Detailed information of TA system TA150646

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/upstrm_HI1419-dnstrm_HI1420
• Location: 1319163..1319761
• Replicon: chromosome
• Accession: NZ_CP049156
• Organism: Caballeronia sp. SBC1

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: SBC1_RS05720
• Protein ID: WP_165088423.1
• Coordinates: 1319453..1319761 (-)
• Length: 103 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: SBC1_RS05715
• Protein ID: WP_165088420.1
• Coordinates: 1319163..1319456 (-)
• Length: 98 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SBC1_RS05700	1315255..1316400	+	1146	WP_165088410.1	PAS domain-containing sensor histidine kinase	-
SBC1_RS05705	1316545..1318050	+	1506	WP_165088414.1	nitrogen regulation protein NR(I)	-
SBC1_RS05710	1318227..1319003	-	777	WP_165088417.1	exodeoxyribonuclease III	-
SBC1_RS05715	1319163..1319456	-	294	WP_165088420.1	putative addiction module antidote protein	Antitoxin
SBC1_RS05720	1319453..1319761	-	309	WP_165088423.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
SBC1_RS05725	1320058..1321332	+	1275	WP_165088428.1	amidohydrolase family protein	-
SBC1_RS05730	1321473..1322090	-	618	WP_165088431.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Addiction module killer protein, predicted (4-96)

Antitoxin

• Cro/C1-type helix-turn-helix domain (39-90)

Sequences

Toxin

Protein

• Length: 103 a.a.
• Molecular weight: 11480.23 Da
• Isoelectric Point: 10.6682

>T150646 WP_165088423.1 NZ_CP049156:c1319761-1319453 [Caballeronia sp. SBC1]
MTNTINQTHDFSVWLLGVTDVLARAAILIRIKRAALGNFGDCHDVGSSVWEMRIHTGAGYRVYYVRDGSTVYLLLAGGSK
RGQISDIARAKAMWQRIRQERK

Nucleotide

• Length: 309 bp

>T150646 NZ_CP064855:c1084739-1084521 [Erwinia amylovora]
ATGACTGACAAACTTCTAACGAAAACTGACTACCTGATGCGCCTCAGGCGTTGTCGTTCAATCGATACACTTGAACGCGT
GATTGAAAAGAACAAGTACGAATTATCTGATGATGAACTGGCTGTATTTTATTCAGCCGCCGATCACCGTCTTGCTGAAC
TAACCATGAATAAGCTGTACGACAAAGTACCGGTCGCTGTCTGGAAGTTTGTCCGTTAA

Antitoxin

Protein

• Length: 98 a.a.
• Molecular weight: 10187.53 Da
• Isoelectric Point: 5.0484

>AT150646 WP_165088420.1 NZ_CP049156:c1319456-1319163 [Caballeronia sp. SBC1]
MNSTHISAFDASDYLDSEEAIAAYLNEALASGDSDILLSALADIVKARGMSKVASDAGVQRESLYKSLAEGAKPRFETIQ
KVAAALGVKLVAVPVHH

Nucleotide

• Length: 294 bp

>AT150646 NZ_CP064855:c1085148-1084759 [Erwinia amylovora]
ATGGACGAATACTCACCGAAAAGGCATGATATTGCGCAGCTGAAATTCTTATGTGAAAACCTGTATGATGAAAGTCTGGC
TACGTTAGGCGACAGCCATCATGGCTGGGTTAACGACCCCACCTCAACGAGCAATCTTCAGCTTAACGACCTGATAGAGC
ACATTGCAGCATTCACAATGAATTACAAAATCAAGCATATCGAAGACAGCGATCTGATAAGTCAAATTGATGAGTATCTG
GACGACACCTTTATGCTTTTCAGCAATTACGGTGTCAACAATCTTGACTTACAACGCTGGCAAAAATCAGCGAAGCGATT
GTTTAACATTTTTGCTAAAGAATGCGTAATGAGCCAGATCCAGTCCAGCCATTCATTTAGCAGCCCATAA