Detailed information of TA system TA150651

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-StbC
• Location: 115827..116466
• Replicon: plasmid pSBC1_2
• Accession: NZ_CP049158
• Organism: Caballeronia sp. SBC1

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: SBC1_RS27390
• Protein ID: WP_165102035.1
• Coordinates: 115827..116243 (-)
• Length: 139 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: SBC1_RS27395
• Protein ID: WP_165102037.1
• Coordinates: 116230..116466 (-)
• Length: 79 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SBC1_RS27375	112134..112817	+	684	WP_165102030.1	hypothetical protein	-
SBC1_RS27380	112971..114011	-	1041	WP_165102031.1	FUSC family protein	-
SBC1_RS27385	114332..115780	+	1449	WP_165102033.1	NAD-dependent succinate-semialdehyde dehydrogenase	-
SBC1_RS27390	115827..116243	-	417	WP_165102035.1	type II toxin-antitoxin system VapC family toxin	Toxin
SBC1_RS27395	116230..116466	-	237	WP_165102037.1	DNA-binding protein	Antitoxin
SBC1_RS27400	116655..119372	-	2718	WP_165102039.1	aconitate hydratase AcnA	-
SBC1_RS27405	119445..120896	-	1452	WP_165102041.1	bifunctional 2-methylcitrate dehydratase/aconitate hydratase	-
SBC1_RS27410	120922..121458	-	537	WP_165102044.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	adeG / gnd	1..1826371	1826371

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-130)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 139 a.a.
• Molecular weight: 15448.82 Da
• Isoelectric Point: 7.3198

>T150651 WP_165102035.1 NZ_CP049158:c116243-115827 [Caballeronia sp. SBC1]
VYLIDTNVISEIRKGANANKGVRKLFKRIGKDEIRLHLSAVTMGELRRGTEAVRHRGDAPQAAMLEAWLGTILDDYAMDV
ISIDDDVAQLWGRLRVPNPENPIDKLIAATALMHDLTVVTRNTKDFEKTGVKLLNPFE

Nucleotide

• Length: 417 bp

>T150651 NZ_CP064858:c1460501-1460196 [Vibrio europaeus]
ATGCCGCAAAGACATTTCAAATTAAGTAAGTTAGCTCAGCGCCACTTAATAAAAGTCAAAGAATACACTTTAGACAACTA
CTCCGAGCTTCAATGGCAAAGATATAAAGATACCTTGCTATCAGGATTCCAACTGTTAGCCGAGAACCCCGACTTAGGTC
GCGATTGTAGCGAAATCTACCCACAAGGTTTCTATTTTCATATAGGGAAACATACCGCCTACTTCACCAAAGAAAACGGA
TTTATCTTGATCGTTGCGGTATTAAATCAATCCCTGTTGCCAGAGAAGCATTTGAAAAGAAGATAA

Antitoxin

Protein

• Length: 79 a.a.
• Molecular weight: 8509.58 Da
• Isoelectric Point: 5.6939

>AT150651 WP_165102037.1 NZ_CP049158:c116466-116230 [Caballeronia sp. SBC1]
MANLLVRGIDEALVQSLRERAAAHGRSAEAEHREILAQALSRPKKRSLAEVLASMPNVGEDADFERIQDTGGAPRVFD

Nucleotide

• Length: 237 bp

>AT150651 NZ_CP064858:c1460752-1460510 [Vibrio europaeus]
ATGAACACACTAACAGCCAACGATGCTAAACGAAACTTTGGAGAGCTGCTATTAAGTGCTCAACGTGAACCTGTAAAGAT
CAGCAAGAACAGTAAAGACGCTGTCATTGTTATGTCTATCAAAGACTACGAGGAACTAGAGAGCATGAAAGCTGAGTATC
TTAAGCATTGCTTTGAATCAGCGAAGAAAGACTTAGCGGAAGGTAATACTATCGACGGCGAAAGCTTTTTGAAGGAACTC
TAA