -
SBC1_RS27585 159320..159718 - 399 WP_147408238.1 hypothetical protein -
SBC1_RS27590 159690..160190 - 501 WP_165097078.1 hypothetical protein -
SBC1_RS27595 160621..161652 + 1032 WP_165102147.1 site-specific tyrosine recombinase XerC -
SBC1_RS27600 161767..162099 - 333 WP_165102150.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
SBC1_RS27605 162096..162350 - 255 WP_165102153.1 type II toxin-antitoxin system HicA family toxin Toxin
SBC1_RS27610 163224..163478 + 255 Protein_136 RHS repeat-associated core domain-containing protein -
SBC1_RS27615 163485..163868 + 384 WP_165104849.1 toxin C-terminal domain-containing protein -
SBC1_RS27620 164309..164530 - 222 WP_165102130.1 type I toxin-antitoxin system SymE family toxin -
SBC1_RS27625 164635..165027 - 393 WP_165102134.1 helix-turn-helix domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - adeG / gnd 1..1826371 1826371


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(23-75)

Antitoxin

Uncharacterised protein family HicB

(54-104)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9433.94 Da        Isoelectric Point: 10.9436

>T150652 WP_165102153.1 NZ_CP049158:c162350-162096 [Caballeronia sp. SBC1]
MKRAHTKTLELIFARPVSANVRWADIEALFLELGATITEREGSRIAVVLFGQVQVYHRPHPRPTTDKGAIASVRKWLESN
GVKP

Download         Length: 255 bp

>T150652 NZ_CP064858:1675458-1675712 [Vibrio europaeus]
ATGACCTATAAACTCGACTTTAAAAAGAGCGCACTCAAAGAGTGGAAAAAGCTAATCGAGCGCTTAGGTAACCCACATGT
TCCTGCTTCAAAGCTTTCTGGAGCTGATAACATGTATAAAATTAAGTTGTGTCAATCGGGCTACCGTCTCGTCTACAAAG
TTCAAGACGATGTCATCATTGTAACCGTCTTAGCAGTCGGAAAACGCGAACGTAGCGATGTTTACCGTAAAGCCATGAAA
AGGTTAGATGATTGA

Antitoxin


Download         Length: 111 a.a.        Molecular weight: 12163.65 Da        Isoelectric Point: 4.5594

>AT150652 WP_165102150.1 NZ_CP049158:c162099-161767 [Caballeronia sp. SBC1]
MNILSIDNYRAVVTYDPDTDMLRGEFLGLNGGADFYASDIPTLKTEGAKSLAVFLDVCRENGIDPVRHFSGRFNARIDPE
LHARAVETAAAEGISLNQLIERAIEHEVRT

Download         Length: 333 bp

>AT150652 NZ_CP064858:1675220-1675468 [Vibrio europaeus]
ATGACCACTAGAATTTTAGCCGATGTTGCTGCAAGCATTACTGAGTTGAAAGCTAACCCTATGAAAGTTGCAGCTAGTGC
TTACGGCGAACCTGTTGCTGTATTAAACCGAAATGAGCCAGCATTTTATTGCGTACCTGCCGAAGCGTACGAAATGATGA
TGGATAGACTCGAAGATCTGGAACTACTCGCTATCGCTAAAGAGCGTGAATCTGAAGAGAGCATTTCGGTAAATATTGAT
GACCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References