Detailed information of TA system TA150648

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN-MazE
• Location: 2489976..2490612
• Replicon: chromosome
• Accession: NZ_CP049156
• Organism: Caballeronia sp. SBC1

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: SBC1_RS10890
• Protein ID: WP_165093264.1
• Coordinates: 2490196..2490612 (+)
• Length: 139 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: SBC1_RS10885
• Protein ID: WP_165093262.1
• Coordinates: 2489976..2490209 (+)
• Length: 78 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SBC1_RS10865	2485764..2486099	-	336	WP_165091991.1	chaperone NapD	-
SBC1_RS10870	2486160..2486318	-	159	WP_158934280.1	periplasmic nitrate reductase, NapE protein	-
SBC1_RS10875	2486745..2487449	-	705	WP_165091992.1	glutathione S-transferase N-terminal domain-containing protein	-
SBC1_RS10880	2487736..2489913	+	2178	WP_165091993.1	malate synthase G	-
SBC1_RS10885	2489976..2490209	+	234	WP_165093262.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
SBC1_RS10890	2490196..2490612	+	417	WP_165093264.1	PIN domain-containing protein	Toxin
SBC1_RS10900	2490997..2493015	-	2019	WP_165987611.1	cation acetate symporter	-
SBC1_RS10905	2493023..2493370	-	348	WP_165091995.1	DUF4212 domain-containing protein	-
SBC1_RS10910	2493509..2495491	-	1983	WP_165091996.1	acetate--CoA ligase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (6-116)

Antitoxin

• SpoVT-AbrB domain (5-37)

Sequences

Toxin

Protein

• Length: 139 a.a.
• Molecular weight: 15033.25 Da
• Isoelectric Point: 4.4937

>T150648 WP_165093264.1 NZ_CP049156:2490196-2490612 [Caballeronia sp. SBC1]
IAMAKVFLDSNVALYLLSGDAVKADRAEGLMAEGGVISVQVLNEIANVTRRKLAMSWRETNDVLDAVRAVCTTEPLTVET
HDTGRRISERYGLSVYDSMIVAAALLGGCDVLYSEDMHDGLVIEERLRIVNPFVSTGM

Nucleotide

• Length: 417 bp

>T150648 NZ_CP064855:1899554-1899733 [Erwinia amylovora]
ATGGATAGCAGGAATGCAATAGCAATGATAGAGGCCGATGGATGGTATCTGGTGAGAGTAAAAGGCAGTCATCACCAGTT
CAAGCACCCAACGAAAAAAGGGCTGGTAACGGTAAAACATCCCCAAAAGGACATACCGCTACCAACGCTGAAAAGCATTA
AAAAACAGGCGGGGCTTTAA

Antitoxin

Protein

• Length: 78 a.a.
• Molecular weight: 8632.81 Da
• Isoelectric Point: 8.6823

>AT150648 WP_165093262.1 NZ_CP049156:2489976-2490209 [Caballeronia sp. SBC1]
MQVSKWGNSLAIRLPAAVVEALELHEGDDVEVVIAGAREFQIKKKPAGRALLDRLRQYRGRLPADFTFNRDDANRDG

Nucleotide

• Length: 234 bp

>AT150648 NZ_CP064855:1899756-1900166 [Erwinia amylovora]
ATGTTATACCCTGTTGCTATTGATAAAGGCGATTCATCCTTCGGCGTTCGCGTACCCGATATTCCAGGCTGCTTCTCTGG
CGGCGACAATTATCAGGATGCGATTGAGAGCGCGCGTGAGGCTATCGACGCGCATATCGAATTACTGGTGGAAGATGGCG
AAGCGGTGCCGGAAGCGACCAGCGTGGAAAACTGGCTGGCCGATCCCGATTATGTTGGTGTGGTGTGGGCGCTGGTAGAT
GTGGACGTTACCCGGCTGATGGGGAAAGCGGAAAAAATCAATGTTACGCTCCCTTCTTTACTGATCCGCCGTATCGATCA
GTTTGTCGCTGCACATCCTGAGTACGGTAGCCGTTCCGGCTTCCTGTCCCGCGTGGCGGCTGATAAAGTGATTGGTCGCG
AAAAACGTTAA